1.
Appl Biochem Biotechnol
; 83(1-3): 53-60; discussion 60-2, 145-53, 2000.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10826948
RESUMO
The physiological mechanism for producing antigen-specific antibodies is based on a two-phase neo-Darwinian process: the first phase consists of diversity generation (formation of the repertoire), and the second phase is antigen-mediated selection. In this article, we consider how the natural immunoglobulin gene-diversification processes can be exploited both in vivo and in vitro in order to allow the generation of novel antibody (and heterologous protein) repertoires.