RESUMO
Serum cholesterol and triglyceride concentrations in 34 normal women were monitored before, during and after pregnancy. All women displayed an initial fall in both substances during the first trimester. The concentrations increased to maximum values during the third trimester. There was a considerable variation in the time required for this hyperlipidaemia to decline after delivery. Lactation appeared to be an important factor in this variation; women who bottle-fed their infants maintained an elevated serum triglyceride level for three times longer than those who breast-fed their infants.
Assuntos
Colesterol/sangue , Gravidez , Triglicerídeos/sangue , Adulto , Feminino , Humanos , Lactação , Período Pós-PartoRESUMO
A 7-year-old girl presented with an extragonadal dysgerminoma arising from the pelvis. Her mother had been treated for a histologically identical pituitary tumor 3 years previously. The child's serum lactate dehydrogenase (LDH) level was markedly elevated at presentation and fell as the tumor responded to treatment. The potential use of LDH as a marker for gonadal dysgerminoma is well documented, but raised LDH in association with primary extragonadal dysgerminoma has not been described previously. In addition, this is the first report of extragonadal dysgerminoma occurring in female relatives.
Assuntos
Biomarcadores Tumorais/sangue , Disgerminoma/genética , L-Lactato Desidrogenase/sangue , Neoplasias Pélvicas/genética , Criança , Disgerminoma/diagnóstico , Feminino , Humanos , Neoplasias Pélvicas/diagnósticoRESUMO
A girl with acute lymphoblastic leukemia in remission had two seizures during the maintenance phase of her treatment. Magnetic resonance imaging with angiography identified a superior sagittal sinus thrombosis as the likely explanation for her symptoms. Possible causes are considered, and previous reports of the neurotoxicity of agents used in the treatment of leukemia are reviewed.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Embolia e Trombose Intracraniana/diagnóstico , Metotrexato/efeitos adversos , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Adulto , Ataxia , Neoplasias do Sistema Nervoso Central/prevenção & controle , Feminino , Humanos , Injeções Espinhais , Embolia e Trombose Intracraniana/induzido quimicamente , Angiografia por Ressonância Magnética , Metotrexato/administração & dosagem , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico , Prednisolona/administração & dosagem , Convulsões , Vincristina/administração & dosagemRESUMO
The presence or absence of a double pre-beta lipoprotein (pre-beta 1+ or pre-beta 1-) peak on agarose gel electrophoresis was recorded in: a) 77 survivors of myocardial infarction, b) their first-degree relatives, and c) 148 controls. Thirty-nine percent of myocardial infarction survivors and 24% of controls had pre-beta 1+ (P less than 0.05). The segregation of pre-beta 1+ in the families of myocardial infarction survivors was consistent with autosomal dominant inheritance. In the control group, fasting serum cholesterol and triglyceride values were higher in the pre beta 1+ subjects, but the differences were not significant. We conclude that the presence of double pre-beta lipoprotein peak on electrophoresis is associated with an increased risk of myocardial infarction.
Assuntos
Lipoproteínas VLDL/sangue , Infarto do Miocárdio/sangue , Colesterol/sangue , Inglaterra , Humanos , Infarto do Miocárdio/genética , Fenótipo , Risco , Triglicerídeos/sangueRESUMO
A longitudinal prospective study of serum cholesterol concentrations during the first year of life has been carried out in 302 healthy babies. The results show that serum cholesterol estimations in cord blood cannot be used as a screening test for the diagnosis of familial hypercholesterolaemia. The only child subsequently found to have the condition had a cord serum cholesterol of 85 mg/100 ml compared with the mean value for the group of 78 mg/100 ml. The babies who had cord values greater than 100 mg/100 ml had values distributed throughout the normal range when re-examined at 1 year of age. Serum cholesterol concentrations during the early months of life were markedly influenced by the type of milk fed; it is suggested that investigations to establish the diagnosis of familial hypercholesterolaemia are deferred until the child is about 1 year old and feeding with cows' milk and mixed diet is established.Values obtained for serum cholesterol concentrations (mg/100 ml, mean +/- 1 S.D.) in healthy infants in this study were: at birth 78 +/- 23, at 1 week 155 +/- 31, at 6 weeks 155 +/- 31, at 4 months 184 +/- 36, at 8 months 195 +/- 37, and at 1 year 191 +/- 36.
Assuntos
Colesterol/sangue , Adolescente , Adulto , Fatores Etários , Animais , Criança , Pré-Escolar , Dieta , Feminino , Humanos , Hiperlipidemias/diagnóstico , Hiperlipidemias/genética , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Leite , Estudos Prospectivos , Cordão UmbilicalRESUMO
Plasma 25-OHD levels were measured in the same 26 Caucasian women before pregnancy and during the first, second and third trimesters of their pregnancy. This was done to assess whether pregnancy alters vitamin D status in healthy women. During most times of the year there was no association between the 25-OHD levels and the stage of pregnancy, but between January and March there was a progressive fall in 25-OHD levels with each trimester. When 25-OHD levels were related to hours of possible sunlight exposure a negative association between 25-OHD levels and stage of pregnancy was noted only in subjects with the lowest possible exposure to sunlight. These observations suggest that pregnancy has an effect on vitamin D metabolism, but that in healthy Caucasian women these effects only become manifest where there is a low level of exposure to sunlight.