1.
Org Lett
; 3(11): 1689-92, 2001 May 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11405687
RESUMO
Recent efforts in our laboratories have resulted in a synthetic approach toward C2'-alkylated K252a analogues via extension of a K252a cyclofuranosylation strategy. The bis-indole-N-glycosidic coupling of 6-N-(3,4-dimethoxybenzyl)-staurosporinone (21) with a number of highly functionalized carbohydrates has given access to previously unattainable, biologically relevant analogues.
Assuntos
Carbazóis/síntese química , Inibidores Enzimáticos/síntese química , Proteína Quinase C/antagonistas & inibidores , Alquilação , Indicadores e Reagentes , Alcaloides Indólicos , Conformação Molecular , Estereoisomerismo
2.
J Org Chem
; 66(21): 7025-9, 2001 Oct 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11597224
RESUMO
We describe a short, enantioselective synthesis of the naturally occurring pyrrolizidine alkaloid (+)-latifoline (1) employing a tandem [3,3] sigmatropic rearrangement/[1,2] allyl shift as a key step in constructing (+)-latifolic acid (4).