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1.
Am J Transplant ; 21(1): 258-271, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-32812351

RESUMO

The net impact of cytomegalovirus (CMV) DNAemia on overall mortality (OM) and nonrelapse mortality (NRM) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a matter of debate. This was a retrospective, multicenter, noninterventional study finally including 749 patients. CMV DNA monitoring was conducted by real-time polymerase chain reaction (PCR) assays. Clinical outcomes of interest were OM and NRM through day 365 after allo-HSCT. The cumulative incidence of CMV DNAemia in this cohort was 52.6%. A total of 306 out of 382 patients with CMV DNAemia received preemptive antiviral therapy (PET). PET use for CMV DNAemia, but not the occurrence of CMV DNAemia, taken as a qualitative variable, was associated with increased OM and NRM in univariate but not in adjusted models. A subcohort analysis including patients monitored by the COBAS Ampliprep/COBAS Taqman CMV Test showed that OM and NRM were comparable in patients in whom either low or high plasma CMV DNA threshold (<500 vs ≥500 IU/mL) was used for PET initiation. In conclusion, CMV DNAemia was not associated with increased OM and NRM in allo-HSCT recipients. The potential impact of PET use on mortality was not proven but merits further research.


Assuntos
Infecções por Citomegalovirus , Transplante de Células-Tronco Hematopoéticas , Citomegalovirus/genética , DNA Viral/genética , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Humanos , Estudos Retrospectivos , Transplante Homólogo/efeitos adversos
2.
Dig Dis Sci ; 48(5): 898-905, 2003 May.
Artigo em Inglês | MEDLINE | ID: mdl-12772786

RESUMO

We studied the influence of the inflammatory state of the gallbladder with gallstones on its response to cholecystokinin (CCK). Responses to CCK were evaluated in isolated human gallbladder strips incubated with pharmacological antagonists. Gallbladders from patients with gallstones were classified as having mild and severe chronic cholecystitis. Healthy gallbladders were collected from liver donors. In donor gallbladders, the CCK contraction was abolished with the CCK-A receptor antagonist, L-364718, and significantly reduced by indomethacin. In gallbladders with gallstones, only mild cholecystitis showed a decreased contraction to CCK. In gallbladders with gallstones, no involvement of prostaglandins in the CCK response was observed. In severe cholecystitis, CCK contractile effect was reduced by the serotonin receptor antagonist methysergide. In healthy gallbladder, the contraction provoked by CCK is mediated by CCK-A receptors and modulated by prostaglandins. The presence of gallstones in the gallbladder is correlated with a loss of prostaglandins-modulated CCK contraction. However, the excessive release of serotonin in advanced cholecystitis normalizes the contraction to CCK, suggesting that the state of cholecystitis affects the pool of inflammatory mediators responsible for gallbladder CCK-altered motility.


Assuntos
Colecistite/patologia , Colecistocinina/farmacologia , Colelitíase/patologia , Contração Muscular/efeitos dos fármacos , Acetilcolina/farmacologia , Adulto , Atropina/farmacologia , Colecistectomia/métodos , Colecistite/etiologia , Colecistite/cirurgia , Colelitíase/complicações , Colelitíase/cirurgia , Interações Medicamentosas , Feminino , Esvaziamento da Vesícula Biliar/efeitos dos fármacos , Histamina/farmacologia , Humanos , Indometacina/farmacologia , Masculino , Pessoa de Meia-Idade , Técnicas de Cultura de Órgãos , Probabilidade , Propranolol/farmacologia , Sensibilidade e Especificidade , Serotonina/farmacologia , Índice de Gravidade de Doença , Tetrodotoxina/farmacologia
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