RESUMO
OBJECTIVE: This study aimed to carry out a bibliometric analysis of primary ovarian insufficiency (POI) from 2010 to 2020 and to reveal the research status and hotspots in the future. METHOD: A total of 3087 articles and reviews related to POI published from 2010 to 2020 retrieved from the Web of Science Core Collection were used for bibliometric analysis. CiteSpace and VOSviewer were adopted to analyze countries and regions, organizations, authors, journals, keywords and co-cited references. RESULTS: The number of publications about POI increased year by year. The USA produced the largest number of publications and the most influence in this field. The main research directions of POI can be roughly divided into four aspects according to the analysis of keywords and co-cited references: genetic research of POI; stem cell therapy for patients with POI; prediction of ovarian function; and fertility preservation of cancer patients. Genetic research and stem cell therapy may become research hotspots in the future. CONCLUSION: This study might be the first bibliometric study to analyze publications of POI from multiple indicators, in order to provide new opinions for the research trends and possible hotspots of POI.
Assuntos
Pesquisa Biomédica , Insuficiência Ovariana Primária , Bibliometria , Feminino , Previsões , Humanos , Insuficiência Ovariana Primária/terapia , PublicaçõesRESUMO
The novel KIR3DL1*079 allele differs from KIR3DL1*0150201 by a single mutation at CDS nt1119 G>T.
Assuntos
Alelos , Polimorfismo de Nucleotídeo Único , Receptores KIR3DL1/genética , Substituição de Aminoácidos , Sequência de Bases , China , Códon , Éxons , Expressão Gênica , Testes Genéticos , Humanos , Dados de Sequência Molecular , Tipagem Molecular , Receptores KIR3DL1/imunologia , Alinhamento de SequênciaRESUMO
The novel KIR2DL2*013 allele differs from the closest allele KIR2DL2*00302 by two non-synonymous mutations.
Assuntos
Alelos , Povo Asiático/genética , Etnicidade/genética , Receptores KIR2DL2/genética , Sequência de Bases , China , Humanos , Dados de Sequência Molecular , Alinhamento de SequênciaRESUMO
OBJECTIVE: To investigate the efficacy of different electrical stimulation (ES) therapies in pain relief of patients with knee osteoarthritis (OA). METHOD: Electronic databases including MEDLINE, Embase and Cochrane Library were searched through for randomized controlled trials (RCTs) comparing any ES therapies with control interventions (sham or blank) or with each other. Bayesian network meta-analysis was used to combine both the direct and indirect evidence on treatment effectiveness. RESULTS: 27 trials and six kinds of ES therapies, including high-frequency transcutaneous electrical nerve stimulation (h-TENS), low-frequency transcutaneous electrical nerve stimulation (l-TENS), neuromuscular electrical stimulation (NMES), interferential current (IFC), pulsed electrical stimulation (PES), and noninvasive interactive neurostimulation (NIN), were included. IFC is the only significantly effective treatment in terms of both pain intensity and change pain score at last follow-up time point when compared with the control group. Meanwhile, IFC showed the greatest probability of being the best option among the six treatment methods in pain relief. These estimates barely changed in sensitivity analysis. However, the evidence of heterogeneity and the limitation in sample size of some studies could be a potential threat to the validity of results. CONCLUSION: IFC seems to be the most promising pain relief treatment for the management of knee OA. However, evidence was limited due to the heterogeneity and small number of included trials. Although the recommendation level of the other ES therapies is either uncertain (h-TENS) or not appropriate (l-TENS, NMES, PES and NIN) for pain relief, it is likely that none of the interventions is dangerous. LEVEL OF EVIDENCE: Levelâ ¡, systematic review and network meta-analysis of RCTs.
Assuntos
Artralgia/etiologia , Artralgia/terapia , Osteoartrite do Joelho/complicações , Manejo da Dor/métodos , Estimulação Elétrica Nervosa Transcutânea , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do TratamentoRESUMO
KIR2DL3*027 differs from the closest allele KIR2DL3*00101 by a nonsynonymous mutation in exon 7.
Assuntos
Alelos , Éxons , Mutação , Receptores KIR2DL3/genética , Povo Asiático , Sequência de Bases , China , Humanos , Dados de Sequência MolecularRESUMO
KIR2DL3*029 differs from the closest allele KIR2DL3*00101 by a single missense mutation at CDS nt505 C > A.
Assuntos
Alelos , Mutação de Sentido Incorreto , Receptores KIR2DL3/genética , Povo Asiático/etnologia , HumanosRESUMO
KIR2DL3*026 differs from the closest allele KIR2DL3*00101 by a nonsynonymous mutation in exon 4.
Assuntos
Alelos , Éxons , Mutação , Receptores KIR2DL3/genética , Povo Asiático , Sequência de Bases , China , Humanos , Dados de Sequência MolecularRESUMO
We describe here a novel null allele of human leukocyte antigen gene, A*11:69N, which was initially found in a blood donor from China.
Assuntos
Alelos , Bases de Dados de Ácidos Nucleicos , Antígenos HLA-A/genética , Sequência de Bases , Humanos , Masculino , Dados de Sequência MolecularRESUMO
KIR2DL3*030 differs from the closest allele, KIR2DL3*00101, by a single missense mutation at CDS.
Assuntos
Alelos , Mutação de Sentido Incorreto , Receptores KIR2DL3/genética , Povo Asiático/etnologia , HumanosRESUMO
The novel KIR2DL3*031 allele differs from KIR2DL3*00101 by a synonymous mutation and a non-synonymous mutation.
Assuntos
Alelos , Mutação , Receptores KIR2DL3/genética , Povo Asiático/etnologia , HumanosRESUMO
The novel KIR2DL3*025 allele differs from the closest allele KIR2DL3*0010101 by a non-synonymous mutation at CDS nt280 C>A in exon 4.
Assuntos
Alelos , Mutação , Receptores KIR2DL3/genética , Povo Asiático/etnologia , Feminino , Humanos , MasculinoRESUMO
KIR2DL3*00110 differs from KIR2DL3*00101 by a single silent mutation at coding sequence (CDS) nt618 A>C in exon 5.
Assuntos
Alelos , Mutação de Sentido Incorreto , Receptores KIR2DL3/genética , Povo Asiático/etnologia , HumanosRESUMO
The novel HLA-DPB1*166:01 allele differs from the closest allele DPB1*152:01 by a single missense mutation at CDS nt 315G>A in exon 2.
Assuntos
Alelos , Bases de Dados de Ácidos Nucleicos , Éxons , Cadeias HLA-DRB1/genética , Mutação de Sentido Incorreto , Sequência de Bases , Análise Mutacional de DNA , Teste de Histocompatibilidade , Humanos , Dados de Sequência MolecularRESUMO
BACKGROUND: To investigate the efficacy of continuous and pulsed ultrasound (US) in the management of knee osteoarthritis (OA). DESIGN: This systematic review and network meta-analysis covered 12 trials in total. Electronic databases including MEDLINE, Embase and Cochrane Library were searched through to identify randomized controlled trials comparing the two modes of US with control interventions (sham or blank) or with each other. Bayesian network meta-analysis was used to integrate both the direct and indirect evidences on treatment effectiveness. RESULTS: Pulsed US (PUS) is more effective in both pain relief and function improvement when compared with the control group; but for continuous US (CUS), there is only a significant difference in pain relief in comparison with the control group. In addition, no matter in terms of pain intensity or function at the last follow-up time point, PUS always exhibited a greater probability of being the preferred mode. However, the evidence of heterogeneity and the limitation in sample size of some studies could be a potential threat to the validity of results. CONCLUSIONS: Our findings indicated that PUS, with a greater probability of being the preferred mode, is more effective in both pain relief and function improvement when compared with the control group. However, CUS could only be considered as a pain relief treatment in the management of knee OA. The findings also confirmed that none of these modes is dangerous. LEVEL OF EVIDENCE: Level II, systematic review and network meta-analysis of randomized controlled trials.
Assuntos
Osteoartrite do Joelho/terapia , Manejo da Dor/métodos , Terapia por Ultrassom/métodos , Humanos , Resultado do TratamentoRESUMO
MICA*069 differs from MICA*010:01 by one nucleotide at position 1118 within exon 6.
Assuntos
Alelos , Antígenos de Histocompatibilidade Classe I/genética , Mutação Puntual , Povo Asiático/genética , Sequência de Bases , Doadores de Sangue , Éxons , Antígenos de Histocompatibilidade Classe I/imunologia , Teste de Histocompatibilidade , Humanos , Dados de Sequência MolecularRESUMO
The novel HLA-DPB1*140:01 variant allele differs from the closest allele DPB1*05:01:01 by single nucleotide change at genomic nt 4898G>C in exon 2.
Assuntos
Cadeias beta de HLA-DP/genética , Alelos , Povo Asiático/genética , Sequência de Bases , China , DNA/genética , Humanos , Dados de Sequência Molecular , Homologia de Sequência do Ácido Nucleico , Doadores de TecidosRESUMO
MICA*066, a novel MICA allele identified in HLA/MICA typing of a unrelated donor hematopoietic stem cell transplantation donor-patient pair.
Assuntos
Alelos , Antígenos de Histocompatibilidade Classe I/genética , Polimorfismo de Nucleotídeo Único , Substituição de Aminoácidos , Povo Asiático , Sequência de Bases , Códon , Éxons , Transplante de Células-Tronco Hematopoéticas , Antígenos de Histocompatibilidade Classe I/imunologia , Teste de Histocompatibilidade , Humanos , Íntrons , Dados de Sequência Molecular , Análise de Sequência de DNA , Homologia de Sequência do Ácido Nucleico , TransplanteRESUMO
HLA-B plays an important role in unrelated donor hematopoietic stem cell transplantation.
Assuntos
Povo Asiático/genética , Antígenos HLA-B/genética , Alelos , Sequência de Aminoácidos , Sequência de Bases , Clonagem Molecular , Antígenos HLA-B/sangue , Humanos , Dados de Sequência Molecular , Reação em Cadeia da Polimerase , Análise de Sequência de DNA , Homologia de Sequência de Aminoácidos , Homologia de Sequência do Ácido NucleicoRESUMO
A novel HLA-C*01 variant allele differs from the closest allele C*01:02:01 by single nucleotide change at coding sequence nt 316 C>T (codon 82 CGC>TGC) in exon 2, which causes an amino acid change Arg82Cys.
Assuntos
Antígenos HLA-C/genética , Alelos , Povo Asiático , Sequência de Bases , Teste de Histocompatibilidade , Humanos , Dados de Sequência Molecular , Análise de Sequência de DNARESUMO
The novel HLA-C*01:38 variant allele differs from the closest allele C*01:02:01 by a single nucleotide change at coding sequence (CDS) nt 430 G>A (codon 120 GGC>AGC) in exon 3, which causes an amino acid change Gly120Ser.