Detalhe da pesquisa
1.
A class of highly selective inhibitors bind to an active state of PI3Kγ.
Nat Chem Biol
; 15(4): 348-357, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30718815
2.
Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments.
J Am Chem Soc
; 142(10): 4904-4915, 2020 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32058716
3.
Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
J Biol Chem
; 293(15): 5492-5508, 2018 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29414779
4.
Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization.
J Med Chem
; 66(19): 13400-13415, 2023 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37738648
5.
Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma.
Drug Des Devel Ther
; 16: 2901-2917, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36068788
6.
Mechanistic and kinetic characterization of hepatitis C virus NS3 protein interactions with NS4A and protease inhibitors.
J Mol Recognit
; 24(1): 60-70, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21194118
7.
The Vital Role of Proteomics in Characterizing Novel Protein Degraders.
SLAS Discov
; 26(4): 518-523, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33615886
8.
Regenerable Biosensors for Small-Molecule Kinetic Characterization Using SPR.
SLAS Discov
; 26(5): 730-739, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33289457
9.
Proteolysis-targeting chimeras in drug development: A safety perspective.
Br J Pharmacol
; 177(8): 1709-1718, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32022252
10.
Hepatitis C virus NS3 protease is activated by low concentrations of protease inhibitors.
Biochemistry
; 48(48): 11592-602, 2009 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19839643
11.
Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain.
Sci Adv
; 5(7): eaau4202, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31392261
12.
Beta-amino acid substitutions and structure-based CoMFA modeling of hepatitis C virus NS3 protease inhibitors.
Bioorg Med Chem
; 16(10): 5590-605, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18434166
13.
A Comparative Study of Fluorescence Assays in Screening for BRD4.
Assay Drug Dev Technol
; 16(7): 372-383, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30307314
14.
Inhibition of low-density lipoprotein receptor degradation with a cyclic peptide that disrupts the homodimerization of IDOL E3 ubiquitin ligase.
Chem Sci
; 9(27): 5957-5966, 2018 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30079210
15.
Resistance profiling of hepatitis C virus protease inhibitors using full-length NS3.
Antivir Ther
; 12(5): 733-40, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17713156
16.
Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3.
FEBS J
; 274(22): 5979-86, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17949436
17.
Unified Software Solution for Efficient SPR Data Analysis in Drug Research.
SLAS Discov
; 22(2): 203-209, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27789754
18.
A comprehensive company database analysis of biological assay variability.
Drug Discov Today
; 21(8): 1213-21, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27063506
19.
Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986).
J Med Chem
; 59(20): 9457-9472, 2016 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27690432
20.
Pharmacokinetics and the drug-target residence time concept.
Drug Discov Today
; 18(15-16): 697-707, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23500610