Detalhe da pesquisa
1.
Human cerebral vascular amyloid contains both antiparallel and parallel in-register Aß40 fibrils.
J Biol Chem
; 297(5): 101259, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34599967
2.
A Novel Transgenic Rat Model of Robust Cerebral Microvascular Amyloid with Prominent Vasculopathy.
Am J Pathol
; 188(12): 2877-2889, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30446159
3.
Mechanism of Nucleated Conformational Conversion of Aß42.
Biochemistry
; 54(27): 4197-207, 2015 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26069943
4.
Early-onset formation of parenchymal plaque amyloid abrogates cerebral microvascular amyloid accumulation in transgenic mice.
J Biol Chem
; 289(25): 17895-908, 2014 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24828504
5.
Conformational differences between two amyloid ß oligomers of similar size and dissimilar toxicity.
J Biol Chem
; 287(29): 24765-73, 2012 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22547072
6.
Evaluation of Copper Chelation Therapy in a Transgenic Rat Model of Cerebral Amyloid Angiopathy.
ACS Chem Neurosci
; 14(3): 378-388, 2023 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36651175
7.
rTg-D: A novel transgenic rat model of cerebral amyloid angiopathy Type-2.
Cereb Circ Cogn Behav
; 3: 100133, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36324401
8.
N-terminal domain of myelin basic protein inhibits amyloid beta-protein fibril assembly.
J Biol Chem
; 285(46): 35590-8, 2010 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20807757
9.
Diffuse white matter loss in a transgenic rat model of cerebral amyloid angiopathy.
J Cereb Blood Flow Metab
; 41(5): 1103-1118, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32791876
10.
Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease.
J Neurosci
; 29(25): 7957-65, 2009 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19553436
11.
AbetaPP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis.
J Neurosci
; 29(17): 5666-70, 2009 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-19403832
12.
Voluntary Wheel Running Reduces Amyloid-ß42 and Rescues Behavior in Aged Tg2576 Mouse Model of Alzheimer's Disease.
J Alzheimers Dis
; 73(1): 359-374, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31796673
13.
Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice.
J Neurosci
; 28(20): 5312-20, 2008 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18480287
14.
Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2.
J Neurosci
; 28(7): 1537-45, 2008 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18272675
15.
Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy.
Am J Pathol
; 173(2): 483-93, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18599612
16.
LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.
Neuron
; 43(3): 333-44, 2004 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-15294142
17.
Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid.
J Neurosci
; 27(12): 3057-63, 2007 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-17376966
18.
The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP.
J Alzheimers Dis
; 15(4): 571-87, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19096157
19.
Mutation of the Kunitz-type proteinase inhibitor domain in the amyloid ß-protein precursor abolishes its anti-thrombotic properties in vivo.
Thromb Res
; 155: 58-64, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28499154
20.
Intensive 'Brain Training' Intervention Fails to Reduce Amyloid Pathologies or Cognitive Deficits in Transgenic Mouse Models of Alzheimer's Disease.
J Alzheimers Dis
; 55(3): 1109-1121, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-27767989