Detalhe da pesquisa
1.
An autosomal-dominant childhood-onset disorder associated with pathogenic variants in VCP.
Am J Hum Genet
; 110(11): 1959-1975, 2023 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37883978
2.
Targeted inhibition of gut bacterial ß-glucuronidase activity enhances anticancer drug efficacy.
Proc Natl Acad Sci U S A
; 117(13): 7374-7381, 2020 03 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32170007
3.
Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases.
Biochemistry
; 59(40): 3939-3950, 2020 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32993284
4.
Three structurally and functionally distinct ß-glucuronidases from the human gut microbe Bacteroides uniformis.
J Biol Chem
; 293(48): 18559-18573, 2018 11 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-30301767
5.
Neurodegenerative Disease Tauopathies.
Annu Rev Pathol
; 19: 345-370, 2024 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37832941
6.
Ultrastructure of human brain tissue vitrified from autopsy revealed by cryo-ET with cryo-plasma FIB milling.
Nat Commun
; 15(1): 2660, 2024 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38531877
7.
VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models.
J Clin Invest
; 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38787785
8.
Native ultrastructure of fresh human brain vitrified directly from autopsy revealed by cryo-electron tomography with cryo-plasma focused ion beam milling.
bioRxiv
; 2023 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37745569
9.
Novel VCP activator reverses multisystem proteinopathy nuclear proteostasis defects and enhances TDP-43 aggregate clearance.
bioRxiv
; 2023 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36993559
10.
The Cryo-EM Effect: Structural Biology of Neurodegenerative Disease Proteostasis Factors.
J Neuropathol Exp Neurol
; 80(6): 494-513, 2021 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33860329
11.
The Cryo-EM Effect: Structural Biology of Neurodegenerative Disease Aggregates.
J Neuropathol Exp Neurol
; 80(6): 514-529, 2021 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33970243
12.
Mouse Gut Microbiome-Encoded ß-Glucuronidases Identified Using Metagenome Analysis Guided by Protein Structure.
mSystems
; 4(4)2019 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31455640
13.
Discovery and Characterization of FMN-Binding ß-Glucuronidases in the Human Gut Microbiome.
J Mol Biol
; 431(5): 970-980, 2019 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30658055
14.
Gut Microbial ß-Glucuronidase Inhibition via Catalytic Cycle Interception.
ACS Cent Sci
; 4(7): 868-879, 2018 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30062115
15.
An Atlas of ß-Glucuronidases in the Human Intestinal Microbiome.
Structure
; 25(7): 967-977.e5, 2017 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28578872