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1.
Pancreatology ; 20(5): 1011-1012, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32498972

RESUMO

The involvement of gastrointestinal system in SARS-CoV2 related disease, COVID-19, is increasingly recognized. COVID-19 associated pancreatic injury has been suggested, but its correlation with pancreatic disease is still unclear. In this case report, we describe the detection of SARS-CoV2 RNA in a pancreatic pseudocyst fluid sample collected from a patient with SARS-CoV2 associated pneumonia and a pancreatic pseudocyst developed as a complication of an acute edematous pancreatitis. The detection of SARS-CoV2 within the pancreatic collection arise the question of whether this virus has a tropism for pancreatic tissue and whether it plays a role in pancreatic diseases occurrence.


Assuntos
Betacoronavirus/química , Infecções por Coronavirus/complicações , Pseudocisto Pancreático/virologia , Pneumonia Viral/complicações , RNA Viral/análise , Idoso , COVID-19 , Feminino , Humanos , Pancreatite/complicações , Pandemias , SARS-CoV-2 , Síndrome Respiratória Aguda Grave/complicações , Síndrome Respiratória Aguda Grave/tratamento farmacológico , Carga Viral
2.
Clin Breast Cancer ; 21(3): e141-e149, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33012660

RESUMO

PURPOSE: To evaluate, in a series of early breast cancer (BC) patients treated with hypofractionated adjuvant radiotherapy (RT), whether N-terminal-pro hormone B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin I assay measurements can predict acute clinical or preclinical cardiotoxicity. PATIENTS AND METHODS: The study comprised 44 consecutive patients, who underwent conservative surgery with or without (neo)adjuvant chemotherapy and hypofractionated adjuvant RT. The RT schedule consisted in a total dose of 42.4 Gy in 16 fractions administered 5 days per week. Twenty-one patients received a subsequent boost to the tumor bed consisting of a total dose of 10 Gy in 4 fractions delivered via a direct electron field. All patients underwent 12-lead electrocardiogram, echocardiogram, and cardiac clinical examinations before RT to assess cardiovascular risk factors; these examinations were repeated yearly for 5 consecutive years. High-sensitivity cardiac troponin I and NT-proBNP were analyzed from serum samples at baseline, after delivery of the fourth and 16th RT fractions, and 12 months after treatment completion. RESULTS: No increase in cardiac troponin I and B-type natriuretic peptide levels related to left breast irradiation was observed. No statistical difference in NT-proBNP and high-sensitivity troponin I levels between left- and right-sided BC was found. An increase was observed of B-type natriuretic peptide levels at baseline, during treatment, and until 12 months after RT related to hypertension, with the P value near to the .05 threshold for age and chemotherapy. CONCLUSION: Conformational hypofractionated RT in left-sided BC may not cause acute myocardial damage. Early cardiac screening may be used to identify patients with cardiologic risk factors, patients who are older than 60 years, and patients who received chemotherapy that could result in clinically relevant cardiac pathologies.


Assuntos
Quimioterapia Adjuvante/efeitos adversos , Peptídeo Natriurético Encefálico/sangue , Fragmentos de Peptídeos/sangue , Hipofracionamento da Dose de Radiação , Neoplasias Unilaterais da Mama/radioterapia , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Biomarcadores/sangue , Cardiotoxicidade , Feminino , Coração/efeitos da radiação , Humanos , Pessoa de Meia-Idade , Estudos Prospectivos , Neoplasias Unilaterais da Mama/sangue , Neoplasias Unilaterais da Mama/patologia
3.
Clin Ter ; 158(2): 147-50, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17566516

RESUMO

As there are a number of possible causes of syncope, differentiation between cardiovascular disease, neurogenic disease and other disorders is mandatory. Cerebral arteriovenous malformations (AVMs) are tangled anastomoses of blood vessels of varying calibre in which arteriovenous shunting occurs in a central nidus, which is the area towards which multiple feeding arteries converge and from which enlarged veins drain. We describe a clinical case of syncope caused by a large AVM discovered in a 66-year-old woman. The symptoms were probably related to an epileptogenic mechanism since the syncope disappeared following the administration of antiepileptic therapy. The anatomical, pathological and clinical aspects of AVMs are discussed.


Assuntos
Malformações Arteriovenosas Intracranianas/complicações , Síncope/etiologia , Feminino , Humanos , Pessoa de Meia-Idade , Recidiva
4.
Biol Psychiatry ; 18(6): 695-706, 1983 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-6871303

RESUMO

Intravenous clomipramine and oral clomipramine at a daily dose of 2 mg/kg body weight were compared in a double-blind study of 40 inpatients with primary depressive illness. No significant differences between the two routes of clomipramine administration were found, either in response or in side effects. Steady state was not attained at the 4th week of treatment in 30% of patients. However, combined plasma levels of clomipramine (CI) plus desmethylclomipramine (DMCI) were similar in the two groups at all stages of treatment. The only significant pharmacokinetic difference that was found was in the ratio of DMCI to CI, which was higher among the patients who received the drug orally, but this did not correlate with clinical response. Conversely, Day 28 plasma concentrations of CI, DMCI, and the sum CI + DMCI were significantly related to clinical outcome in the patients treated orally. Among the patients who received the drug intravenously only CI was significantly associated with the percentage reduction of symptoms. By pooling the two groups, CI, DMCI, and their sum all bore relationships to clinical response significant at the 0.01 level.


Assuntos
Clomipramina/uso terapêutico , Transtorno Depressivo/tratamento farmacológico , Administração Oral , Clomipramina/análogos & derivados , Clomipramina/sangue , Transtorno Depressivo/sangue , Método Duplo-Cego , Humanos , Injeções Intravenosas , Pessoa de Meia-Idade
5.
J Thorac Cardiovasc Surg ; 91(3): 467-9, 1986 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-2936934

RESUMO

Ninety consecutive patients with atrioventricular canal were studied to identify the association between left-sided obstructive lesions and Down's syndrome. Three groups were recognized: Group I, 76 patients with atrioventricular canal and no left-sided obstructions; Group II, nine patients with atrioventricular canal and left-sided inlet obstructions; Group III, five patients with atrioventricular canal and left-sided outlet obstructions. Of the 90 patients studied, 47 had Down's syndrome and only one of these had a left-sided obstructive lesion. Of 43 without Down's syndrome, 13 or 30% had left-sided obstructive lesions with predominating lesions at the inlet level caused by right ventricular dominance.


Assuntos
Síndrome de Down/complicações , Comunicação Atrioventricular/complicações , Defeitos dos Septos Cardíacos/complicações , Ventrículos do Coração/anormalidades , Coartação Aórtica/complicações , Estenose da Valva Aórtica/complicações , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino
6.
Cardiovasc Pathol ; 7(1): 39-46, 1998.
Artigo em Inglês | MEDLINE | ID: mdl-25989962

RESUMO

This report describes the case of two siblings who underwent heart transplantation with a clinical diagnosis of mildly dilated cardiomyopathy. Pathological examination of the hearts revealed arrhythmogenic (right ventricular) cardiomyopathy, adipose type, associated with biventricular myocarditis in both the recipients' hearts. Family history revealed the occurrence of dilated cardiomyopathy and myocarditis in their father and his sister. To our knowledge, this is the first pathological demonstration of arrhythmogenic cardiomyopathy and myocarditis in siblings. We think this report substantiates a genetic ground for the relationship between these two heart conditions.

7.
Dig Liver Dis ; 34(12): 866-9, 2002 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-12643296

RESUMO

An increased incidence of coeliac disease has recently been reported in patients with idiopathic dilated cardiomyopathy. This report deals with three patients with idiopathic dilated cardiomyopathy and coeliac disease who underwent clinical and laboratory evaluation to establish the effect of a gluten-free diet on cardiac performance. Two patients observed the gluten-free diet regimen very strictly, and, after a 28-month follow-up period, showed an improvement in echocardiographic parameters as well as in cardiological features and quality of life, as evaluated by the Minnesota Living with Heart Failure questionnaire and the Gastrointestinal Symptom Rating Scale questionnaire. The third patient did not observe the gluten-free diet and presented a worsening in the echocardiographic parameters and cardiological symptoms which required supplementary drug therapy. These preliminary data appear to suggest that the gluten-free diet may have a beneficial effect on cardiac performance in patients with idiopathic dilated cardiomyopathy.


Assuntos
Cardiomiopatia Dilatada/complicações , Doença Celíaca/complicações , Doença Celíaca/dietoterapia , Adulto , Cardiomiopatia Dilatada/fisiopatologia , Ecocardiografia , Seguimentos , Glutens/administração & dosagem , Humanos , Masculino , Qualidade de Vida
8.
Funct Neurol ; 6(3): 275-8, 1991.
Artigo em Inglês | MEDLINE | ID: mdl-1743542

RESUMO

Pure autonomic failure (PAF) is a rare syndrome characterized by a primitive failure of the autonomic nervous system (ANS). We have studied a 53-year old woman suffering from PAF by using ANS provocative tests investigating the cardiovascular system (standing up test, controlled ventilation, Valsalva manoeuvre, handgrip test, cold pressor test, mental stress test, plasma catecholamine levels), tests investigating the intrinsic ocular innervation (pupil reactivity), and the bladder function (urodynamic tests). Our results have shown abnormalities of all the studied parameters and they have also confirmed that these patients need a multidisciplinary autonomic evaluation to correctly identify the syndrome.


Assuntos
Doenças do Sistema Nervoso Autônomo/fisiopatologia , Exame Neurológico/métodos , Nível de Alerta/fisiologia , Sistema Nervoso Autônomo/fisiopatologia , Doenças do Sistema Nervoso Autônomo/diagnóstico , Pressão Sanguínea/fisiologia , Catecolaminas/sangue , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade , Reflexo Pupilar/fisiologia , Síndrome , Urodinâmica/fisiologia
9.
Funct Neurol ; 2(4): 523-7, 1987.
Artigo em Inglês | MEDLINE | ID: mdl-3443377

RESUMO

The authors consider the possible relationship between the autonomic functions and the contingent Negative Variation (CNV). This relationship has been found both in psychopathological conditions and after the administration of psychotropic drugs. Some preliminary data are reported on the correlations observed between CNV and the autonomic activation (R-R interval) during a sodium lactate infusion.


Assuntos
Nível de Alerta/fisiologia , Variação Contingente Negativa , Eletrofisiologia , Sistema Nervoso Autônomo/fisiologia , Encéfalo/fisiologia , Frequência Cardíaca/efeitos dos fármacos , Humanos , Lactatos/farmacologia , Ácido Láctico , Pânico/fisiologia
10.
Minerva Cardioangiol ; 49(1): 15-22, 2001 Feb.
Artigo em Inglês, Italiano | MEDLINE | ID: mdl-11360881

RESUMO

BACKGROUND: The aim of the study was to investigate the behaviour of plasma levels of endothelin-1 (ET-1), an endothelial peptide with vasoconstrictive and proliferative actions, in patients with cardiac transplantation and in chronic treatment with cyclosporine A, some of whom became hypertensive after cardiac transplantation. METHODS: We studied: 1) 18 consecutive patients (15 M, 3F; mean age 53 +/- 7 yrs) who underwent cardiac transplantation about six months ago at least (range 6-108 months); 2) 15 patients with essential arterial hypertension (10 M, 5 F; mean age 42 +/- 15 yrs) without organ damage; 3) 21 normal subjects (15 M, 6 F; mean age 31 +/- 12 yrs). Plasma levels of ET-1 (RIA), haemodynamic and functional renal parameters were determined in all groups and plasma levels of cyclosporine were measured in patients with cardiac transplantation. RESULTS: ET-1 was higher in patients with cardiac transplantation than in the other two groups (p < 0.05); instead there was no difference between patients with essential arterial hypertension and controls (p>0.05). A statistical difference was found between circulating ET-1 in hypertensive transplanted patients. In heart transplanted patients a positive and significative correlation was found between plasma levels of ET-1 and systolic (r=0.525; p<0.037) blood pressure.


Assuntos
Ciclosporinas/uso terapêutico , Endotelina-1/sangue , Transplante de Coração , Hipertensão/sangue , Imunossupressores/uso terapêutico , Adulto , Idoso , Análise de Variância , Ciclosporinas/sangue , Endotelina-1/fisiologia , Feminino , Hemodinâmica , Humanos , Hipertensão/fisiopatologia , Imunossupressores/sangue , Rim/fisiopatologia , Masculino , Pessoa de Meia-Idade , Análise de Regressão
11.
Recenti Prog Med ; 83(6): 341-3, 1992 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-1496182

RESUMO

An unusual case of Herpes simplex virus (HSV) pneumonia in a heart transplant recipient receiving chronic immunosuppressive therapy is reported. This infection presented an indolent course manifested by a chronic left pulmonary infiltrate unresponsive to antibiotic therapy and mild hypoxemia. Death eventually occurred as a consequence of an other infectious complication of the postoperative period. The HSV etiology of the necrotizing pneumonia observed at autopsy was established on the basis of histologic findings.


Assuntos
Transplante de Coração , Herpes Simples/etiologia , Pneumonia Viral/etiologia , Adulto , Autopsia , Herpes Simples/patologia , Humanos , Pulmão/patologia , Masculino , Pneumonia Viral/patologia , Complicações Pós-Operatórias , Choque Séptico/etiologia
12.
J Hypertens Suppl ; 6(1): S63-7, 1988 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-3216241

RESUMO

In order to evaluate age-related differences in autonomic nervous system control of the cardiovascular system, we studied two groups of healthy subjects of different ages by means of an autonomic function test, the posture test, applied before and after meals. Our results suggest that the reactions of the cardiovascular system to physiological stimuli such as meals or standing up, differ in elderly compared with young people, partly because age modifies the balance between the parasympathetic and the orthosympathetic nervous systems. In the elderly there is a progressive decline in parasympathetic function, which controls the initial heart rate response to standing up. Splanchnic blood pooling and possible hormonal secretions after meals may produce a drop in blood pressure due to cardiovascular modifications in the elderly. Other factors contributing to the different patterns found in the elderly may be reduced compliance of the vascular tree, a decreased baroreceptor response and decreased sympathetic activity.


Assuntos
Sistema Nervoso Autônomo/fisiologia , Pressão Sanguínea , Ingestão de Alimentos , Frequência Cardíaca , Postura , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Fenômenos Fisiológicos Cardiovasculares , Sistema Cardiovascular/inervação , Eletrocardiografia , Humanos , Sistema Nervoso Parassimpático/fisiologia , Fatores de Tempo
15.
Cardiologia ; 38(10): 635-42, 1993 Oct.
Artigo em Italiano | MEDLINE | ID: mdl-8111756

RESUMO

We have studied the relationship between left ventricular segmental wall motion evaluated by means of biplane left ventricular cineangiography and the myocardial infarct size estimated using Selvester's scoring system based on the QRS of the electrocardiogram. Seventy consecutive patients with old myocardial infarction were recruited. All patients underwent diagnostic retrograde left heart catheterization including left ventriculography and selective coronary arteriography. Nineteen patients were excluded from the study due to intraventricular conduction disturbances and left ventricular hypertrophy. Of the remaining 51 patients, aged 33-76 years (mean 56 years), 31 had inferior or postero-inferior myocardial infarction (Group 1); 7 patients had combined anterior and inferior myocardial infarction (Group 2); 13 patients had anterior or antero-septal myocardial infarction (Group 3). The analysis of left ventricular segmental wall motion was performed according to the Collaborative Studies in Coronary Artery Surgery assigning at hypokinesia, akinesia and dyskinesia 1, 2 and 3 points, respectively. The values of statistical correlations between QRS scoring system and ventricular scoring were: r = 0.85 (Group 1); r = 0.78 (Group 2); r = 0.70 (Group 3). Our data indicate that Selvester's scoring system may provide useful information on functional status and on the extent of left ventricular wall motion abnormalities in patients with previous myocardial infarction.


Assuntos
Eletrocardiografia/métodos , Infarto do Miocárdio/fisiopatologia , Função Ventricular Esquerda , Adulto , Idoso , Cateterismo Cardíaco , Angiografia Coronária , Eletrocardiografia/estatística & dados numéricos , Feminino , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/diagnóstico , Infarto do Miocárdio/epidemiologia , Fatores de Tempo
16.
Boll Soc Ital Biol Sper ; 59(5): 621-5, 1983 May 30.
Artigo em Italiano | MEDLINE | ID: mdl-6882560

RESUMO

Determinations of erythrocyte glucose-6-phosphate dehydrogenase, pyruvate kinase and glucose-phosphate isomerase activities have been carried out in jaundiced and non-jaundiced newborn infants at birth and after 5 days of life. Only hyperbilirubinemias of unknown etiology have been considered. Previous investigations have demonstrated that erythrocyte age dependent enzyme activities decrease in the healthy newborn during the first week of life. Following the results of the present paper, jaundiced newborns do not show such a decrease, since a statistically significant difference between paired data of glucose-6-phosphate dehydrogenase and pyruvate kinase in jaundiced and non-jaundiced newborns have been found. It is likely that the lack of decrease of enzyme activities in the jaundiced infants depend upon the loss of oldest red cells with low glucose-6-phosphate dehydrogenase and pyruvate kinase. Our observation suggests the occurrence of a slight hemolysis in newborn infants with hyperbilirubinemia of unknown etiology.


Assuntos
Eritrócitos/citologia , Icterícia Neonatal/sangue , Envelhecimento Eritrocítico , Glucose-6-Fosfato Isomerase/sangue , Glucosefosfato Desidrogenase/sangue , Humanos , Recém-Nascido , Piruvato Quinase/sangue
17.
Boll Soc Ital Biol Sper ; 59(5): 626-30, 1983 May 30.
Artigo em Italiano | MEDLINE | ID: mdl-6882561

RESUMO

Recently attention has been called on the possible role of acidosis in the increased methemoglobin formation in the erythrocyte of newborn infant. In the present paper the relations between acidosis and methemoglobin content in the red cells of newborns has been investigated. No significant differences between the percent of methemoglobin in the normal newborns and percent of methemoglobin in the newborns with acidosis has been found. In addition, no correlations between the base excess and percent of methemoglobin has been observed. On the contrary, two newborns with low glucose-6-phosphate dehydrogenase activity demonstrated a significantly increased methemoglobin content in their red cells. The results of our study do not confirm a key role of acidosis in the mechanism of methemoglobin formation in the neonate. It is likely than impairment of red cell metabolism should be the main factor in the formation of methemoglobin in the first days of life.


Assuntos
Acidose/complicações , Doenças do Recém-Nascido/complicações , Metemoglobinemia/complicações , Eritrócitos/análise , Feminino , Glucosefosfato Desidrogenase/sangue , Humanos , Recém-Nascido , Masculino
18.
Riv Neurol ; 54(5): 340-6, 1984.
Artigo em Italiano | MEDLINE | ID: mdl-6505545

RESUMO

The authors present a case of syndrome of the orbital apex subsequent to a fibrous dysplasia in malignant evolution; they underline the usefulness of T.A.C. in the case, generally extremely rare, of such transformation.


Assuntos
Displasia Fibrosa Óssea/complicações , Doenças Orbitárias/etiologia , Sarcoma/etiologia , Neoplasias Cranianas/etiologia , Crânio , Displasia Fibrosa Óssea/diagnóstico por imagem , Displasia Fibrosa Óssea/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia , Crânio/patologia
19.
G Ital Cardiol ; 17(11): 992-4, 1987 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-3446572

RESUMO

Clinical, instrumental and post-mortem studies were carried out in a patient with intractable cardiac failure, whose death was attribute to Weil's syndrome. A post-mortem examination showed the presence of numerous petechiae on the heart layers and diffuse lymphomonocytic infiltrates in the myocardium, epicardium and endocardium. We suggest that in patients affected by leptospirosis--an endemic disease with a possible fatal outcome--it is necessary to determine carefully any involvement of the cardiovascular system which may play a determinant role in the evolution of the disease.


Assuntos
Insuficiência Cardíaca/etiologia , Doença de Weil/complicações , Insuficiência Cardíaca/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Miocárdio/patologia , Doença de Weil/patologia
20.
Lancet ; 354(9174): 222-3, 1999 Jul 17.
Artigo em Inglês | MEDLINE | ID: mdl-10421311

RESUMO

We examined 52 patients with idiopathic cardiomyopathy (IDCM) for coeliac disease. Three of them had coeliac disease, suggesting that prevalence of coeliac disease in IDCM patients is increased.


Assuntos
Cardiomiopatia Dilatada/complicações , Doença Celíaca/complicações , Adulto , Doença Celíaca/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência
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