Detalhe da pesquisa
1.
The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation.
J Biol Chem
; 300(1): 105501, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38016516
2.
An Epigenomic fingerprint of human cancers by landscape interrogation of super enhancers at the constituent level.
PLoS Comput Biol
; 20(2): e1011873, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38335222
3.
Structure-independent machine learning predictions of the CDK12 interactome.
Biophys J
; 2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38762754
4.
Summarizing internal dynamics boosts differential analysis and functional interpretation of super enhancers.
Nucleic Acids Res
; 50(6): 3115-3127, 2022 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35234924
5.
Response and resistance to CDK12 inhibition in aggressive B-cell lymphomas.
Haematologica
; 107(5): 1119-1130, 2022 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34162179
6.
Design of a small molecule against an oncogenic noncoding RNA.
Proc Natl Acad Sci U S A
; 113(21): 5898-903, 2016 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27170187
7.
A stress response pathway regulates DNA damage through ß2-adrenoreceptors and ß-arrestin-1.
Nature
; 477(7364): 349-53, 2011 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21857681
8.
Identification of an EGFRvIII-JNK2-HGF/c-Met-Signaling Axis Required for Intercellular Crosstalk and Glioblastoma Multiforme Cell Invasion.
Mol Pharmacol
; 88(6): 962-9, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26452771
9.
Antiproliferation activity of a small molecule repressor of liver receptor homolog 1.
Mol Pharmacol
; 87(2): 296-304, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25473120
10.
Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors.
Bioorg Med Chem Lett
; 23(9): 2683-7, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23518277
11.
Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties.
Bioorg Med Chem Lett
; 23(15): 4374-80, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23787102
12.
Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ.
J Med Chem
; 66(11): 7162-7178, 2023 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37204207
13.
Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target.
ACS Chem Biol
; 18(2): 251-264, 2023 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36630201
14.
Coordination games in cancer.
PLoS One
; 17(1): e0261578, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35061724
15.
Identification of Immunogenic MHC Class II Human HER3 Peptides that Mediate Anti-HER3 CD4+ Th1 Responses and Potential Use as a Cancer Vaccine.
Cancer Immunol Res
; 10(1): 108-125, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34785506
16.
Synthesis and SAR of 2-phenoxypyridines as novel c-Jun N-terminal kinase inhibitors.
Bioorg Med Chem Lett
; 21(23): 7072-5, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22004719
17.
Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors.
Bioorg Med Chem Lett
; 21(9): 2732-5, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21185177
18.
The promise and current status of CDK12/13 inhibition for the treatment of cancer.
Future Med Chem
; 13(2): 117-141, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33295810
19.
Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the ß-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.
J Med Chem
; 64(16): 12109-12131, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34382808
20.
Targeted Therapy Given after Anti-PD-1 Leads to Prolonged Responses in Mouse Melanoma Models through Sustained Antitumor Immunity.
Cancer Immunol Res
; 9(5): 554-567, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33653716