Detalhe da pesquisa
1.
Neratinib could be effective as monotherapy or in combination with trastuzumab in HER2-low breast cancer cells and organoid models.
Br J Cancer
; 2024 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38600326
2.
A randomised evaluation of low-dose Ara-C plus pegylated recombinant arginase BCT-100 versus low dose Ara-C in older unfit patients with acute myeloid leukaemia: Results from the LI-1 trial.
Br J Haematol
; 200(5): 573-578, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36413792
3.
Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment.
Cancer Immunol Immunother
; 72(3): 543-560, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-35962843
4.
Characterizing EBV-associated lymphoproliferative diseases and the role of myeloid-derived suppressor cells.
Blood
; 137(2): 203-215, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33443553
5.
TGF-ß orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer.
Cancer Immunol Immunother
; 71(7): 1583-1596, 2022 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34727230
6.
Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A.
Nat Immunol
; 11(11): 1039-46, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20890286
7.
Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity.
Blood
; 136(10): 1155-1160, 2020 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32573723
8.
Targeting the arginine metabolic brake enhances immunotherapy for leukaemia.
Int J Cancer
; 145(8): 2201-2208, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30485425
9.
The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated-recombinant arginase I BCT-100.
Int J Cancer
; 142(7): 1490-1502, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29168171
10.
Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target.
Blood
; 125(15): 2386-96, 2015 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25710880
11.
Molecular basis and current strategies of therapeutic arginine depletion for cancer.
Int J Cancer
; 139(3): 501-9, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26913960
12.
Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment.
Blood
; 122(5): 749-58, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23733335
13.
PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults.
Front Oncol
; 14: 1296576, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38357205
14.
Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment.
Blood Adv
; 7(9): 1754-1761, 2023 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36521029
15.
G-CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment.
Clin Transl Immunology
; 11(5): e1395, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35602884
16.
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.
J Clin Invest
; 118(12): 4036-48, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19033672
17.
B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo.
Proc Natl Acad Sci U S A
; 105(24): 8345-50, 2008 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-18550831
18.
Targeting Amino Acid Metabolic Vulnerabilities in Myeloid Malignancies.
Front Oncol
; 11: 674720, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34094976
19.
Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells.
J Clin Invest
; 116(10): 2777-90, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17016559
20.
MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers.
EBioMedicine
; 47: 235-246, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-31462392