Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.

Brumbaugh, Justin; Di Stefano, Bruno; Wang, Xiuye; Borkent, Marti; Forouzmand, Elmira; Clowers, Katie J; Ji, Fei; Schwarz, Benjamin A; Kalocsay, Marian; Elledge, Stephen J; Chen, Yue; Sadreyev, Ruslan I; Gygi, Steven P; Hu, Guang; Shi, Yongsheng; Hochedlinger, Konrad.

Cell ; 172(1-2): 106-120.e21, 2018 01 11.

Artigo em Inglês | MEDLINE | ID: mdl-29249356

2.

Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior.

Naxerova, Kamila; Di Stefano, Bruno; Makofske, Jessica L; Watson, Emma V; de Kort, Marit A; Martin, Timothy D; Dezfulian, Mohammed; Ricken, Dominik; Wooten, Eric C; Kuroda, Mitzi I; Hochedlinger, Konrad; Elledge, Stephen J.

Genes Dev ; 35(21-22): 1527-1547, 2021 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-34711655

3.

Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells.

Yagi, Masaki; Ji, Fei; Charlton, Jocelyn; Cristea, Simona; Messemer, Kathleen; Horwitz, Naftali; Di Stefano, Bruno; Tsopoulidis, Nikolaos; Hoetker, Michael S; Huebner, Aaron J; Bar-Nur, Ori; Almada, Albert E; Yamamoto, Masakazu; Patelunas, Anthony; Goldhamer, David J; Wagers, Amy J; Michor, Franziska; Meissner, Alexander; Sadreyev, Ruslan I; Hochedlinger, Konrad.

Genes Dev ; 35(17-18): 1209-1228, 2021 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-34413137

4.

Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.

Brumbaugh, Justin; Di Stefano, Bruno; Wang, Xiuye; Borkent, Marti; Forouzmand, Elmira; Clowers, Katie J; Ji, Fei; Schwarz, Benjamin A; Kalocsay, Marian; Elledge, Stephen J; Chen, Yue; Sadreyev, Ruslan I; Gygi, Steven P; Hu, Guang; Shi, Yongsheng; Hochedlinger, Konrad.

Cell ; 172(3): 629-631, 2018 01 25.

Artigo em Inglês | MEDLINE | ID: mdl-29373832

5.

Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells.

Choi, Jiho; Huebner, Aaron J; Clement, Kendell; Walsh, Ryan M; Savol, Andrej; Lin, Kaixuan; Gu, Hongcang; Di Stefano, Bruno; Brumbaugh, Justin; Kim, Sang-Yong; Sharif, Jafar; Rose, Christopher M; Mohammad, Arman; Odajima, Junko; Charron, Jean; Shioda, Toshi; Gnirke, Andreas; Gygi, Steven; Koseki, Haruhiko; Sadreyev, Ruslan I; Xiao, Andrew; Meissner, Alexander; Hochedlinger, Konrad.

Nature ; 548(7666): 219-223, 2017 08 10.

Artigo em Inglês | MEDLINE | ID: mdl-28746311

6.

Reprogramming: identifying the mechanisms that safeguard cell identity.

Brumbaugh, Justin; Di Stefano, Bruno; Hochedlinger, Konrad.

Development ; 146(23)2019 12 02.

Artigo em Inglês | MEDLINE | ID: mdl-31792064

7.

Zrf1 is required to establish and maintain neural progenitor identity.

Aloia, Luigi; Di Stefano, Bruno; Sessa, Alessandro; Morey, Lluis; Santanach, Alexandra; Gutierrez, Arantxa; Cozzuto, Luca; Benitah, Salvador Aznar; Graf, Thomas; Broccoli, Vania; Di Croce, Luciano.

Genes Dev ; 28(2): 182-97, 2014 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-24449271

8.

Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells.

Di Stefano, Bruno; Ueda, Mai; Sabri, Shan; Brumbaugh, Justin; Huebner, Aaron J; Sahakyan, Anna; Clement, Kendell; Clowers, Katie J; Erickson, Alison R; Shioda, Keiko; Gygi, Steven P; Gu, Hongcang; Shioda, Toshi; Meissner, Alexander; Takashima, Yasuhiro; Plath, Kathrin; Hochedlinger, Konrad.

Nat Methods ; 15(9): 732-740, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-30127506

9.

C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells.

Di Stefano, Bruno; Sardina, Jose Luis; van Oevelen, Chris; Collombet, Samuel; Kallin, Eric M; Vicent, Guillermo P; Lu, Jun; Thieffry, Denis; Beato, Miguel; Graf, Thomas.

Nature ; 506(7487): 235-9, 2014 Feb 13.

Artigo em Inglês | MEDLINE | ID: mdl-24336202

10.

Logical modeling of lymphoid and myeloid cell specification and transdifferentiation.

Collombet, Samuel; van Oevelen, Chris; Sardina Ortega, Jose Luis; Abou-Jaoudé, Wassim; Di Stefano, Bruno; Thomas-Chollier, Morgane; Graf, Thomas; Thieffry, Denis.

Proc Natl Acad Sci U S A ; 114(23): 5792-5799, 2017 06 06.

Artigo em Inglês | MEDLINE | ID: mdl-28584084

11.

TBR2 antagonizes retinoic acid dependent neuronal differentiation by repressing Zfp423 during corticogenesis.

Massimino, Luca; Flores-Garcia, Lisbeth; Di Stefano, Bruno; Colasante, Gaia; Icoresi-Mazzeo, Cecilia; Zaghi, Mattia; Hamilton, Bruce A; Sessa, Alessandro.

Dev Biol ; 434(2): 231-248, 2018 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-29305158

12.

Cell reprogramming: Brain versus brawn.

Di Stefano, Bruno; Hochedlinger, Konrad.

Nature ; 534(7607): 332-3, 2016 06 16.

Artigo em Inglês | MEDLINE | ID: mdl-27281201

13.

Polycomb complexes in stem cells and embryonic development.

Aloia, Luigi; Di Stefano, Bruno; Di Croce, Luciano.

Development ; 140(12): 2525-34, 2013 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-23715546

14.

Site-specific integration and tailoring of cassette design for sustainable gene transfer.

Lombardo, Angelo; Cesana, Daniela; Genovese, Pietro; Di Stefano, Bruno; Provasi, Elena; Colombo, Daniele F; Neri, Margherita; Magnani, Zulma; Cantore, Alessio; Lo Riso, Pietro; Damo, Martina; Pello, Oscar M; Holmes, Michael C; Gregory, Philip D; Gritti, Angela; Broccoli, Vania; Bonini, Chiara; Naldini, Luigi.

Nat Methods ; 8(10): 861-9, 2011 Aug 21.

Artigo em Inglês | MEDLINE | ID: mdl-21857672

15.

Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing.

Maneix, Laure; Iakova, Polina; Lee, Charles G; Moree, Shannon E; Lu, Xuan; Datar, Gandhar K; Hill, Cedric T; Spooner, Eric; King, Jordon C K; Sykes, David B; Saez, Borja; Di Stefano, Bruno; Chen, Xi; Krause, Daniela S; Sahin, Ergun; Tsai, Francis T F; Goodell, Margaret A; Berk, Bradford C; Scadden, David T; Catic, André.

Nat Cell Biol ; 26(4): 593-603, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38553595

16.

Early Life Reprogramming-Based Treatment Promotes Longevity.

Pessina, Patrizia; Di Stefano, Bruno.

Cell Reprogram ; 25(1): 9-10, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36594927

17.

Chemical reprogramming takes the fast lane.

Park, Emily J; Kodali, Srikanth; Di Stefano, Bruno.

Cell Stem Cell ; 30(4): 335-337, 2023 04 06.

Artigo em Inglês | MEDLINE | ID: mdl-37028396

18.

H3K36 methylation maintains cell identity by regulating opposing lineage programmes.

Hoetker, Michael S; Yagi, Masaki; Di Stefano, Bruno; Langerman, Justin; Cristea, Simona; Wong, Lai Ping; Huebner, Aaron J; Charlton, Jocelyn; Deng, Weixian; Haggerty, Chuck; Sadreyev, Ruslan I; Meissner, Alexander; Michor, Franziska; Plath, Kathrin; Hochedlinger, Konrad.

Nat Cell Biol ; 25(8): 1121-1134, 2023 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-37460697

19.

Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.

Verpelli, Chiara; Dvoretskova, Elena; Vicidomini, Cinzia; Rossi, Francesca; Chiappalone, Michela; Schoen, Michael; Di Stefano, Bruno; Mantegazza, Renato; Broccoli, Vania; Böckers, Tobias M; Dityatev, Alexander; Sala, Carlo.

J Biol Chem ; 286(40): 34839-50, 2011 Oct 07.

Artigo em Inglês | MEDLINE | ID: mdl-21795692

20.

A microRNA-based system for selecting and maintaining the pluripotent state in human induced pluripotent stem cells.

Di Stefano, Bruno; Maffioletti, Sara Martina; Gentner, Bernhard; Ungaro, Federica; Schira, Giulia; Naldini, Luigi; Broccoli, Vania.

Stem Cells ; 29(11): 1684-95, 2011 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-21898693

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Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.

Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior.

Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells.

Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.

Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells.

Reprogramming: identifying the mechanisms that safeguard cell identity.

Zrf1 is required to establish and maintain neural progenitor identity.

Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells.

C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells.

Logical modeling of lymphoid and myeloid cell specification and transdifferentiation.

TBR2 antagonizes retinoic acid dependent neuronal differentiation by repressing Zfp423 during corticogenesis.

Cell reprogramming: Brain versus brawn.

Polycomb complexes in stem cells and embryonic development.

Site-specific integration and tailoring of cassette design for sustainable gene transfer.

Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing.

Early Life Reprogramming-Based Treatment Promotes Longevity.

Chemical reprogramming takes the fast lane.

H3K36 methylation maintains cell identity by regulating opposing lineage programmes.

Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.

A microRNA-based system for selecting and maintaining the pluripotent state in human induced pluripotent stem cells.