Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

GPCRs in the round: SMA-like copolymers and SMALPs as a platform for investigating GPCRs.

Ayub, Hoor; Murray, Rebecca J; Kuyler, Gestél C; Napier-Khwaja, Farhaan; Gunner, Joseph; Dafforn, Tim R; Klumperman, Bert; Poyner, David R; Wheatley, Mark.

Arch Biochem Biophys ; 754: 109946, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38395122

2.

Purification and characterisation of the platelet-activating GPVI/FcRÎ³ complex in SMALPs.

Wang, Xueqing; Slater, Alexandre; Lee, Sarah C; Harrison, Neale; Pollock, Naomi L; Bakker, Saskia E; Navarro, Stefano; Nieswandt, Bernhard; Dafforn, Tim R; García, Ángel; Watson, Steve P; Tomlinson, Michael G.

Arch Biochem Biophys ; 754: 109944, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38395124

3.

Biophysical characterisation of SMALPs.

Nestorow, Stephanie A; Dafforn, Tim R; Frasca, Verna.

Biochem Soc Trans ; 49(5): 2037-2050, 2021 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-34643233

4.

Pandemic research: UK must coordinate.

Dafforn, Tim R.

Nature ; 582(7811): 184, 2020 06.

Artigo em Inglês | MEDLINE | ID: mdl-32488186

5.

Automated High-Throughput Capillary Circular Dichroism and Intrinsic Fluorescence Spectroscopy for Rapid Determination of Protein Structure.

Moore-Kelly, Charles; Welsh, John; Rodger, Alison; Dafforn, Tim R; Thomas, Owen R T.

Anal Chem ; 91(21): 13794-13802, 2019 11 05.

Artigo em Inglês | MEDLINE | ID: mdl-31584804

6.

Purification of membrane proteins free from conventional detergents: SMA, new polymers, new opportunities and new insights.

Stroud, Zoe; Hall, Stephen C L; Dafforn, Tim R.

Methods ; 147: 106-117, 2018 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-29608964

7.

Influence of Poly(styrene- co-maleic acid) Copolymer Structure on the Properties and Self-Assembly of SMALP Nanodiscs.

Hall, Stephen C L; Tognoloni, Cecilia; Price, Gareth J; Klumperman, Bert; Edler, Karen J; Dafforn, Tim R; Arnold, Thomas.

Biomacromolecules ; 19(3): 761-772, 2018 03 12.

Artigo em Inglês | MEDLINE | ID: mdl-29272585

8.

Membrane protein insertion and assembly by the bacterial holo-translocon SecYEG-SecDF-YajC-YidC.

Komar, Joanna; Alvira, Sara; Schulze, Ryan J; Martin, Remy; Lycklama A Nijeholt, Jelger A; Lee, Sarah C; Dafforn, Tim R; Deckers-Hebestreit, Gabriele; Berger, Imre; Schaffitzel, Christiane; Collinson, Ian.

Biochem J ; 473(19): 3341-54, 2016 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-27435098

9.

The use of SMALPs as a novel membrane protein scaffold for structure study by negative stain electron microscopy.

Postis, Vincent; Rawson, Shaun; Mitchell, Jennifer K; Lee, Sarah C; Parslow, Rosemary A; Dafforn, Tim R; Baldwin, Stephen A; Muench, Stephen P.

Biochim Biophys Acta ; 1848(2): 496-501, 2015 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-25450810

10.

GPCR-styrene maleic acid lipid particles (GPCR-SMALPs): their nature and potential.

Wheatley, Mark; Charlton, Jack; Jamshad, Mohammed; Routledge, Sarah J; Bailey, Sian; La-Borde, Penelope J; Azam, Maria T; Logan, Richard T; Bill, Roslyn M; Dafforn, Tim R; Poyner, David R.

Biochem Soc Trans ; 44(2): 619-23, 2016 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-27068979

11.

The interaction of styrene maleic acid copolymers with phospholipids in Langmuir monolayers, vesicles and nanodiscs; a structural study.

Hall, Stephen C L; Tognoloni, Cecilia; Campbell, Richard A; Richens, Joanna; O'Shea, Paul; Terry, Ann E; Price, Gareth J; Dafforn, Tim R; Edler, Karen J; Arnold, Thomas.

J Colloid Interface Sci ; 625: 220-236, 2022 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-35716617

12.

Surfactant-free purification of membrane proteins with intact native membrane environment.

Jamshad, Mohammed; Lin, Yu-Pin; Knowles, Timothy J; Parslow, Rosemary A; Harris, Craig; Wheatley, Mark; Poyner, David R; Bill, Roslyn M; Thomas, Owen R T; Overduin, Michael; Dafforn, Tim R.

Biochem Soc Trans ; 39(3): 813-8, 2011 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-21599653

13.

Differences in SMA-like polymer architecture dictate the conformational changes exhibited by the membrane protein rhodopsin encapsulated in lipid nano-particles.

Grime, Rachael L; Logan, Richard T; Nestorow, Stephanie A; Sridhar, Pooja; Edwards, Patricia C; Tate, Christopher G; Klumperman, Bert; Dafforn, Tim R; Poyner, David R; Reeves, Philip J; Wheatley, Mark.

Nanoscale ; 13(31): 13519-13528, 2021 Aug 21.

Artigo em Inglês | MEDLINE | ID: mdl-34477756

14.

Releasing the technical 'shackles' on GPCR drug discovery: opportunities enabled by detergent-free polymer lipid particle (PoLiPa) purification.

Hothersall, J Daniel; Jones, Andrew Y; Dafforn, Tim R; Perrior, Trevor; Chapman, Kathryn L.

Drug Discov Today ; 2020 Aug 21.

Artigo em Inglês | MEDLINE | ID: mdl-32835806

15.

Insights on the Quest for the Structure-Function Relationship of the Mitochondrial Pyruvate Carrier.

Quesñay, José Edwin Neciosup; Pollock, Naomi L; Nagampalli, Raghavendra Sashi Krishna; Lee, Sarah C; Balakrishnan, Vijayakumar; Dias, Sandra Martha Gomes; Moraes, Isabel; Dafforn, Tim R; Ambrosio, Andre Luis Berteli.

Biology (Basel) ; 9(11)2020 Nov 19.

Artigo em Inglês | MEDLINE | ID: mdl-33227948

16.

Ligand-induced conformational changes in a SMALP-encapsulated GPCR.

Routledge, Sarah J; Jamshad, Mohammed; Little, Haydn A; Lin, Yu-Pin; Simms, John; Thakker, Alpesh; Spickett, Corinne M; Bill, Roslyn M; Dafforn, Tim R; Poyner, David R; Wheatley, Mark.

Biochim Biophys Acta Biomembr ; 1862(6): 183235, 2020 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-32126232

17.

Adsorption of a styrene maleic acid (SMA) copolymer-stabilized phospholipid nanodisc on a solid-supported planar lipid bilayer.

Hall, Stephen C L; Clifton, Luke A; Tognoloni, Cecilia; Morrison, Kerrie A; Knowles, Timothy J; Kinane, Christian J; Dafforn, Tim R; Edler, Karen J; Arnold, Thomas.

J Colloid Interface Sci ; 574: 272-284, 2020 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-32330753

18.

Peptide adsorption to lipid bilayers: slow processes revealed by linear dichroism spectroscopy.

Ennaceur, Sue M; Hicks, Matthew R; Pridmore, Catherine J; Dafforn, Tim R; Rodger, Alison; Sanderson, John M.

Biophys J ; 96(4): 1399-407, 2009 Feb 18.

Artigo em Inglês | MEDLINE | ID: mdl-19217857

19.

SMA-PAGE: A new method to examine complexes of membrane proteins using SMALP nano-encapsulation and native gel electrophoresis.

Pollock, Naomi L; Rai, Megha; Simon, Kailene S; Hesketh, Sophie J; Teo, Alvin C K; Parmar, Mayuriben; Sridhar, Pooja; Collins, Richard; Lee, Sarah C; Stroud, Zoe N; Bakker, Saskia E; Muench, Stephen P; Barton, C Howard; Hurlbut, Gregory; Roper, David I; Smith, Corinne J I; Knowles, Timothy J; Spickett, Corinne M; East, J Malcolm; Postis, Vincent L G; Dafforn, Tim R.

Biochim Biophys Acta Biomembr ; 1861(8): 1437-1445, 2019 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-31150633

20.

Functional domains of the human epididymal protease inhibitor, eppin.

McCrudden, Maelíosa T C; Dafforn, Tim R; Houston, David F; Turkington, Philip T; Timson, David J.

FEBS J ; 275(8): 1742-50, 2008 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-18331357

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