1.
J Org Chem
; 64(3): 826-831, 1999 Feb 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11674153
RESUMO
The total synthesis of the macrocyclic hexapeptide bistratamide D is reported. The synthetic strategy involved assembly of enantiomerically pure oxazole, thiazole, and oxazoline segments derived from amino acids. Macrocyclization of the hexapeptidic aminooxazoline-oxazole-thiazole carboxylic acid fragment was accomplished by activation with O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HATU).
2.
Org Lett
; 12(15): 3422-5, 2010 Aug 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20670007
RESUMO
An efficient enantioselective total synthesis of the potent antibiotic GSK966587 was accomplished. Highlights of the synthesis include two innovative Heck reactions, a highly selective zincate base directed ortho-metalation, Sharpless asymmetric epoxidation, and a fully convergent final step fragment coupling.