Detalhe da pesquisa
1.
The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening.
Bioorg Med Chem Lett
; 102: 129675, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38417632
2.
Expanding the DNA-encoded library toolbox: identifying small molecules targeting RNA.
Nucleic Acids Res
; 50(12): e67, 2022 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35288754
3.
Structural and Functional Insights into PpgL, a Metal-Independent ß-Propeller Gluconolactonase That Contributes to Pseudomonas aeruginosa Virulence.
Infect Immun
; 87(4)2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30642898
4.
Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases.
Bioorg Med Chem
; 21(1): 102-13, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23211969
5.
Optimization of PROTAC Ternary Complex Using DNA Encoded Library Approach.
ACS Chem Biol
; 18(1): 25-33, 2023 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36606710
6.
Amino acid-derived 1,2-benzisothiazolinone derivatives as novel small-molecule antifungal inhibitors: identification of potential genetic targets.
Antimicrob Agents Chemother
; 56(9): 4630-9, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22687516
7.
Inhibition of noroviruses by piperazine derivatives.
Bioorg Med Chem Lett
; 22(1): 377-9, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22119464
8.
Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives.
Bioorg Med Chem
; 20(3): 1213-21, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22249124
9.
Potent norovirus inhibitors based on the acyclic sulfamide scaffold.
Bioorg Med Chem
; 20(6): 2111-8, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22356738
10.
Dual function inhibitors of relevance to chronic obstructive pulmonary disease.
Bioorg Med Chem Lett
; 21(10): 3177-80, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21511470
11.
Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives.
Bioorg Med Chem
; 19(19): 5782-7, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21903403
12.
Design and synthesis of inhibitors of noroviruses by scaffold hopping.
Bioorg Med Chem
; 19(19): 5749-55, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21893416
13.
Potent inhibition of Norwalk virus by cyclic sulfamide derivatives.
Bioorg Med Chem
; 19(20): 5975-83, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21925886
14.
A Novel Scalarized Scaffold Hopping Algorithm with Graph-Based Variational Autoencoder for Discovery of JAK1 Inhibitors.
ACS Omega
; 6(35): 22945-22954, 2021 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34514265
15.
Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase.
Bioorg Med Chem
; 18(18): 6646-50, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20728366
16.
Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3.
Bioorg Med Chem
; 18(3): 1093-102, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20061159
17.
Design, synthesis, and in vitro evaluation of potential West Nile virus protease inhibitors based on the 1-oxo-1,2,3,4-tetrahydroisoquinoline and 1-oxo-1,2-dihydroisoquinoline scaffolds.
J Comb Chem
; 12(6): 836-43, 2010 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20882963
18.
Exploring the Lower Limit of Individual DNA-Encoded Library Molecules in Selection.
SLAS Discov
; 25(5): 523-529, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-31858872
19.
Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
ACS Med Chem Lett
; 11(6): 1175-1184, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32550998
20.
Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S' subsite binding.
Bioorg Med Chem
; 17(10): 3536-42, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19394830