Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma.

Boumahdi, Soufiane; Driessens, Gregory; Lapouge, Gaelle; Rorive, Sandrine; Nassar, Dany; Le Mercier, Marie; Delatte, Benjamin; Caauwe, Amélie; Lenglez, Sandrine; Nkusi, Erwin; Brohée, Sylvain; Salmon, Isabelle; Dubois, Christine; del Marmol, Veronique; Fuks, Francois; Beck, Benjamin; Blanpain, Cédric.

Nature ; 511(7508): 246-50, 2014 Jul 10.

Artigo em Inglês | MEDLINE | ID: mdl-24909994

2.

Defining the mode of tumour growth by clonal analysis.

Driessens, Gregory; Beck, Benjamin; Caauwe, Amélie; Simons, Benjamin D; Blanpain, Cédric.

Nature ; 488(7412): 527-30, 2012 Aug 23.

Artigo em Inglês | MEDLINE | ID: mdl-22854777

3.

A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours.

Beck, Benjamin; Driessens, Gregory; Goossens, Steven; Youssef, Khalil Kass; Kuchnio, Anna; Caauwe, Amélie; Sotiropoulou, Panagiota A; Loges, Sonja; Lapouge, Gaelle; Candi, Aurélie; Mascre, Guilhem; Drogat, Benjamin; Dekoninck, Sophie; Haigh, Jody J; Carmeliet, Peter; Blanpain, Cédric.

Nature ; 478(7369): 399-403, 2011 Oct 19.

Artigo em Inglês | MEDLINE | ID: mdl-22012397

4.

Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction.

Locke, Frederick L; Zha, Yuan-yuan; Zheng, Yan; Driessens, Gregory; Gajewski, Thomas F.

J Immunol ; 191(4): 1677-85, 2013 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-23851688

5.

Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-Î³1 phosphorylation.

Driessens, Gregory; Zheng, Yan; Locke, Frederick; Cannon, Judy L; Gounari, Fotini; Gajewski, Thomas F.

J Immunol ; 186(2): 784-90, 2011 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-21149602

6.

Costimulatory and coinhibitory receptors in anti-tumor immunity.

Driessens, Gregory; Kline, Justin; Gajewski, Thomas F.

Immunol Rev ; 229(1): 126-44, 2009 May.

Artigo em Inglês | MEDLINE | ID: mdl-19426219

7.

TIGIT inhibition and lenalidomide synergistically promote antimyeloma immune responses after stem cell transplantation in mice.

Minnie, Simone A; Waltner, Olivia G; Ensbey, Kathleen S; Olver, Stuart D; Collinge, Alika D; Sester, David P; Schmidt, Christine R; Legg, Samuel Rw; Takahashi, Shuichiro; Nemychenkov, Nicole S; Sekiguchi, Tomoko; Driessens, Gregory; Zhang, Ping; Koyama, Motoko; Spencer, Andrew; Holmberg, Leona A; Furlan, Scott N; Varelias, Antiopi; Hill, Geoffrey R.

J Clin Invest ; 133(4)2023 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-36512425

8.

A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library.

Takacs, Zoltan; Toups, Megan; Kollewe, Astrid; Johnson, Erik; Cuello, Luis G; Driessens, Gregory; Biancalana, Matthew; Koide, Akiko; Ponte, Cristiano G; Perozo, Eduardo; Gajewski, Thomas F; Suarez-Kurtz, Guilherme; Koide, Shohei; Goldstein, Steve A N.

Proc Natl Acad Sci U S A ; 106(52): 22211-6, 2009 Dec 29.

Artigo em Inglês | MEDLINE | ID: mdl-20007782

9.

Development of a successful antitumor therapeutic model combining in vivo dendritic cell vaccination with tumor irradiation and intratumoral GM-CSF delivery.

Driessens, Gregory; Nuttin, Lise; Gras, Alain; Maetens, Julie; Mievis, Stephane; Schoore, Marylène; Velu, Thierry; Tenenbaum, Liliane; Préat, Véronique; Bruyns, Catherine.

Cancer Immunol Immunother ; 60(2): 273-81, 2011 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-21076828

10.

Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies.

Preillon, Julie; Cuende, Julia; Rabolli, Virginie; Garnero, Lucile; Mercier, Marjorie; Wald, Noémie; Pappalardo, Angela; Denies, Sofie; Jamart, Diane; Michaux, Anne-Catherine; Pirson, Romain; Pitard, Vincent; Bagot, Martine; Prasad, Shruthi; Houthuys, Erica; Brouwer, Margreet; Marillier, Reece; Lambolez, Florence; Marchante, Joäo R; Nyawouame, Florence; Carter, Mathew J; Baron-Bodo, Véronique; Marie-Cardine, Anne; Cragg, Mark; Déchanet-Merville, Julie; Driessens, Gregory; Hoofd, Catherine.

Mol Cancer Ther ; 20(1): 121-131, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33277440

11.

Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint Inhibitors.

Schramme, Florence; Crosignani, Stefano; Frederix, Kim; Hoffmann, Delia; Pilotte, Luc; Stroobant, Vincent; Preillon, Julie; Driessens, Gregory; Van den Eynde, Benoit J.

Cancer Immunol Res ; 8(1): 32-45, 2020 01.

Artigo em Inglês | MEDLINE | ID: mdl-31806638

12.

Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy.

Gomes, Bruno; Driessens, Gregory; Bartlett, Derek; Cai, Danying; Cauwenberghs, Sandra; Crosignani, Stefano; Dalvie, Deepak; Denies, Sofie; Dillon, Christopher P; Fantin, Valeria R; Guo, Jie; Letellier, Marie-Claire; Li, Wenlin; Maegley, Karen; Marillier, Reece; Miller, Nichol; Pirson, Romain; Rabolli, Virginie; Ray, Chad; Streiner, Nicole; Torti, Vince R; Tsaparikos, Konstantinos; Van den Eynde, Benoit J; Wythes, Martin; Yao, Li-Chin; Zheng, Xianxian; Tumang, Joseph; Kraus, Manfred.

Mol Cancer Ther ; 17(12): 2530-2542, 2018 12.

Artigo em Inglês | MEDLINE | ID: mdl-30232146

13.

15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism.

Willermain, François; Dulku, Simon; Gonzalez, Nathalie Suarez; Blero, Daniel; Driessens, Gregory; De Graef, Chantal; Caspers, Laure; Bruyns, Catherine.

Prostaglandins Other Lipid Mediat ; 80(3-4): 136-43, 2006 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-16939878

14.

Highly successful therapeutic vaccinations combining dendritic cells and tumor cells secreting granulocyte macrophage colony-stimulating factor.

Driessens, Gregory; Hamdane, Malika; Cool, Vincent; Velu, Thierry; Bruyns, Catherine.

Cancer Res ; 64(22): 8435-42, 2004 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-15548715

15.

Assessment of in vivo chemotherapy-induced DNA damage in a p53-mutated rat tumor by micronuclei assay.

Driessens, Gregory; Harsan, Laura; Browaeys, Patrick; Giannakopoulos, Xenofon; Velu, Thierry; Bruyns, Catherine.

Ann N Y Acad Sci ; 1010: 775-9, 2003 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-15033826

16.

Deciphering tumor growth by clonal analysis.

Driessens, Gregory.

Crit Rev Oncog ; 19(5): 317-25, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-25404147

17.

Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo.

Zheng, Yan; Zha, Yuanyuan; Driessens, Gregory; Locke, Frederick; Gajewski, Thomas F.

J Exp Med ; 209(12): 2157-63, 2012 Nov 19.

Artigo em Inglês | MEDLINE | ID: mdl-23129747

18.

Long live sox2: sox2 lasts a lifetime.

Driessens, Grégory; Blanpain, Cédric.

Cell Stem Cell ; 9(4): 283-4, 2011 Oct 04.

Artigo em Inglês | MEDLINE | ID: mdl-21982223

19.

Synergy between dendritic cells and GM-CSF-secreting tumor cells for the treatment of a murine renal cell carcinoma.

Driessens, Gregory; Hoffmann, Paul; Pouwels, Michael; Zlotta, Alexandre; Schulman, Claude; Velu, Thierry; Bruyns, Catherine A.

J Immunother ; 32(2): 140-4, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-19238012

20.

Therapeutic efficacy of antitumor dendritic cell vaccinations correlates with persistent Th1 responses, high intratumor CD8+ T cell recruitment and low relative regulatory T cell infiltration.

Driessens, Gregory; Gordower, Laurence; Nuttin, Lise; Stordeur, Patrick; Blocklet, Didier; Egrise, Dominique; Velu, Thierry; Bruyns, Catherine.

Cancer Immunol Immunother ; 57(12): 1745-56, 2008 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-18369621

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