RESUMO
OBJECTIVE: Driving is a critical topic to counsel among patients with epileptic seizures (ES) and psychogenic nonepileptic seizures (PNES), with significant legal and public health implications. This prospective cohort study examined the frequency of ES and PNES in a single institution's Epilepsy Monitoring Unit (EMU) and assessed driving-related issues between each group. METHODS: Adult patients from the Mayo Clinic Arizona Epilepsy Monitoring Unit (EMU) were given comprehensive surveys addressing driving history. Descriptive analysis and statistics were used to summarize differences between patients with ES and PNES. Differences between patients with epilepsy and PNES were determined by Pearson chi-square. RESULTS: Nearly half (nâ¯=â¯75/163) of all patients admitted to the EMU were diagnosed with PNES. Although the PNES group had a statistically significant higher frequency of events (pâ¯=â¯0.01), 87.7% of these patients reported compliance with the driving law recommendations, suggesting a trend that patients who have been counseled regarding fitness-to-drive are likely to follow the recommendation. One-third of patients with PNES reported an event while operating a motor vehicle and 8% (nâ¯=â¯2/25) resulted in a motor vehicle collision severe enough to require hospitalization. In contrast to those with ES, 25% of patients reported a typical event while driving and 25% (nâ¯=â¯2/8) of those resulted in a collision requiring hospitalization. The incidence of habitual events while driving is higher in the population with PNES (nâ¯=â¯25) when compared to those with ES (nâ¯=â¯8); however, it appears that patients with PNES were less likely to become involved in an accident resulting in seriously bodily injury than in ES. CONCLUSIONS: Compared to patients with PNES, patients with ES have less frequent events but more severe collisions. This study reinforces the need for diligent driving counseling to help prevent driving-related injuries in patients with PNES and ES.
Assuntos
Epilepsia , Convulsões Psicogênicas não Epilépticas , Adulto , Eletroencefalografia/métodos , Epilepsia/complicações , Epilepsia/diagnóstico , Epilepsia/epidemiologia , Humanos , Estudos Prospectivos , Convulsões/diagnóstico , Convulsões/epidemiologia , Convulsões/psicologiaRESUMO
BACKGROUND: The diagnosis of epilepsy is at times elusive for both neurologists and nonneurologists, resulting in delays in diagnosis and therapy. The development of screening methods has been identified as a priority in response to this diagnostic and therapeutic gap. EpiFinder is a novel clinical decision support tool designed to enhance the process of information gathering and integration of patient/proxy respondent data. It is designed specifically to take key terms from a patient's history and incorporate them into a heuristic algorithm that dynamically produces differential diagnoses of epilepsy syndromes. OBJECTIVE: The objective of this study was to test the usability and diagnostic accuracy of the clinical decision support application EpiFinder in an adult population. METHODS: Fifty-seven patients were prospectively identified upon admission to the Epilepsy Monitoring Unit (EMU) for episode classification from January through June of 2017. Based on semiologic input, the application generates a list of epilepsy syndromes. The EpiFinder-generated diagnosis for each subject was compared to the final diagnosis obtained via continuous video electroencephalogram (cVEEG) monitoring. RESULTS: Fifty-three patients had habitual events recorded during their EMU stay. A diagnosis of epilepsy was confirmed (with cVEEG monitoring) in 26 patients while 27 patients were found to have a diagnosis other than epilepsy. The algorithm appropriately predicted differentiation between the presence of an epilepsy syndrome and an alternative diagnosis with 86.8% (46/53 participants) accuracy. EpiFinder correctly identified the presence of epilepsy with a sensitivity of 86.4% (95% confidence interval [CI]: 65.0-97.1) and specificity of 85.1% (95% CI: 70.2-96.4). CONCLUSION: The initial testing of the EpiFinder algorithm suggests possible utility in differentiating between an epilepsy syndrome and an alternative diagnosis in adult patients.
Assuntos
Algoritmos , Sistemas de Apoio a Decisões Clínicas/instrumentação , Epilepsia/diagnóstico , Adulto , Diagnóstico Diferencial , Eletroencefalografia/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Monitorização Fisiológica/métodos , Estudos Prospectivos , Sensibilidade e EspecificidadeRESUMO
Psychological assessment measures are frequently used to evaluate patients in epilepsy monitoring units. One goal of that assessment is to contribute information that may help with differential diagnosis between epilepsy and psychogenic nonepileptic seizures (PNES). The Minnesota Multiphasic Personality Inventory-2 Restructured Form (MMPI-2-RF) is one such measure. Del Bene et al. (2017) recently published an analysis that was the first to compare MMPI-2-RF scale elevations between diagnostic groups stratified by sex. The purpose of the present study was to replicate that analysis in a larger sample. Similar to previous work, we found that both men and women with PNES were more likely than men and women with epilepsy to report high levels of somatic complaints (2 to 5 times greater odds of somatic symptom reporting) and a variety of types of complaints. Mood disturbance scales were not significantly elevated in our PNES sample. Results contribute to the small body of research on sex differences in patients with PNES and suggest that somatization is a key characterization across sexes.
Assuntos
Epilepsia/diagnóstico , MMPI , Convulsões/diagnóstico , Adulto , Diagnóstico Diferencial , Epilepsia/psicologia , Feminino , Unidades Hospitalares , Humanos , Masculino , Pessoa de Meia-Idade , Convulsões/psicologia , Fatores SexuaisRESUMO
BACKGROUND: Antiepileptic drugs (AED) are often considered first line for monotherapy in treatment of patients with migraines, and also those with comorbid migraine and epilepsy. Topiramate, a newer generation AED, has broad mechanism of action and evidence of benefit in patients with either episodic or chronic migraine along with epilepsy, both generalized and focal. METHODS: Our goal is to review the relevant mechanisms of action along with any supportive evidence published to date on the use of topiramate (TPM) in patients with both migraine headache and epilepsy. CONCLUSIONS: There has been very little published to date on the use of TPM in patients diagnosed with both disorders. Despite this, TPM has been adopted as first line therapy in this patient population. Future studies investigating the effectiveness of this treatment strategy are warranted in order to determine the most effective use of this medication in patients diagnosed with migraine headaches and epilepsy.
Assuntos
Epilepsia/tratamento farmacológico , Frutose/análogos & derivados , Transtornos de Enxaqueca/prevenção & controle , Fármacos Neuroprotetores/uso terapêutico , Bases de Dados Bibliográficas/estatística & dados numéricos , Epilepsia/complicações , Feminino , Frutose/uso terapêutico , Humanos , Masculino , Transtornos de Enxaqueca/complicações , TopiramatoRESUMO
Falls are one of the most common adverse events occurring in the epilepsy monitoring unit (EMU) and can result in significant injury. Protocols and procedures to reduce falls vary significantly between institutions as it is not yet known what interventions are effective in the EMU setting. This study retrospectively examined the frequency of falls and the impact of serial changes in fall prevention strategies utilized in the EMU between 2001 and 2014 at a single institution. Overall fall rate was 2.81 per 1000 patient days and varied annually from 0 to 9.02 per 1000 patient days. Both seizures and psychogenic nonepileptic events occurring in the bathroom were more likely to result in falls compared with events occurring elsewhere in the room. With initiation of increased patient education, hourly nurse rounding, nocturnal bed alarms, having two persons assisting for high fall risk patients when out of bed, and immediate postfall team review between 2001 and 2013, there was a trend of decreasing fall frequency; however, no specific intervention could be identified as having a particular high impact. In late 2013, a ceiling lift system extending into the bathroom was put in place for use in all EMU patients when out of bed. In the subsequent 15 months, there have been zero falls. The results reinforce both the need for diligent safety standards to prevent falls in the EMU as well as the challenges in identifying the most effective practices to achieve this goal.
Assuntos
Acidentes por Quedas/prevenção & controle , Acidentes por Quedas/estatística & dados numéricos , Epilepsia/diagnóstico , Segurança do Paciente , Adulto , Idoso , Eletroencefalografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Monitorização Fisiológica , Estudos Retrospectivos , Convulsões , Gravação em VídeoRESUMO
It is clear that many individuals with psychogenic nonepileptic seizures (PNESs) often present with poorer quality of life compared with those with epileptic seizures (ESs). However, the mechanisms linking seizure diagnosis to quality-of-life outcomes are much less clear. Alexithymia and somatization are emotional markers of psychological functioning that may explain these differences in quality of life. In the current study, patients from an epilepsy monitoring unit with vEEG-confirmed diagnosis of PNESs or ESs were compared on measures of alexithymia, somatization, quality of life, and a variety of demographic and medical variables. Two models using alexithymia and somatization individually as mediators of the relations between diagnosis and quality of life were tested. Results indicated that patients with PNESs had significantly poorer quality of life compared with those with ESs. Alexithymia was associated with poor quality of life in both groups but did not differentiate between diagnostic groups. Further, alexithymia did not mediate the relationship between diagnosis and quality of life. Somatization was associated with poor quality of life, and patients with PNESs reported greater somatization compared with patients with ESs. Somatization also significantly mediated the relationship between diagnosis and quality of life. In conclusion, somatization may be one mechanism affecting poor quality of life among patients with PNESs compared with ESs and should be a target of comprehensive treatments for PNESs. Alexithymia proved to be an important factor impacting quality of life in both groups and should also be targeted in treatment for patients with PNESs and patients with ESs.
Assuntos
Sintomas Afetivos/etiologia , Sintomas Afetivos/psicologia , Epilepsia/complicações , Epilepsia/psicologia , Qualidade de Vida , Convulsões/complicações , Convulsões/psicologia , Transtornos Somatoformes/etiologia , Transtornos Somatoformes/psicologia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Psicológicos , Testes de Personalidade , Escalas de Graduação Psiquiátrica , Fatores SocioeconômicosRESUMO
Patients with recurrent, stereotyped neurological events of unclear etiology often warrant admission for continuous video-EEG monitoring in an epilepsy monitoring unit (EMU) for diagnosis. Epilepsy monitoring unit admission duration has been reported to range from days to weeks. To date, there are limited data on the average duration of admission for patients admitted to the EMU for spell classification. Many EMUs are forced to limit the overall duration of admission for numerous reasons including limited resources. It is unclear if a time-limited EMU stay reduces the event capture rate and, therefore, diagnostic yield of event classification admissions. The goal of this study was to determine how a time-limited length of stay strategy impacted event capture in patients admitted for spell classification. A retrospective chart review was performed at two comparable adult epilepsy monitoring units, Mayo Clinic Hospital (MCH) in Phoenix, Arizona, and Banner Good Samaritan Medical Center (BGSMC) in Phoenix, Arizona. Banner Good Samaritan Medical Center is only staffed Monday through Friday, thereby limiting the total possible duration of admission to five days. The goal was to determine if the rate of event capture differed between two institutions employing a time-limited EMU admission (BGSMC) when compared with the nonlimited admission (MCH). A total of 300 patient admissions at MCH and 260 patient admissions at BGSMC were reviewed over a comparable time period. The event capture rates at MCH and BGSMC were 74% and 72%, respectively. There was a greater percentage of patients with nonepileptic events (NEEs) at MCH than at BGSMC (62.7% vs. 47.3%). The mean duration until first event was 31h at MCH and 38 h at BGSMC. The mean length of stay was greater at MCH (4.5 days) when compared with BGSMC (3.3 days). The overall diagnostic yield of a time-limited EMU admission was similar to that of a nonlimited admission for the purpose of spell classification. There was a statistically significant difference when comparing the time until first event at both institutions; however, this still fell within the 5-day duration that the time-restricted admission was limited to. These results may be important in optimizing an EMU practice in patients requiring admission for spell classification.
Assuntos
Epilepsia/diagnóstico , Hospitalização/estatística & dados numéricos , Monitorização Fisiológica/normas , Convulsões/diagnóstico , Adulto , Arizona , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Convulsões/classificaçãoRESUMO
The Somatic Complaints scale (SOM) and Conversion subscale (SOM-C) of the Personality Assessment Inventory perform best in classifying psychogenic non-epileptic seizures (PNES) from epileptic seizures (ES); however, the impact of positive impression management (PIM) and negative impression management (NIM) scales on SOM and SOM-C classification has not been examined. We studied 187 patients from an epilepsy monitoring unit with confirmed PNES or ES. On SOM, the best cut score was 72.5 T when PIM was elevated and 69.5 T when there was no bias. On SOM-C, when PIM was elevated, the best cut score was 67.5 T and 76.5 T when there was no bias. Negative impression management elevations (n=9) were too infrequent to analyze separately. Despite similarities in classification accuracy, there were differences in sensitivity and specificity with and without PIM, impacting positive and negative predictive values. The presence of PIM bias generally increases positive predictive power of SOM and SOM-C but decreases negative predictive power.
Assuntos
Epilepsia/psicologia , Inventário de Personalidade , Personalidade , Adulto , Epilepsia/diagnóstico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inventário de Personalidade/normas , Curva ROC , Reprodutibilidade dos Testes , Convulsões/diagnóstico , Convulsões/psicologia , Sensibilidade e EspecificidadeRESUMO
Cerebral edema with declining neurologic status is a known complication of intracranial electroencephalography (EEG) monitoring. The frequency and consequences of iatrogenic edema that is not clinically evident are presently poorly defined. We investigated the potential for intracranial electrodes to cause subclinical cerebral edema, and for such edema to cause iatrogenic seizures. In a retrospective review of 33 adults who had head magnetic resonance imaging (MRI) while undergoing epilepsy surgery evaluation with intracranial EEG, 28% (6 of 21) depth electrode implantations had subclinical vasogenic edema. Of these, 50% (3 of 6) had nonhabitual electrographic seizures that appear to result from iatrogenic edema. No long-term adverse sequelae were noted, however, if unrecognized, iatrogenic seizures could lead to unnecessary exclusion from definitive surgical intervention for refractory epilepsy.
Assuntos
Eletroencefalografia/efeitos adversos , Convulsões/etiologia , Adolescente , Adulto , Idoso , Edema Encefálico/etiologia , Edema Encefálico/patologia , Eletrodos Implantados/efeitos adversos , Epilepsia/diagnóstico , Epilepsia/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Monitorização Fisiológica/efeitos adversos , Convulsões/patologia , Adulto JovemRESUMO
Eyewitnesses frequently perceive seizures as life threatening. If an event occurs on the hospital premises, a "code blue" can be called which consumes considerable resources. The purpose of this study was to determine the frequency and characteristics of code blue calls for seizures and seizure mimickers. A retrospective review of a code blue log from 2001 through 2008 identified 50 seizure-like events, representing 5.3% of all codes. Twenty-eight (54%) occurred in inpatients; the other 22 (44%) events involved visitors or employees on the hospital premises. Eighty-six percent of the events were epileptic seizures. Seizure mimickers, particularly psychogenic nonepileptic seizures, were more common in the nonhospitalized group. Only five (17.9%) inpatients had a known diagnosis of epilepsy, compared with 17 (77.3%) of the nonhospitalized patients. This retrospective survey provides insights into how code blues are called on hospitalized versus nonhospitalized patients for seizure-like events.
Assuntos
Serviços Médicos de Emergência , Convulsões/diagnóstico , Humanos , Monitorização Fisiológica , Convulsões/fisiopatologiaRESUMO
The two most common personality measures used in evaluation of patients on epilepsy monitoring units (EMUs) are the Personality Assessment Inventory (PAI) and the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). Both have been evaluated separately for their ability to distinguish patients with epilepsy from patients with psychogenic events, but they have never been compared directly. The primary aim of this study was to provide comparison data in an EMU population between the PAI, MMPI-2, and the MMPI-2-RF (MMPI-2 Restructured Form). Results show that the PAI Somatic Complaints (SOM) scale and the Conversion subscale (SOM-C), with classification rates of 79%, outperform other indicators from the PAI and indicators from the MMPI-2 and the MMPI-2-RF. Given its other strengths combined with better diagnostic validity performance, the PAI may be the better personality assessment measure for use in distinguishing patients with epilepsy from those with psychogenic seizures in the EMU.
Assuntos
Epilepsia/diagnóstico , MMPI , Determinação da Personalidade , Personalidade , Transtornos Psicofisiológicos/diagnóstico , Adulto , Diagnóstico Diferencial , Epilepsia/psicologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos TestesRESUMO
Epilepsy monitoring unit (EMU) admissions during 2007-2009 at Mayo Clinic Hospital Arizona were reviewed. Of the 106 indeterminate admissions, 13 (12%) went on to have a second admission. During the second admission, 8 (62%) were diagnosed. Five patients went on to have a third or fourth admission, with none of them receiving a diagnosis. Nineteen (18%) patients had ambulatory EEG monitoring after an indeterminate admission, with only one (5%) receiving a diagnosis after ambulatory EEG monitoring. Even in patients who were initially indeterminate, medication management changed 37% of the time. Admission to the EMU was helpful for spell classification, with 80% of the patients receiving a diagnosis after the first admission. Based on this study, a second admission should be considered if no diagnosis is reached after the first admission. If no diagnosis is made after the second EMU admission, subsequent admissions are unlikely to produce a definitive diagnosis.
Assuntos
Eletroencefalografia/métodos , Epilepsia/diagnóstico , Monitorização Ambulatorial/métodos , Feminino , Humanos , MasculinoRESUMO
The study of the electroencephalogram (EEG) and other clinical neurophysiology (CNP) measurement tools has evolved over the last 70 years. In this evolutionary process, Ellen Grass and many professional technologists along the way have been instrumental in the translation of new developments in CNP technology to clinical utility. Technological developments in long-term EEG/video intensive care unit (ICU) monitoring, intraoperative monitoring, high frequency oscillation (HFO) recordings, automated signal analysis tools, seizure prediction devices, and the study of implanted intracranial recording and stimulation devices will improve our understanding of how the nervous system works. Improved understanding and translation of this evolving technology for improved patient care and outcomes remains the ultimate goal of such endeavors. Professional organizations such as the American Board of Registration of Electroencephalographic and Evoked Potential Technologists (ABRET) and the American Society of Electroneurodiagnostic Technologists (ASET) must continue to serve the CNP community and society to guide the application of this technology with an emphasis on providing information, guidelines on its use, and setting standards of professionalism. Any prior prediction of the demise of CNP technology has been greatly exaggerated. Quite the opposite has occurred, considering that the humble origins of vacuum tube powered Grass EEG machines will eventually yield to intracranial implanted microchip based recording and stimulation devices; the future appears bright for our profession.
Assuntos
Eletroencefalografia/história , Neurofisiologia/história , Eletroencefalografia/métodos , Eletroencefalografia/tendências , Epilepsia/diagnóstico , História do Século XX , Humanos , Neurofisiologia/métodos , Neurofisiologia/tendênciasRESUMO
Olfactory and gustatory hallucinations are not often encountered in the acute care setting but may represent the subtle presenting features of a significant underlying disease process. We describe a patient whose most striking presenting symptoms were of olfactory and gustatory hallucinations and in whom the diagnosis and treatment of a new brain tumor and partial status epilepticus occurred entirely in the emergency department. The lesion was subsequently identified as glioblastoma multiforme involving the hippocampus and amygdala.
Assuntos
Neoplasias Encefálicas/complicações , Glioblastoma/complicações , Alucinações/etiologia , Estado Epiléptico/etiologia , Tonsila do Cerebelo/patologia , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/patologia , Glioblastoma/diagnóstico , Glioblastoma/patologia , Hipocampo/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios XRESUMO
Driving for the person with epilepsy (PWE) remains an important issue. Requirements for reporting PWE to driving authorities vary across the United States. We studied the prior experiences of PWE regarding counseling for driving in a reporting state (37% in New Jersey) and a nonreporting state (52% in Arizona). A prospective voluntary anonymous survey was conducted among patients with new-onset epilepsy at two epilepsy referral centers. Subjects were queried about prior interactions with health care professionals regarding attitudes toward and knowledge of driving regulations. Practitioners caring for PWE are in the position to provide advice and counsel regarding driving regulations. Fifty percent or fewer subjects were appropriately counseled, regardless of residence requirements. PWE felt they were honest with their physician and 10% of subjects have driven against medical advice. A performance gap exists in the appropriate counseling regarding driving for PWE that has potentially significant safety and legal implications.
Assuntos
Atitude do Pessoal de Saúde , Condução de Veículo , Aconselhamento/legislação & jurisprudência , Epilepsia/psicologia , Médicos/psicologia , Acidentes de Trânsito/estatística & dados numéricos , Adolescente , Adulto , Condução de Veículo/legislação & jurisprudência , Condução de Veículo/psicologia , Aconselhamento/estatística & dados numéricos , Coleta de Dados , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Relações Médico-Paciente , Estudos Prospectivos , Estados Unidos , Adulto JovemRESUMO
The Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) is a restructuring of the MMPI-2 that has improved the psychometric characteristics of the test. The primary aim of this study was to provide diagnostic utility data on the MMPI-2-RF in an epilepsy monitoring unit population (N=429). Mean comparisons revealed group differences on Validity Scales Fs and FBS-r; Restructured Clinical Scales RC1 and RC3; and Somatic Scales MLS, GIC, HPC, and NUC. Diagnostic utility data are provided for those scales with the largest effect sizes: RC1, FBS-r, and NUC. On RC1, sensitivity was 76% and specificity was 60%, similar to values found when applying published decision rules to the MMPI-2. RC1 explains unique variance in diagnosis beyond that explained by demographic or medical history risk factors. We provide likelihood ratios for scores on RC1, FBS-r, and NUC that can be used by the clinician to calculate posttest odds and probability of nonepileptic seizures using the base rate of nonepileptic seizures in his/her population.
Assuntos
Anticonvulsivantes/uso terapêutico , Epilepsia , MMPI , Transtornos da Personalidade/diagnóstico , Transtornos da Personalidade/epidemiologia , Adulto , Transtornos Cognitivos/diagnóstico , Transtornos Cognitivos/epidemiologia , Epilepsia/tratamento farmacológico , Epilepsia/epidemiologia , Epilepsia/psicologia , Feminino , Humanos , Relações Interpessoais , Masculino , Testes Neuropsicológicos , Índice de Gravidade de DoençaRESUMO
In Arizona, other states, and other countries, people who experience a seizure or other transient alteration of consciousness may be legally restricted from driving. Arizona law requires that people with these conditions submit themselves for a medical review, whereas health care providers are not required to report to the authorities. Therefore, counseling people with these medical conditions about driving generally falls to health care providers, who are often not neurologists. Three hundred thirty-five consecutive charts of patients discharged from our Emergency Department were retrospectively reviewed by diagnosis codes associated with altered consciousness. A total of 267 patients met our inclusion criteria, of whom 27 (10.1%) were counseled regarding driving--by the Emergency Department physician and/or consulting neurologist. Although the counseling rate for driving was 10/29 (34.5%) when a neurologist was involved, it was found to be only 17/238 (7.1%) when neurological services were not sought. Patients presenting with seizure were more likely to be counseled than those presenting with other episodes of loss of consciousness. Accurate knowledge of driving laws by health care workers and patients has the potential to minimize liability and improve public safety and quality of care.
Assuntos
Condução de Veículo/psicologia , Transtornos da Consciência/psicologia , Aconselhamento , Epilepsia/psicologia , Arizona , Humanos , Médicos de Família , Estudos RetrospectivosRESUMO
This study was designed to evaluate the utility of subtraction ictal SPECT coregistered to MRI (SISCOM) in atypical psychogenic nonepileptic seizures (PNES). Video-EEG monitoring (vEEG) is the gold standard for PNES diagnosis but, like any modality, has limitations. In difficult cases in which the diagnosis is suspected but remains in question after vEEG, a complementary study that could help differentiate epilepsy from PNES would be desirable. Thirteen SISCOM studies performed in patients with a final diagnosis of PNES were retrospectively reviewed. Common indications for SISCOM were semiology consistent with partial epilepsy (9/13), abnormal head MRI (5/13), and reported abnormal routine EEG (5/13). SISCOM was negative in 85% (11/13) of patients and was helpful in increasing the diagnostic certainty of PNES in these exceptional cases.
Assuntos
Eletroencefalografia/métodos , Epilepsia , Transtornos Psicofisiológicos , Tomografia Computadorizada de Emissão de Fóton Único/métodos , Gravação em Vídeo/métodos , Adolescente , Adulto , Idoso , Mapeamento Encefálico , Cisteína/análogos & derivados , Cisteína/efeitos dos fármacos , Epilepsia/complicações , Epilepsia/diagnóstico por imagem , Epilepsia/fisiopatologia , Feminino , Lateralidade Funcional , Humanos , Masculino , Pessoa de Meia-Idade , Compostos de Organotecnécio , Inventário de Personalidade , Transtornos Psicofisiológicos/complicações , Transtornos Psicofisiológicos/diagnóstico por imagem , Transtornos Psicofisiológicos/fisiopatologia , Estudos Retrospectivos , Fatores de Risco , Adulto JovemRESUMO
Both variegate and acute intermittent porphyria can manifest with various neurological symptoms. Although acute symptomatic seizures have been previously described, they are typically tonic-clonic and focal impaired awareness seizures. Convulsive status epilepticus and epilepsia partialis continua are rare and have been described on a case report basis. To our knowledge, there are no previously reported cases describing non-convulsive status epilepticus (NCSE) with electroencephalogram (EEG) documentation in the setting of acute porphyria crisis. We report a unique presentation of NCSE, which resolved after administering levetiracetam in a patient with variegate porphyria, without a known seizure disorder.
RESUMO
A subsample of 67 adult patients with partial seizures participating in a randomized, double-blind study comparing the cognitive effects of adjunctive lamotrigine (LTG) and adjunctive topiramate (TPM) was administered Performance On-Line (POL) in addition to a battery of neuropsychological tests at baseline, week 8 and week 16 of treatment. The POL is a self-administered computer task that measures scanning, divided-attention, and the effective field of view. Although the POL does not measure driving performance, POL scores are correlated with driving performance. The results show that adjunctive TPM, but not adjunctive LTG, negatively impacted cognition. Both simple target identification and divided-attention performance on POL were compromised in the TPM group but not in the LTG group. The relative POL impairment associated with chronic TPM treatment was similar to that observed with the acute effects of alcohol with a breath level of .045% or a low dose of alprazolam (0.5mg). Thus, driving-related visual and cognitive skills were compromised by adjunctive TPM treatment. Therapeutic doses of adjunctive TPM pose a potential risk of impaired scanning and divided-attention skills.