Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

An in vitro toolbox to accelerate anti-malarial drug discovery and development.

Charman, Susan A; Andreu, Alice; Barker, Helena; Blundell, Scott; Campbell, Anna; Campbell, Michael; Chen, Gong; Chiu, Francis C K; Crighton, Elly; Katneni, Kasiram; Morizzi, Julia; Patil, Rahul; Pham, Thao; Ryan, Eileen; Saunders, Jessica; Shackleford, David M; White, Karen L; Almond, Lisa; Dickins, Maurice; Smith, Dennis A; Moehrle, Joerg J; Burrows, Jeremy N; Abla, Nada.

Malar J ; 19(1): 1, 2020 Jan 02.

Artigo em Inglês | MEDLINE | ID: mdl-31898492

2.

Development and application of a PBPK modeling strategy to support antimalarial drug development.

Abla, Nada; Howgate, Eleanor; Rowland-Yeo, Karen; Dickins, Maurice; Bergagnini-Kolev, Mackenzie C; Chen, Kuan-Fu; McFeely, Savannah; Bonner, Jennifer J; Santos, Laura G A; Gobeau, Nathalie; Burt, Howard; Barter, Zoe; Jones, Hannah M; Wesche, David; Charman, Susan A; Möhrle, Jörg J; Burrows, Jeremy N; Almond, Lisa M.

CPT Pharmacometrics Syst Pharmacol ; 12(9): 1335-1346, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37587640

3.

The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance.

Fenner, Katherine S; Jones, Hannah M; Ullah, Mohammed; Kempshall, Sarah; Dickins, Maurice; Lai, Yurong; Morgan, Paul; Barton, Hugh A.

Xenobiotica ; 42(1): 28-45, 2012 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-22077101

4.

Case studies addressing human pharmacokinetic uncertainty using a combination of pharmacokinetic simulation and alternative first in human paradigms.

Harrison, Anthony; Gardner, Iain; Hay, Tanya; Dickins, Maurice; Beaumont, Kevin; Phipps, Alex; Purkins, Lynn; Allan, Gill; Christian, Rachelle; Duckworth, Jonathan; Gurrell, Ian; Kempshall, Sarah; Savage, Mark; Seymour, Mark; Simpson, Marie; Taylor, Louise; Turnpenny, Paul.

Xenobiotica ; 42(1): 57-74, 2012 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-21992032

5.

Application of PBPK modelling in drug discovery and development at Pfizer.

Jones, Hannah M; Dickins, Maurice; Youdim, Kuresh; Gosset, James R; Attkins, Neil J; Hay, Tanya L; Gurrell, Ian K; Logan, Y Raj; Bungay, Peter J; Jones, Barry C; Gardner, Iain B.

Xenobiotica ; 42(1): 94-106, 2012 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-22035569

6.

Effects of the moderate CYP3A4 inhibitor, fluconazole, on the pharmacokinetics of fesoterodine in healthy subjects.

Malhotra, Bimal; Dickins, Maurice; Alvey, Christine; Jumadilova, Zhanna; Li, Xiaoxi; Duczynski, Gregory; Gandelman, Kuan.

Br J Clin Pharmacol ; 72(2): 263-9, 2011 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-21545485

7.

Comparison of different algorithms for predicting clinical drug-drug interactions, based on the use of CYP3A4 in vitro data: predictions of compounds as precipitants of interaction.

Fahmi, Odette A; Hurst, Susan; Plowchalk, David; Cook, Jack; Guo, Feng; Youdim, Kuresh; Dickins, Maurice; Phipps, Alex; Darekar, Amanda; Hyland, Ruth; Obach, R Scott.

Drug Metab Dispos ; 37(8): 1658-66, 2009 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-19406954

8.

Maraviroc: in vitro assessment of drug-drug interaction potential.

Hyland, Ruth; Dickins, Maurice; Collins, Claire; Jones, Hannah; Jones, Barry.

Br J Clin Pharmacol ; 66(4): 498-507, 2008 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-18647303

9.

Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction.

Youdim, Kuresh A; Zayed, Aref; Dickins, Maurice; Phipps, Alex; Griffiths, Michelle; Darekar, Amanda; Hyland, Ruth; Fahmi, Odette; Hurst, Susan; Plowchalk, David R; Cook, Jack; Guo, Feng; Obach, R Scott.

Br J Clin Pharmacol ; 65(5): 680-92, 2008 May.

Artigo em Inglês | MEDLINE | ID: mdl-18279465

10.

Risk-Benefit Assessment of Ethinylestradiol Using a Physiologically Based Pharmacokinetic Modeling Approach.

Ezuruike, Udoamaka; Humphries, Helen; Dickins, Maurice; Neuhoff, Sibylle; Gardner, Iain; Rowland Yeo, Karen.

Clin Pharmacol Ther ; 104(6): 1229-1239, 2018 12.

Artigo em Inglês | MEDLINE | ID: mdl-29637542

11.

Substrate SARs in human P450s.

Lewis, David F V; Dickins, Maurice.

Drug Discov Today ; 7(17): 918-25, 2002 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-12546935

12.

Compound lipophilicity for substrate binding to human P450s in drug metabolism.

Lewis, David F V; Jacobs, Miriam N; Dickins, Maurice.

Drug Discov Today ; 9(12): 530-7, 2004 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-15183161

13.

Induction of cytochromes P450.

Dickins, Maurice.

Curr Top Med Chem ; 4(16): 1745-66, 2004.

Artigo em Inglês | MEDLINE | ID: mdl-15579106

14.

Substrates of human cytochromes P450 from families CYP1 and CYP2: analysis of enzyme selectivity and metabolism.

Lewis, David F V; Lake, Brian G; Dickins, Maurice.

Drug Metabol Drug Interact ; 20(3): 111-42, 2004.

Artigo em Inglês | MEDLINE | ID: mdl-15508429

15.

Investigation of enzyme selectivity in the human CYP2C subfamily: homology modelling of CYP2C8, CYP2C9 and CYP2C19 from the CYP2C5 crystallographic template.

Lewis, David F V; Dickins, Maurice; Lake, Brian G; Goldfarb, Peter S.

Drug Metabol Drug Interact ; 19(4): 257-85, 2003.

Artigo em Inglês | MEDLINE | ID: mdl-14768974

16.

Molecular modelling of CYP2B6 based on homology with the CYP2C5 crystal structure: analysis of enzyme-substrate interactions.

Lewis, David F V; Lake, Brian G; Dickins, Maurice; Goldfarb, Peter S.

Drug Metabol Drug Interact ; 19(2): 115-35, 2002.

Artigo em Inglês | MEDLINE | ID: mdl-12751910

17.

A molecular model of CYP2D6 constructed by homology with the CYP2C5 crystallographic template: investigation of enzyme-substrate interactions.

Lewis, David F V; Dickins, Maurice; Lake, Brian G; Goldfarb, Peter S.

Drug Metabol Drug Interact ; 19(3): 189-210, 2003.

Artigo em Inglês | MEDLINE | ID: mdl-14682610

18.

Simulation of human intravenous and oral pharmacokinetics of 21 diverse compounds using physiologically based pharmacokinetic modelling.

Jones, Hannah M; Gardner, Iain B; Collard, Wendy T; Stanley, Phil J; Oxley, Penny; Hosea, Natilie A; Plowchalk, David; Gernhardt, Steve; Lin, Jing; Dickins, Maurice; Rahavendran, S Ravi; Jones, Barry C; Watson, Kenny J; Pertinez, Henry; Kumar, Vikas; Cole, Susan.

Clin Pharmacokinet ; 50(5): 331-47, 2011 May.

Artigo em Inglês | MEDLINE | ID: mdl-21456633

19.

An evaluation of ondansetron binding interactions with human cytochrome P450 enzymes CYP3A4 and CYP2D6.

Lewis, David F V; Ito, Yuko; Eddershaw, Peter J; Dickins, Maurice; Goldfarb, Peter S.

Drug Metab Lett ; 4(1): 25-30, 2010 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-20201779

20.

The importance of predictive ADME simulation.

Dickins, Maurice; Modi, Sandeep.

Drug Discov Today ; 7(14): 755-6, 2002 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-12547029

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