Detalhe da pesquisa
1.
Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation.
J Am Chem Soc
; 146(7): 4582-4591, 2024 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38330910
2.
An Integrated Strategy for Assessing the Metabolic Stability and Biotransformation of Macrocyclic Peptides in Drug Discovery toward Oral Delivery.
Anal Chem
; 94(4): 2032-2041, 2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041378
3.
Inhibition of Escherichia coli Lipoprotein Diacylglyceryl Transferase Is Insensitive to Resistance Caused by Deletion of Braun's Lipoprotein.
J Bacteriol
; 203(13): e0014921, 2021 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33875545
4.
Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling.
Proc Natl Acad Sci U S A
; 110(28): 11379-84, 2013 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-23801757
5.
Hydrogel-Encapsulated Beads Enable Proximity-Driven Encoded Library Synthesis and Screening.
ACS Cent Sci
; 9(8): 1603-1610, 2023 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37637732
6.
Evaluating Translational Efficiency of Noncanonical Amino Acids to Inform the Design of Druglike Peptide Libraries.
ACS Chem Biol
; 18(1): 81-90, 2023 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36607609
7.
Liposomal Permeation Assay for Droplet-Scale Pharmacokinetic Screening.
J Med Chem
; 66(9): 6288-6296, 2023 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37075027
8.
Identification of Macrocyclic Peptide Families from Combinatorial Libraries Containing Noncanonical Amino Acids Using Cheminformatics and Bioinformatics Inspired Clustering.
ACS Chem Biol
; 18(6): 1425-1434, 2023 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37220419
9.
Computational Site Saturation Mutagenesis of Canonical and Non-Canonical Amino Acids to Probe Protein-Peptide Interactions.
Front Mol Biosci
; 9: 848689, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35495632
10.
Ribosomal Synthesis of Macrocyclic Peptides with Linear γ4- and ß-Hydroxy-γ4-amino Acids.
ACS Chem Biol
; 16(8): 1325-1331, 2021 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34270222
11.
Ribosomal Synthesis of Macrocyclic Peptides with ß2- and ß2,3-Homo-Amino Acids for the Development of Natural Product-Like Combinatorial Libraries.
ACS Chem Biol
; 16(6): 1011-1018, 2021 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34008946
12.
Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling.
Cell Rep
; 31(12): 107809, 2020 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32579935
13.
Targeting the Hippo Pathway and Cancer through the TEAD Family of Transcription Factors.
Cancers (Basel)
; 10(3)2018 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29558384
14.
Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin.
Structure
; 25(5): 739-749.e3, 2017 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28416112
15.
Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling.
Structure
; 24(1): 179-186, 2016 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26724994
16.
USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.
Nat Cell Biol
; 17(2): 160-9, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25621951
17.
Decoding a chain letter for degradation.
Structure
; 21(7): 1068-70, 2013 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23823323
18.
The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis.
Protein Sci
; 21(8): 1162-71, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22653663
19.
Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.
ACS Med Chem Lett
; 1(1): 4-8, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20730035
20.
Intra- and intermonomer interactions are required to synergistically facilitate ATP hydrolysis in Hsp90.
J Biol Chem
; 283(30): 21170-8, 2008 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-18492664