Detalhe da pesquisa
1.
The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.
Mol Cell
; 81(12): 2520-2532.e16, 2021 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33930333
2.
Reversible Control of RNA Splicing by Photoswitchable Small Molecules.
J Am Chem Soc
; 145(23): 12783-12792, 2023 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37276581
3.
Expanding the Accessible Chemical Space of SIRT2 Inhibitors through Exploration of Binding Pocket Dynamics.
J Chem Inf Model
; 62(10): 2571-2585, 2022 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35467856
4.
Synthesis, in silico, and in vitro studies of novel dopamine D2 and D3 receptor ligands.
Arch Pharm (Weinheim)
; 354(6): e2000486, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33615541
5.
Synthesis and Biological Activity of a Cytostatic Inhibitor of MLLr Leukemia Targeting the DOT1L Protein.
Molecules
; 26(17)2021 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34500733
6.
Modulating Protein-Protein Interactions with Visible-Light-Responsive Peptide Backbone Photoswitches.
Chembiochem
; 20(11): 1417-1429, 2019 06 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30675988
7.
SIRT2i_Predictor: A Machine Learning-Based Tool to Facilitate the Discovery of Novel SIRT2 Inhibitors.
Pharmaceuticals (Basel)
; 16(1)2023 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36678624
8.
Correlating Basal Gene Expression across Chemical Sensitivity Data to Screen for Novel Synergistic Interactors of HDAC Inhibitors in Pancreatic Carcinoma.
Pharmaceuticals (Basel)
; 16(2)2023 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37259439
9.
Targeting Histone Deacetylases 6 in Dual-Target Therapy of Cancer.
Pharmaceutics
; 15(11)2023 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38004560
10.
Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention.
Pharmaceutics
; 14(1)2022 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35057104
11.
Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies.
Future Med Chem
; 14(8): 557-570, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35332778
12.
Discovery of 1-Benzhydryl-Piperazine-Based HDAC Inhibitors with Anti-Breast Cancer Activity: Synthesis, Molecular Modeling, In Vitro and In Vivo Biological Evaluation.
Pharmaceutics
; 14(12)2022 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36559094
13.
Bistable Photoswitch Allows in Vivo Control of Hematopoiesis.
ACS Cent Sci
; 8(1): 57-66, 2022 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35106373
14.
Fragment-Based Drug Design of Selective HDAC6 Inhibitors.
Methods Mol Biol
; 2266: 155-170, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33759126
15.
An Integrative in silico Drug Repurposing Approach for Identification of Potential Inhibitors of SARS-CoV-2 Main Protease.
Mol Inform
; 40(5): e2000187, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33787066
16.
Structure-based design of selective histone deacetylase 6 zinc binding groups.
J Biomol Struct Dyn
; 38(11): 3166-3177, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-31382868
17.
In silico Methods for Design of Kinase Inhibitors as Anticancer Drugs.
Front Chem
; 7: 873, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31970149