Assuntos
Ácido Homovanílico/líquido cefalorraquidiano , Doença de Huntington/líquido cefalorraquidiano , Ácido Hidroxi-Indolacético/líquido cefalorraquidiano , Lítio/uso terapêutico , Fenilacetatos/líquido cefalorraquidiano , Probenecid/farmacologia , Carbonatos/uso terapêutico , Humanos , Doença de Huntington/tratamento farmacológicoRESUMO
HVA and 5-HIAA levels have been assayed in the rat brain at different time intervals after acute or chronic i.p. administration of tetrahydropapaveroline (THP), 8 and 60 mg/kg. In addition, the influence of THP pretreatment on the L-dopa-induced HVA increase in the rat brain as well as the PCPA-induced 5-HIAA decrease have been studied. The results support the possibility that THP may displace brain monoamines in vivo. This property of THP may be related to certain side effects of L-dopa long-term therapy in parkinsonism.
Assuntos
Encéfalo/metabolismo , Dopamina/metabolismo , Isoquinolinas/farmacologia , Papaverina/análogos & derivados , Serotonina/metabolismo , Animais , Fenclonina/farmacologia , Ácido Homovanílico/metabolismo , Levodopa/farmacologia , Masculino , Papaverina/administração & dosagem , Papaverina/farmacologia , RatosRESUMO
A case of Kleine-Levin syndrome with true hypersomnia and a case of sub-wakefulness are described. In both patients lumbar cerebrospinal fluid homovanillic acid, 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylethylene glycol levels have been assayed during episodes of hypersomnia and normal sleep-waking cycles. Besides an increased 5-hydroxytryptamine turnover, mainly an increased dopamine turnover has been detected in both kinds of hypersomnia, and this finding was more remarkable in the case with sub-wakefulness. The probable role of dopamine in abnormalities in the sleep-waking cycle is discussed on the basis of results in experimental animal hypersomnias.
Assuntos
3-Metoxi-4-Hidroxifeniletanol/líquido cefalorraquidiano , Catecóis/líquido cefalorraquidiano , Distúrbios do Sono por Sonolência Excessiva/líquido cefalorraquidiano , Ácido Homovanílico/líquido cefalorraquidiano , Fenilacetatos/líquido cefalorraquidiano , Transtornos do Sono-Vigília/líquido cefalorraquidiano , Adolescente , Criança , Dopamina/líquido cefalorraquidiano , Transtornos da Alimentação e da Ingestão de Alimentos/líquido cefalorraquidiano , Feminino , Humanos , Ácido Hidroxi-Indolacético/líquido cefalorraquidiano , Masculino , Probenecid , Serotonina/líquido cefalorraquidiano , SíndromeRESUMO
Lumbar CSF HVA and 5-HIAA levels were assayed in 3 groups each of 10 subjects, which were respectively deprived of sleep for 30 h, deprived of REM sleep and disturbed with several awakenings during SW sleep for two consecutive nights. HVA levels after total sleep (39 +/- 20 ng/ml) or REM (35 +/- 11 ng/ml) deprivation as well as after SW sleep awakenings (32 +/- 26 ng/ml) were not different from controls (42 +/- 14 ng/ml). 5-HIAA levels after REM deprivation (32 +/- 15 ng/ml) appeared increased when compared with controls (21 +/- 7 ng/ml), total sleep-deprived subjects (21 +/- 10 ng/ml) or subjects with SW sleep awakenings (27 +/- 13 ng/ml). Possible increase in 5-HT turnover after REM deprivation and possible 5-HT role in REM sleep regulation in humans are discussed.