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1.
Exp Eye Res ; 243: 109900, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38636803

RESUMO

A pterygium is a wedge-shaped fibrovascular growth of the conjunctiva membrane that extends onto the cornea, which is the outer layer of the eye. It is also known as surfer's eye. Growth of a pterygium can also occur on the either side of the eye, attaching firmly to the sclera. Pterygia are one of the world's most common ocular diseases. However, the pathogenesis remains unsolved to date. As the pathogenesis of pterygium is closely related to finding the ideal treatment, a clear understanding of the pathogenesis will lead to better treatment and lower the recurrence rate, which is notably high and more difficult to treat than a primary pterygium. Massive studies have recently been conducted to determine the exact causes and mechanism of pterygia. We evaluated the pathogenetic factors ultraviolet radiation, viral infection, tumor suppressor genes p53, growth factors, oxidative stress, apoptosis and neuropeptides in the progression of the disease. The heightened expression of TRPV1 suggests its potential contribution in the occurrence of pterygium, promoting its inflammation and modulating sensory responses in ocular tissues. Subsequently, the developmental mechanism of pterygium, along with its correlation with dry eye disease is proposed to facilitate the identification of pathogenetic factors for pterygia, contributing to the advancement of understanding in this area and may lead to improved surgical outcomes.


Assuntos
Pterígio , Pterígio/etiologia , Pterígio/metabolismo , Humanos , Fatores de Risco , Estresse Oxidativo , Raios Ultravioleta/efeitos adversos , Apoptose , Túnica Conjuntiva/patologia
2.
Sci Rep ; 14(1): 23734, 2024 10 10.
Artigo em Inglês | MEDLINE | ID: mdl-39390058

RESUMO

Calcaneal body fractures are often associated with varying degrees of shortening deformities. Restoring calcaneal length is crucial for the functional prognosis of the foot. Through finite element analysis, this study compared the biomechanical effects of multiple fixation schemes for calcaneal fractures. We delineated and assembled the finite element model of the Sanders type II calcaneal fracture and four internal fixation simulations (namely distraction screw, lag screw, frame locking plate, and T-shaped locking plate). Different axial forces (350, 700, and 1400 N) were then applied to simulate various postures. We then compared the inner and outer shortening distances (D1 and D2, respectively), equivalent von Mises stress, and maximum von Mises stress of the calcaneus. In the individual model, with an increase in the pressure, D1, D2, and the maximum von Mises stress gradually increased. At 1400 N, D1 and D2 for the internal fixation schemes were as follows: distraction screw (0.03 mm, 0.1 mm) < T-shaped locking plate (0.45 mm, 0.26 mm) < frame locking plate (0.50 mm, 0.26 mm) < lag screw (0.66 mm, 0.64 mm). The maximum von Mises stress values for the internal fixation methods were as follows: lag screw (491.0 MPa) < distraction screw (663.1 MPa) < frame locking plate (772.7 MPa) < T-shaped locking plate (931.8 MPa). In patients with calcaneal body fractures, the distraction screw is a potential therapeutic option for resisting calcaneal shortening.


Assuntos
Calcâneo , Análise de Elementos Finitos , Fixação Interna de Fraturas , Fraturas Ósseas , Fixação Interna de Fraturas/métodos , Humanos , Calcâneo/cirurgia , Calcâneo/lesões , Fraturas Ósseas/cirurgia , Fenômenos Biomecânicos , Parafusos Ósseos , Estresse Mecânico , Placas Ósseas
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