Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Concentration-QT modelling of the novel DHFR inhibitor P218 in healthy male volunteers.

Täubel, JÓ§rg; Lorch, Ulrike; Ferber, Georg; Spencer, Christopher S; Freier, Anne; Coates, Simon; El Gaaloul, Myriam; Donini, Cristina; Chughlay, Mohamed Farouk; Chalon, Stephan.

Br J Clin Pharmacol ; 88(1): 128-137, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34075612

2.

Malaria - Epidemiology, Treatment, and Prevention.

Baden, Lindsey; Catteruccia, Flaminia; Diabaté, Abdoulaye; Donini, Cristina; Nosten, François; O'Neill, Scott; Osier, Faith; Phyo, Aung Pyae; White, Nicholas.

N Engl J Med ; 388(5): e9, 2023 02 02.

Artigo em Inglês | MEDLINE | ID: mdl-36724327

3.

A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048.

McCarthy, James S; Donini, Cristina; Chalon, Stephan; Woodford, John; Marquart, Louise; Collins, Katharine A; Rozenberg, Felix D; Fidock, David A; Cherkaoui-Rbati, Mohammed H; Gobeau, Nathalie; Möhrle, Jörg J.

Clin Infect Dis ; 71(10): e657-e664, 2020 12 17.

Artigo em Inglês | MEDLINE | ID: mdl-32239164

4.

Safety, Tolerability, Pharmacokinetics, and Antimalarial Activity of the Novel Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048 in Healthy Volunteers.

Sinxadi, Phumla; Donini, Cristina; Johnstone, Hilary; Langdon, Grant; Wiesner, Lubbe; Allen, Elizabeth; Duparc, Stephan; Chalon, Stephan; McCarthy, James S; Lorch, Ulrike; Chibale, Kelly; Möhrle, Jörg; Barnes, Karen I.

Antimicrob Agents Chemother ; 64(4)2020 03 24.

Artigo em Inglês | MEDLINE | ID: mdl-31932368

5.

Monoclonal Antibodies for Malaria.

Wells, Timothy; Donini, Cristina.

N Engl J Med ; 387(5): 462-465, 2022 08 04.

Artigo em Inglês | MEDLINE | ID: mdl-35921457

6.

First-in-human clinical trial to assess the safety, tolerability and pharmacokinetics of P218, a novel candidate for malaria chemoprotection.

Chughlay, M Farouk; Rossignol, Emilie; Donini, Cristina; El Gaaloul, Myriam; Lorch, Ulrike; Coates, Simon; Langdon, Grant; Hammond, Tim; Möhrle, Jörg; Chalon, Stephan.

Br J Clin Pharmacol ; 86(6): 1113-1124, 2020 06.

Artigo em Inglês | MEDLINE | ID: mdl-31925817

7.

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.

Brunschwig, Christel; Lawrence, Nina; Taylor, Dale; Abay, Efrem; Njoroge, Mathew; Basarab, Gregory S; Le Manach, Claire; Paquet, Tanya; Cabrera, Diego Gonzàlez; Nchinda, Aloysius T; de Kock, Carmen; Wiesner, Lubbe; Denti, Paolo; Waterson, David; Blasco, Benjamin; Leroy, Didier; Witty, Michael J; Donini, Cristina; Duffy, James; Wittlin, Sergio; White, Karen L; Charman, Susan A; Jiménez-Díaz, Maria Belén; Angulo-Barturen, Iñigo; Herreros, Esperanza; Gamo, Francisco Javier; Rochford, Rosemary; Mancama, Dalu; Coetzer, Theresa L; van der Watt, Mariëtte E; Reader, Janette; Birkholtz, Lyn-Marie; Marsh, Kennan C; Solapure, Suresh M; Burke, John E; McPhail, Jacob A; Vanaerschot, Manu; Fidock, David A; Fish, Paul V; Siegl, Peter; Smith, Dennis A; Wirjanata, Grennady; Noviyanti, Rintis; Price, Ric N; Marfurt, Jutta; Silue, Kigbafori D; Street, Leslie J; Chibale, Kelly.

Antimicrob Agents Chemother ; 62(9)2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-29941635

8.

Carbon-14 radiolabeling and tissue distribution evaluation of MMV390048.

Sonopo, Molahlehi S; Pillay, Adushan; Chibale, Kelly; Marjanovic-Painter, Biljana; Donini, Cristina; Zeevaart, Jan R.

J Labelled Comp Radiopharm ; 59(14): 680-688, 2016 12.

Artigo em Inglês | MEDLINE | ID: mdl-27646069

9.

ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.

Miley, Galen P; Pou, Sovitj; Winter, Rolf; Nilsen, Aaron; Li, Yuexin; Kelly, Jane X; Stickles, Allison M; Mather, Michael W; Forquer, Isaac P; Pershing, April M; White, Karen; Shackleford, David; Saunders, Jessica; Chen, Gong; Ting, Li-Min; Kim, Kami; Zakharov, Lev N; Donini, Cristina; Burrows, Jeremy N; Vaidya, Akhil B; Charman, Susan A; Riscoe, Michael K.

Antimicrob Agents Chemother ; 59(9): 5555-60, 2015 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-26124159

10.

Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".

Brunschwig, Christel; Lawrence, Nina; Taylor, Dale; Abay, Efrem; Njoroge, Mathew; Basarab, Gregory S; Le Manach, Claire; Paquet, Tanya; Gonzàlez Cabrera, Diego; Nchinda, Aloysius T; de Kock, Carmen; Wiesner, Lubbe; Denti, Paolo; Waterson, David; Blasco, Benjamin; Leroy, Didier; Witty, Michael J; Donini, Cristina; Duffy, James; Wittlin, Sergio; White, Karen L; Charman, Susan A; Jiménez-Díaz, Maria Belén; Angulo-Barturen, Iñigo; Herreros, Esperanza; Gamo, Francisco Javier; Rochford, Rosemary; Mancama, Dalu; Coetzer, Theresa L; van der Watt, Mariëtte E; Reader, Janette; Birkholtz, Lyn-Marie; Marsh, Kennan C; Solapure, Suresh M; Burke, John E; McPhail, Jacob A; Vanaerschot, Manu; Fidock, David A; Fish, Paul V; Siegl, Peter; Smith, Dennis A; Wirjanata, Grennady; Noviyanti, Rintis; Price, Ric N; Marfurt, Jutta; Silue, Kigbafori D; Street, Leslie J; Chibale, Kelly.

Antimicrob Agents Chemother ; 62(11)2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30355750

11.

Efficacy, Safety, Tolerability, and Pharmacokinetics of MMV390048 in Acute Uncomplicated Malaria.

Mohammed, Rezika; Asres, Mezgebu Silamsaw; Gudina, Esayas Kebede; Adissu, Wondimagegn; Johnstone, Hilary; Marrast, Anne Claire; Donini, Cristina; Duparc, Stephan; Yilma, Daniel.

Am J Trop Med Hyg ; 108(1): 81-84, 2023 01 11.

Artigo em Inglês | MEDLINE | ID: mdl-36509063

12.

Malarial PI4K inhibitor induced diaphragmatic hernias in rat: Potential link with mammalian kinase inhibition.

Demarta-Gatsi, Claudia; Donini, Cristina; Duffy, James; Sadler, Claire; Stewart, Jane; Barber, Jane A; Tornesi, Belen.

Birth Defects Res ; 114(10): 487-498, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35416431

13.

Chemoprotective Antimalarial Activity of P218 against Plasmodium falciparum: A Randomized, Placebo-Controlled Volunteer Infection Study.

Chughlay, Mohamed Farouk; El Gaaloul, Myriam; Donini, Cristina; Campo, Brice; Berghmans, Pieter-Jan; Lucardie, Alexander; Marx, Michael W; Cherkaoui-Rbati, Mohammed H; Langdon, Grant; Angulo-Barturen, Iñigo; Viera, Sara; Rosanas-Urgell, Anna; Van Geertruyden, Jean-Pierre; Chalon, Stephan.

Am J Trop Med Hyg ; 104(4): 1348-1358, 2021 02 08.

Artigo em Inglês | MEDLINE | ID: mdl-33556040

14.

Discovery of a novel series of potent S1P1 agonists.

Crosignani, Stefano; Bombrun, Agnes; Covini, David; Maio, Maurizio; Marin, Delphine; Quattropani, Anna; Swinnen, Dominique; Simpson, Don; Sauer, Wolfgang; Françon, Bernard; Martin, Thierry; Cambet, Yves; Nichols, Anthony; Martinou, Isabelle; Burgat-Charvillon, Fabienne; Rivron, Delphine; Donini, Cristina; Schott, Olivier; Eligert, Valerie; Novo-Perez, Laurence; Vitte, Pierre-Alain; Arrighi, Jean-François.

Bioorg Med Chem Lett ; 20(5): 1516-9, 2010 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-20149651

15.

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.

Paquet, Tanya; Le Manach, Claire; Cabrera, Diego González; Younis, Yassir; Henrich, Philipp P; Abraham, Tara S; Lee, Marcus C S; Basak, Rajshekhar; Ghidelli-Disse, Sonja; Lafuente-Monasterio, María José; Bantscheff, Marcus; Ruecker, Andrea; Blagborough, Andrew M; Zakutansky, Sara E; Zeeman, Anne-Marie; White, Karen L; Shackleford, David M; Mannila, Janne; Morizzi, Julia; Scheurer, Christian; Angulo-Barturen, Iñigo; Martínez, María Santos; Ferrer, Santiago; Sanz, Laura María; Gamo, Francisco Javier; Reader, Janette; Botha, Mariette; Dechering, Koen J; Sauerwein, Robert W; Tungtaeng, Anchalee; Vanachayangkul, Pattaraporn; Lim, Chek Shik; Burrows, Jeremy; Witty, Michael J; Marsh, Kennan C; Bodenreider, Christophe; Rochford, Rosemary; Solapure, Suresh M; Jiménez-Díaz, María Belén; Wittlin, Sergio; Charman, Susan A; Donini, Cristina; Campo, Brice; Birkholtz, Lyn-Marie; Hanson, Kirsten K; Drewes, Gerard; Kocken, Clemens H M; Delves, Michael J; Leroy, Didier; Fidock, David A.

Sci Transl Med ; 9(387)2017 04 26.

Artigo em Inglês | MEDLINE | ID: mdl-28446690

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