Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing.

Gavin, Amanda L; Huang, Deli; Huber, Christoph; Mårtensson, Annica; Tardif, Virginie; Skog, Patrick D; Blane, Tanya R; Thinnes, Therese C; Osborn, Kent; Chong, Hayley S; Kargaran, Farnaz; Kimm, Phoebe; Zeitjian, Armen; Sielski, Rachel L; Briggs, Megan; Schulz, Sebastian R; Zarpellon, Alessandro; Cravatt, Benjamin; Pang, Ee Shan; Teijaro, John; de la Torre, Juan Carlos; O'Keeffe, Meredith; Hochrein, Hubertus; Damme, Markus; Teyton, Luc; Lawson, Brian R; Nemazee, David.

Nat Immunol ; 19(9): 942-953, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-30111894

2.

Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation.

Roske, Yvette; Cappel, Cedric; Cremer, Nils; Hoffmann, Patrick; Koudelka, Tomas; Tholey, Andreas; Heinemann, Udo; Daumke, Oliver; Damme, Markus.

Nucleic Acids Res ; 52(1): 370-384, 2024 Jan 11.

Artigo em Inglês | MEDLINE | ID: mdl-37994783

3.

Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis.

Gallwitz, Lisa; Bleibaum, Florian; Voss, Matthias; Schweizer, Michaela; Spengler, Katharina; Winter, Dominic; Zöphel, Frederic; Müller, Stephan; Lichtenthaler, Stefan; Damme, Markus; Saftig, Paul.

Cell Mol Life Sci ; 81(1): 227, 2024 May 22.

Artigo em Inglês | MEDLINE | ID: mdl-38775843

4.

Multi-Cell Line Analysis of Lysosomal Proteomes Reveals Unique Features and Novel Lysosomal Proteins.

Akter, Fatema; Bonini, Sara; Ponnaiyan, Srigayatri; Kögler-Mohrbacher, Bianca; Bleibaum, Florian; Damme, Markus; Renard, Bernhard Y; Winter, Dominic.

Mol Cell Proteomics ; 22(3): 100509, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36791992

5.

S-palmitoylation determines TMEM55B-dependent positioning of lysosomes.

Rudnik, Sönke; Heybrock, Saskia; Saftig, Paul; Damme, Markus.

J Cell Sci ; 135(5)2022 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-34350967

6.

LAMP3 deficiency affects surfactant homeostasis in mice.

Lunding, Lars P; Krause, Daniel; Stichtenoth, Guido; Stamme, Cordula; Lauterbach, Niklas; Hegermann, Jan; Ochs, Matthias; Schuster, Björn; Sedlacek, Radislav; Saftig, Paul; Schwudke, Dominik; Wegmann, Michael; Damme, Markus.

PLoS Genet ; 17(6): e1009619, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-34161347

7.

Anchorless risk or released benefit? An updated view on the ADAM10-mediated shedding of the prion protein.

Mohammadi, Behnam; Song, Feizhi; Matamoros-Angles, Andreu; Shafiq, Mohsin; Damme, Markus; Puig, Berta; Glatzel, Markus; Altmeppen, Hermann Clemens.

Cell Tissue Res ; 392(1): 215-234, 2023 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-35084572

8.

Quantification and characterization of the 5' exonuclease activity of the lysosomal nuclease PLD3 by a novel cell-based assay.

Cappel, Cedric; Gonzalez, Adriana Carolina; Damme, Markus.

J Biol Chem ; 296: 100152, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33288674

9.

Usher syndrome type IV: clinically and molecularly confirmed by novel ARSG variants.

Velde, Hedwig M; Reurink, Janine; Held, Sebastian; Li, Catherina H Z; Yzer, Suzanne; Oostrik, Jaap; Weeda, Jack; Haer-Wigman, Lonneke; Yntema, Helger G; Roosing, Susanne; Pauleikhoff, Laurenz; Lange, Clemens; Whelan, Laura; Dockery, Adrian; Zhu, Julia; Keegan, David J; Farrar, G Jane; Kremer, Hannie; Lanting, Cornelis P; Damme, Markus; Pennings, Ronald J E.

Hum Genet ; 141(11): 1723-1738, 2022 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-35226187

10.

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.

Werner, Georg; Damme, Markus; Schludi, Martin; Gnörich, Johannes; Wind, Karin; Fellerer, Katrin; Wefers, Benedikt; Wurst, Wolfgang; Edbauer, Dieter; Brendel, Matthias; Haass, Christian; Capell, Anja.

EMBO Rep ; 21(10): e50241, 2020 10 05.

Artigo em Inglês | MEDLINE | ID: mdl-32929860

11.

Decoding the consecutive lysosomal degradation of 3-O-sulfate containing heparan sulfate by Arylsulfatase G (ARSG).

Kowalewski, Björn; Lange, Heike; Galle, Sabrina; Dierks, Thomas; Lübke, Torben; Damme, Markus.

Biochem J ; 478(17): 3221-3237, 2021 09 17.

Artigo em Inglês | MEDLINE | ID: mdl-34405855

12.

Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks.

Reinicke, Anna T; Laban, Karoline; Sachs, Marlies; Kraus, Vanessa; Walden, Michael; Damme, Markus; Sachs, Wiebke; Reichelt, Julia; Schweizer, Michaela; Janiesch, Philipp Christoph; Duncan, Kent E; Saftig, Paul; Rinschen, Markus M; Morellini, Fabio; Meyer-Schwesinger, Catherine.

Proc Natl Acad Sci U S A ; 116(16): 7963-7972, 2019 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-30923110

13.

CLN6 deficiency causes selective changes in the lysosomal protein composition.

Tuermer, Andreas; Mausbach, Simone; Kaade, Edgar; Damme, Markus; Sylvester, Marc; Gieselmann, Volkmar; Thelen, Melanie.

Proteomics ; 21(19): e2100043, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34432360

14.

New clinical and molecular evidence linking mutations in ARSG to Usher syndrome type IV.

Peter, Virginie G; Quinodoz, Mathieu; Sadio, Silvia; Held, Sebastian; Rodrigues, Márcia; Soares, Marta; Sousa, Ana Berta; Coutinho Santos, Luisa; Damme, Markus; Rivolta, Carlo.

Hum Mutat ; 42(3): 261-271, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33300174

15.

Characterization of the complex of the lysosomal membrane transporter MFSD1 and its accessory subunit GLMP.

López, David Massa; Kählau, Lea; Jungnickel, Katharina Esther Julia; Löw, Christian; Damme, Markus.

FASEB J ; 34(11): 14695-14709, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32959924

16.

Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice.

Moreau, Dimitri; Vacca, Fabrizio; Vossio, Stefania; Scott, Cameron; Colaco, Alexandria; Paz Montoya, Jonathan; Ferguson, Charles; Damme, Markus; Moniatte, Marc; Parton, Robert G; Platt, Frances M; Gruenberg, Jean.

EMBO Rep ; 20(7): e47055, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-31267706

17.

Lysosomal sulfatases: a growing family.

Lübke, Torben; Damme, Markus.

Biochem J ; 477(20): 3963-3983, 2020 10 30.

Artigo em Inglês | MEDLINE | ID: mdl-33120425

18.

Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome.

De Pace, Raffaella; Skirzewski, Miguel; Damme, Markus; Mattera, Rafael; Mercurio, Jeffrey; Foster, Arianne M; Cuitino, Loreto; Jarnik, Michal; Hoffmann, Victoria; Morris, H Douglas; Han, Tae-Un; Mancini, Grazia M S; Buonanno, Andrés; Bonifacino, Juan S.

PLoS Genet ; 14(4): e1007363, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29698489

19.

A mouse model for SPG48 reveals a block of autophagic flux upon disruption of adaptor protein complex five.

Khundadze, Mukhran; Ribaudo, Federico; Hussain, Adeela; Rosentreter, Jan; Nietzsche, Sandor; Thelen, Melanie; Winter, Dominic; Hoffmann, Birgit; Afzal, Muhammad Awais; Hermann, Tanja; de Heus, Cecilia; Piskor, Eva-Maria; Kosan, Christian; Franzka, Patricia; von Kleist, Lisa; Stauber, Tobias; Klumperman, Judith; Damme, Markus; Proikas-Cezanne, Tassula; Hübner, Christian A.

Neurobiol Dis ; 127: 419-431, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-30930081

20.

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.

Beel, Sander; Moisse, Matthieu; Damme, Markus; De Muynck, Louis; Robberecht, Wim; Van Den Bosch, Ludo; Saftig, Paul; Van Damme, Philip.

Hum Mol Genet ; 26(15): 2850-2863, 2017 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-28453791

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