Detalhe da pesquisa
1.
High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 68(Pt 4): 404-8, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22505407
2.
Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity.
J Autoimmun
; 36(3-4): 201-9, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21439785
3.
1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors: separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen pka.
Bioorg Med Chem Lett
; 21(3): 932-5, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21227690
4.
Identification of potent, soluble, and orally active TRPV1 antagonists.
Bioorg Med Chem Lett
; 21(8): 2559-63, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21435873
5.
Structure-activity studies of a novel series of isoxazole-3-carboxamide derivatives as TRPV1 antagonists.
Bioorg Med Chem Lett
; 21(3): 892-8, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21236666
6.
Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles.
Bioorg Med Chem Lett
; 21(15): 4652-7, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21723725
7.
Dioxo-triazines as a novel series of cathepsin K inhibitors.
Bioorg Med Chem Lett
; 20(5): 1488-90, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20153187
8.
4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important.
Bioorg Med Chem Lett
; 20(15): 4507-10, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20580231
9.
Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors.
Bioorg Med Chem Lett
; 20(23): 6890-4, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21030256
10.
2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors.
Bioorg Med Chem Lett
; 20(15): 4447-50, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20594841
11.
6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors.
Bioorg Med Chem Lett
; 20(15): 4350-4, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20598883
12.
Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors.
Bioorg Med Chem Lett
; 20(5): 1524-7, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20149657
13.
Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: improving selectivity over hERG.
Bioorg Med Chem Lett
; 20(21): 6237-41, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20843687