Detalhe da pesquisa
1.
Inhibition of Interleukin-23-Mediated Inflammation with a Novel Small Molecule Inverse Agonist of RORγt.
J Pharmacol Exp Ther
; 371(1): 208-218, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31375639
2.
Placental ABC Transporters: Biological Impact and Pharmaceutical Significance.
Pharm Res
; 33(12): 2847-2878, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27644937
3.
Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors.
Bioorg Med Chem Lett
; 26(9): 2297-302, 2016 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27020302
4.
A Simplified Method for Determining Blood-to-Plasma Ratios in vitro and ex vivo by Matrix Matching with Blank Blood or Plasma.
Drug Metab Bioanal Lett
; 16(2): 113-120, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37592774
5.
Integrity and efficiency: AbbVie's journey of building an integrated nonregulated bioanalytical laboratory.
Bioanalysis
; 15(3): 161-176, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36961367
6.
Global Analysis of Models for Predicting Human Absorption: QSAR, In Vitro, and Preclinical Models.
J Med Chem
; 64(13): 9389-9403, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34152772
7.
Paclitaxel succinate analogs: Anionic and amide introduction as a strategy to impart blood-brain barrier permeability.
Bioorg Med Chem Lett
; 18(22): 5971-4, 2008 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18926701
8.
Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis.
J Med Chem
; 61(4): 1436-1449, 2018 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29251932
9.
In Silico Absorption, Distribution, Metabolism, Excretion, and Pharmacokinetics (ADME-PK): Utility and Best Practices. An Industry Perspective from the International Consortium for Innovation through Quality in Pharmaceutical Development.
J Med Chem
; 60(22): 9097-9113, 2017 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28609624
10.
In silico, in vitro and in situ models to assess interplay between CYP3A and P-gp.
Curr Drug Metab
; 12(8): 750-73, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21568936
11.
TCP-FA4: a derivative of tranylcypromine showing improved blood-brain permeability.
Biochem Pharmacol
; 78(11): 1412-7, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19679106
12.
(3R,5S,7as)-(3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol, a novel neuroprotective agent.
J Med Chem
; 52(23): 7537-43, 2009 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19728715
13.
A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicity.
Bioorg Med Chem Lett
; 17(7): 1984-90, 2007 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17276679
14.
Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells.
Bioorg Med Chem Lett
; 16(3): 495-8, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16289636