1.
Bioorg Med Chem Lett
; 18(16): 4573-7, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18662872
RESUMO
A focused SAR exploration of the lead 4-aminoquinazoline TRPV1 antagonist 2 led to the discovery of compound 18. In rats, compound 18 is readily absorbed following oral dosing and demonstrates excellent in vivo potency and efficacy in an acute inflammatory pain model.