Detalhe da pesquisa
1.
Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry.
Bioorg Med Chem
; 42: 116223, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34091303
2.
Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology.
Proc Natl Acad Sci U S A
; 113(49): E7880-E7889, 2016 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27864515
3.
Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA-Encoded Chemical Library.
Chembiochem
; 18(9): 864-871, 2017 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28056160
4.
Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists.
Bioorg Med Chem
; 22(7): 2353-65, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24593905
5.
Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening.
ACS Infect Dis
; 10(5): 1561-1575, 2024 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38577994
6.
Development of Potent Mcl-1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen.
J Med Chem
; 67(4): 3039-3065, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38306405
7.
Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning.
J Med Chem
; 66(23): 16051-16061, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37996079
8.
Discovery of Nanomolar DCAF1 Small Molecule Ligands.
J Med Chem
; 66(7): 5041-5060, 2023 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36948210
9.
Corrigendum: Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNAEncoded Chemical Library.
Chembiochem
; 18(24): 2441, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29239533
10.
Design, synthesis and selection of DNA-encoded small-molecule libraries.
Nat Chem Biol
; 5(9): 647-54, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19648931
11.
Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening.
J Med Chem
; 64(10): 6730-6744, 2021 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33955740
12.
Discovery of 2,4-1H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors.
ACS Med Chem Lett
; 12(4): 555-562, 2021 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33859795
13.
Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening.
J Med Chem
; 64(8): 5049-5066, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33844532
14.
Discovery of Novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa.
J Med Chem
; 64(19): 14377-14425, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34569791
15.
Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry.
J Med Chem
; 63(14): 7840-7856, 2020 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32584034
16.
Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding.
J Med Chem
; 63(16): 8857-8866, 2020 08 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32525674
17.
Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target.
SLAS Discov
; 23(5): 429-436, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29316408
18.
Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.
J Med Chem
; 50(19): 4728-45, 2007 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-17715908
19.
Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.
ACS Med Chem Lett
; 8(2): 239-244, 2017 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28197319
20.
Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action.
ACS Chem Biol
; 12(11): 2730-2736, 2017 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29043777