RESUMO
Secondary cutaneous dissemination from an orbital diffuse large B cell lymphoma has not been described before. The authors report an unusual case of anaplastic variant of diffuse large B cell lymphoma which primarily presented in the orbit and during the course of disease had subcutaneous dissemination.
Assuntos
Linfoma Difuso de Grandes Células B/patologia , Neoplasias Orbitárias/patologia , Neoplasias Cutâneas/patologia , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Ciclofosfamida/uso terapêutico , Doxorrubicina/uso terapêutico , Humanos , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Neoplasias Orbitárias/tratamento farmacológico , Prednisolona/uso terapêutico , Neoplasias Cutâneas/tratamento farmacológico , Tomografia Computadorizada por Raios X , Vincristina/uso terapêuticoRESUMO
Primitive neuroectodermal tumor is a small round cell malignancy which rarely involves the orbit. We report a case of a two-year old male child presenting as unilateral eccentric proptosis with extraconal and intraconal mass, diagnosed as primary peripheral primitive neuroectodermal tumor (pPPNET) on histopathology and immunohistochemistry. There is no defined consensus in the management of these tumors due to its rare presentation. We describe its distinguishing features with emphasis on multimodal and aggressive treatment approach which ensures appropriate management of these cases.
Assuntos
Antineoplásicos/uso terapêutico , Tumores Neuroectodérmicos Primitivos Periféricos/radioterapia , Neoplasias Orbitárias/radioterapia , Biópsia , Pré-Escolar , Seguimentos , Humanos , Imageamento por Ressonância Magnética , Masculino , Tumores Neuroectodérmicos Primitivos Periféricos/diagnóstico , Tumores Neuroectodérmicos Primitivos Periféricos/tratamento farmacológico , Neoplasias Orbitárias/diagnóstico , Neoplasias Orbitárias/tratamento farmacológico , Radioterapia Adjuvante , Tomografia Computadorizada por Raios XRESUMO
In the face of increasing public opposition to patents claiming property in gene sequences, is it right to deny the validity of patent applications that seem to have firm, if somewhat hypothetical, scientific basis? In this article we review the recent state of the law in Europe as it applies to gene patents in order to determine whether there is any hope for the modern heirs of Galilean innovation.