Detalhe da pesquisa
1.
Characterization of Polysorbate Ester Fractions and Implications in Protein Drug Product Stability.
Mol Pharm
; 17(7): 2345-2353, 2020 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32442382
2.
Degradation Mechanisms of Polysorbate 20 Differentiated by 18O-labeling and Mass Spectrometry.
Pharm Res
; 34(1): 84-100, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27738952
3.
Understanding Particle Formation: Solubility of Free Fatty Acids as Polysorbate 20 Degradation Byproducts in Therapeutic Monoclonal Antibody Formulations.
Mol Pharm
; 12(11): 3792-804, 2015 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26419285
4.
Polysorbate 20 Degradation in Biopharmaceutical Formulations: Quantification of Free Fatty Acids, Characterization of Particulates, and Insights into the Degradation Mechanism.
Mol Pharm
; 12(11): 3805-15, 2015 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26419339
5.
Solubility Challenges in High Concentration Monoclonal Antibody Formulations: Relationship with Amino Acid Sequence and Intermolecular Interactions.
Mol Pharm
; 12(11): 3896-907, 2015 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26407030
6.
Comparison of binding characteristics and in vitro activities of three inhibitors of vascular endothelial growth factor A.
Mol Pharm
; 11(10): 3421-30, 2014 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25162961
7.
Weak interactions govern the viscosity of concentrated antibody solutions: high-throughput analysis using the diffusion interaction parameter.
Biophys J
; 103(1): 69-78, 2012 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22828333
8.
Extended Characterization and Impact of Visible Fatty Acid Particles - A Case Study With a mAb Product.
J Pharm Sci
; 110(3): 1093-1102, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33271136
9.
Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease.
Sci Transl Med
; 13(593)2021 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33980574
10.
A therapeutic antibody and its antigen form different complexes in serum than in phosphate-buffered saline: a study by analytical ultracentrifugation.
Anal Biochem
; 388(2): 279-87, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19289095
11.
A Rapid High-Sensitivity Reversed-Phase Ultra High Performance Liquid Chromatography Mass Spectrometry Method for Assessing Polysorbate 20 Degradation in Protein Therapeutics.
J Pharm Sci
; 108(9): 2880-2886, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31054888
12.
Characterization of protein aggregation: the case of a therapeutic immunoglobulin.
Biochim Biophys Acta
; 1774(1): 146-53, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17142116
13.
Detection and characterization of protein aggregates by fluorescence microscopy.
Int J Pharm
; 329(1-2): 37-45, 2007 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17005340
14.
Where disease pathogenesis meets protein formulation: renal deposition of immunoglobulin aggregates.
Eur J Pharm Biopharm
; 62(2): 121-30, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16221544
15.
Quality by Design Approaches to Formulation Robustness-An Antibody Case Study.
J Pharm Sci
; 105(5): 1667-1675, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27001536
16.
Analytical Ultracentrifugation and Its Role in Development and Research of Therapeutical Proteins.
Methods Enzymol
; 562: 441-76, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26412663
17.
Compatibility and stability of pertuzumab and trastuzumab admixtures in i.v. infusion bags for coadministration.
J Pharm Sci
; 102(3): 794-812, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23225178
18.
Assessment and significance of protein-protein interactions during development of protein biopharmaceuticals.
Biophys Rev
; 5(2): 121-136, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28510158
19.
Characterization of particles in protein solutions: reaching the limits of current technologies.
AAPS J
; 12(4): 708-15, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20953747
20.
New methods allowing the detection of protein aggregates: a case study on trastuzumab.
MAbs
; 1(2): 142-50, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-20061815