Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

In Vivo Photoadduction of Anesthetic Ligands in Mouse Brain Markedly Extends Sedation and Hypnosis.

McKinstry-Wu, Andrew R; Wasilczuk, Andrzej Z; Dailey, William P; Eckenhoff, Roderic G; Kelz, Max B.

J Neurosci ; 43(13): 2338-2348, 2023 03 29.

Artigo em Inglês | MEDLINE | ID: mdl-36849414

2.

Regulation and drug modulation of a voltage-gated sodium channel: Pivotal role of the S4-S5 linker in activation and slow inactivation.

Xiao, Jinglei; Bondarenko, Vasyl; Wang, Yali; Suma, Antonio; Wells, Marta; Chen, Qiang; Tillman, Tommy; Luo, Yan; Yu, Buwei; Dailey, William P; Eckenhoff, Roderic; Tang, Pei; Carnevale, Vincenzo; Klein, Michael L; Xu, Yan.

Proc Natl Acad Sci U S A ; 118(28)2021 07 13.

Artigo em Inglês | MEDLINE | ID: mdl-34260401

3.

An allosteric propofol-binding site in kinesin disrupts kinesin-mediated processive movement on microtubules.

Woll, Kellie A; Guzik-Lendrum, Stephanie; Bensel, Brandon M; Bhanu, Natarajan V; Dailey, William P; Garcia, Benjamin A; Gilbert, Susan P; Eckenhoff, Roderic G.

J Biol Chem ; 293(29): 11283-11295, 2018 07 20.

Artigo em Inglês | MEDLINE | ID: mdl-29844014

4.

A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of Î³-Aminobutyric Acid, Type A (GABAA), Receptor Subunit Binding Selectivity in Synaptosomes.

Woll, Kellie A; Murlidaran, Sruthi; Pinch, Benika J; Hénin, Jérôme; Wang, Xiaoshi; Salari, Reza; Covarrubias, Manuel; Dailey, William P; Brannigan, Grace; Garcia, Benjamin A; Eckenhoff, Roderic G.

J Biol Chem ; 291(39): 20473-86, 2016 09 23.

Artigo em Inglês | MEDLINE | ID: mdl-27462076

5.

Shedding Light on Anesthetic Mechanisms: Application of Photoaffinity Ligands.

Woll, Kellie A; Dailey, William P; Brannigan, Grace; Eckenhoff, Roderic G.

Anesth Analg ; 123(5): 1253-1262, 2016 11.

Artigo em Inglês | MEDLINE | ID: mdl-27464974

6.

Multiple propofol-binding sites in a Î³-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.

Jayakar, Selwyn S; Zhou, Xiaojuan; Chiara, David C; Dostalova, Zuzana; Savechenkov, Pavel Y; Bruzik, Karol S; Dailey, William P; Miller, Keith W; Eckenhoff, Roderic G; Cohen, Jonathan B.

J Biol Chem ; 289(40): 27456-68, 2014 Oct 03.

Artigo em Inglês | MEDLINE | ID: mdl-25086038

7.

Photoaffinity labeling the propofol binding site in GLIC.

Chiara, David C; Gill, Jonathan F; Chen, Qiang; Tillman, Tommy; Dailey, William P; Eckenhoff, Roderic G; Xu, Yan; Tang, Pei; Cohen, Jonathan B.

Biochemistry ; 53(1): 135-42, 2014 Jan 14.

Artigo em Inglês | MEDLINE | ID: mdl-24341978

8.

Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog.

Jayakar, Selwyn S; Dailey, William P; Eckenhoff, Roderic G; Cohen, Jonathan B.

J Biol Chem ; 288(9): 6178-89, 2013 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-23300078

9.

Synthesis and Characterization of a Diazirine-Based Photolabel of the Nonanesthetic Fropofol.

White, E Railey; Leace, David M; Bedell, Victoria M; Bhanu, Natarajan V; Garcia, Benjamin A; Dailey, William P; Eckenhoff, Roderic G.

ACS Chem Neurosci ; 12(1): 176-183, 2021 01 06.

Artigo em Inglês | MEDLINE | ID: mdl-33355437

10.

Fropofol prevents disease progression in mice with hypertrophic cardiomyopathy.

Huang, Yiyuan; Lu, Haisong; Ren, Xianfeng; Li, Fazhao; Bu, Weiming; Liu, Wenjie; Dailey, William P; Saeki, Harumi; Gabrielson, Kathleen; Abraham, Roselle; Eckenhoff, Roderic; Gao, Wei Dong.

Cardiovasc Res ; 116(6): 1175-1185, 2020 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-31424496

11.

Azi-medetomidine: Synthesis and Characterization of a Novel α2 Adrenergic Photoaffinity Ligand.

McKinstry-Wu, Andrew R; Woll, Kellie A; Joseph, Thomas T; Bu, Weiming; White, E Railey; Bhanu, Natarajan V; Garcia, Benjamin A; Brannigan, Grace; Dailey, William P; Eckenhoff, Roderic G.

ACS Chem Neurosci ; 10(11): 4716-4728, 2019 11 20.

Artigo em Inglês | MEDLINE | ID: mdl-31638765

12.

Identification of General Anesthetic Target Protein-Binding Sites by Photoaffinity Labeling and Mass Spectrometry.

Woll, Kellie A; Dailey, William P; Eckenhoff, Roderic G.

Methods Enzymol ; 602: 231-246, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-29588031

13.

Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites.

Wang, Yali; Yang, Elaine; Wells, Marta M; Bondarenko, Vasyl; Woll, Kellie; Carnevale, Vincenzo; Granata, Daniele; Klein, Michael L; Eckenhoff, Roderic G; Dailey, William P; Covarrubias, Manuel; Tang, Pei; Xu, Yan.

J Gen Physiol ; 150(9): 1317-1331, 2018 09 03.

Artigo em Inglês | MEDLINE | ID: mdl-30018039

14.

Photoaffinity Ligand for the Inhalational Anesthetic Sevoflurane Allows Mechanistic Insight into Potassium Channel Modulation.

Woll, Kellie A; Peng, Wesley; Liang, Qiansheng; Zhi, Lianteng; Jacobs, Jack A; Maciunas, Lina; Bhanu, Natarajan; Garcia, Benjamin A; Covarrubias, Manuel; Loll, Patrick J; Dailey, William P; Eckenhoff, Roderic G.

ACS Chem Biol ; 12(5): 1353-1362, 2017 05 19.

Artigo em Inglês | MEDLINE | ID: mdl-28333442

15.

Macroscopic and macromolecular specificity of alkylphenol anesthetics for neuronal substrates.

Weiser, Brian P; Hall, Michael A; Weinbren, Nathan L; Woll, Kellie A; Dailey, William P; Eckenhoff, Maryellen F; Eckenhoff, Roderic G.

Sci Rep ; 5: 9695, 2015 Apr 08.

Artigo em Inglês | MEDLINE | ID: mdl-25853337

16.

Role for the propofol hydroxyl in anesthetic protein target molecular recognition.

Woll, Kellie A; Weiser, Brian P; Liang, Qiansheng; Meng, Tao; McKinstry-Wu, Andrew; Pinch, Benika; Dailey, William P; Gao, Wei Dong; Covarrubias, Manuel; Eckenhoff, Roderic G.

ACS Chem Neurosci ; 6(6): 927-35, 2015 Jun 17.

Artigo em Inglês | MEDLINE | ID: mdl-25799399

17.

Halogenated diazirines as photolabel mimics of the inhaled haloalkane anesthetics.

Eckenhoff, Roderic G; Knoll, Frank J; Greenblatt, Eric P; Dailey, William P.

J Med Chem ; 45(9): 1879-86, 2002 Apr 25.

Artigo em Inglês | MEDLINE | ID: mdl-11960499

18.

Mechanisms revealed through general anesthetic photolabeling.

Weiser, Brian P; Woll, Kellie A; Dailey, William P; Eckenhoff, Roderic G.

Curr Anesthesiol Rep ; 4(1): 57-66, 2014 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-24563623

19.

Fluorinated Carbenes.

Brahms, Dana Lyn S.; Dailey, William P..

Chem Rev ; 96(5): 1585-1632, 1996 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-11848805

20.

Inhalational anesthetic photolabeling.

Eckenhoff, Roderic G; Xi, Jin; Dailey, William P.

Methods Mol Biol ; 617: 437-43, 2010.

Artigo em Inglês | MEDLINE | ID: mdl-20336439

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