Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Whole-exome sequencing identifies rare genetic variants associated with human plasma metabolites.

Bomba, Lorenzo; Walter, Klaudia; Guo, Qi; Surendran, Praveen; Kundu, Kousik; Nongmaithem, Suraj; Karim, Mohd Anisul; Stewart, Isobel D; Langenberg, Claudia; Danesh, John; Di Angelantonio, Emanuele; Roberts, David J; Ouwehand, Willem H; Dunham, Ian; Butterworth, Adam S; Soranzo, Nicole.

Am J Hum Genet ; 109(6): 1038-1054, 2022 06 02.

Artigo em Inglês | MEDLINE | ID: mdl-35568032

2.

ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.

Law, Martin J; Lower, Karen M; Voon, Hsiao P J; Hughes, Jim R; Garrick, David; Viprakasit, Vip; Mitson, Matthew; De Gobbi, Marco; Marra, Marco; Morris, Andrew; Abbott, Aaron; Wilder, Steven P; Taylor, Stephen; Santos, Guilherme M; Cross, Joe; Ayyub, Helena; Jones, Steven; Ragoussis, Jiannis; Rhodes, Daniela; Dunham, Ian; Higgs, Douglas R; Gibbons, Richard J.

Cell ; 143(3): 367-78, 2010 Oct 29.

Artigo em Inglês | MEDLINE | ID: mdl-21029860

3.

The next-generation Open Targets Platform: reimagined, redesigned, rebuilt.

Ochoa, David; Hercules, Andrew; Carmona, Miguel; Suveges, Daniel; Baker, Jarrod; Malangone, Cinzia; Lopez, Irene; Miranda, Alfredo; Cruz-Castillo, Carlos; Fumis, Luca; Bernal-Llinares, Manuel; Tsukanov, Kirill; Cornu, Helena; Tsirigos, Konstantinos; Razuvayevskaya, Olesya; Buniello, Annalisa; Schwartzentruber, Jeremy; Karim, Mohd; Ariano, Bruno; Martinez Osorio, Ricardo Esteban; Ferrer, Javier; Ge, Xiangyu; Machlitt-Northen, Sandra; Gonzalez-Uriarte, Asier; Saha, Shyamasree; Tirunagari, Santosh; Mehta, Chintan; Roldán-Romero, Juan María; Horswell, Stuart; Young, Sarah; Ghoussaini, Maya; Hulcoop, David G; Dunham, Ian; McDonagh, Ellen M.

Nucleic Acids Res ; 51(D1): D1353-D1359, 2023 Jan 06.

Artigo em Inglês | MEDLINE | ID: mdl-36399499

4.

Open Targets Platform: supporting systematic drug-target identification and prioritisation.

Ochoa, David; Hercules, Andrew; Carmona, Miguel; Suveges, Daniel; Gonzalez-Uriarte, Asier; Malangone, Cinzia; Miranda, Alfredo; Fumis, Luca; Carvalho-Silva, Denise; Spitzer, Michaela; Baker, Jarrod; Ferrer, Javier; Raies, Arwa; Razuvayevskaya, Olesya; Faulconbridge, Adam; Petsalaki, Eirini; Mutowo, Prudence; Machlitt-Northen, Sandra; Peat, Gareth; McAuley, Elaine; Ong, Chuang Kee; Mountjoy, Edward; Ghoussaini, Maya; Pierleoni, Andrea; Papa, Eliseo; Pignatelli, Miguel; Koscielny, Gautier; Karim, Mohd; Schwartzentruber, Jeremy; Hulcoop, David G; Dunham, Ian; McDonagh, Ellen M.

Nucleic Acids Res ; 49(D1): D1302-D1310, 2021 01 08.

Artigo em Inglês | MEDLINE | ID: mdl-33196847

5.

Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics.

Ghoussaini, Maya; Mountjoy, Edward; Carmona, Miguel; Peat, Gareth; Schmidt, Ellen M; Hercules, Andrew; Fumis, Luca; Miranda, Alfredo; Carvalho-Silva, Denise; Buniello, Annalisa; Burdett, Tony; Hayhurst, James; Baker, Jarrod; Ferrer, Javier; Gonzalez-Uriarte, Asier; Jupp, Simon; Karim, Mohd Anisul; Koscielny, Gautier; Machlitt-Northen, Sandra; Malangone, Cinzia; Pendlington, Zoe May; Roncaglia, Paola; Suveges, Daniel; Wright, Daniel; Vrousgou, Olga; Papa, Eliseo; Parkinson, Helen; MacArthur, Jacqueline A L; Todd, John A; Barrett, Jeffrey C; Schwartzentruber, Jeremy; Hulcoop, David G; Ochoa, David; McDonagh, Ellen M; Dunham, Ian.

Nucleic Acids Res ; 49(D1): D1311-D1320, 2021 01 08.

Artigo em Inglês | MEDLINE | ID: mdl-33045747

6.

The open targets post-GWAS analysis pipeline.

Peat, Gareth; Jones, William; Nuhn, Michael; Marugán, José Carlos; Newell, William; Dunham, Ian; Zerbino, Daniel.

Bioinformatics ; 36(9): 2936-2937, 2020 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-31930349

7.

Human genes: Time to follow the roads less traveled?

Dunham, Ian.

PLoS Biol ; 16(9): e3000034, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-30256779

8.

Using human genetics to make new medicines.

Barrett, Jeffrey C; Dunham, Ian; Birney, Ewan.

Nat Rev Genet ; 16(10): 561-2, 2015 10.

Artigo em Inglês | MEDLINE | ID: mdl-26370900

9.

Open Targets Platform: new developments and updates two years on.

Carvalho-Silva, Denise; Pierleoni, Andrea; Pignatelli, Miguel; Ong, ChuangKee; Fumis, Luca; Karamanis, Nikiforos; Carmona, Miguel; Faulconbridge, Adam; Hercules, Andrew; McAuley, Elaine; Miranda, Alfredo; Peat, Gareth; Spitzer, Michaela; Barrett, Jeffrey; Hulcoop, David G; Papa, Eliseo; Koscielny, Gautier; Dunham, Ian.

Nucleic Acids Res ; 47(D1): D1056-D1065, 2019 01 08.

Artigo em Inglês | MEDLINE | ID: mdl-30462303

10.

eFORGE v2.0: updated analysis of cell type-specific signal in epigenomic data.

Breeze, Charles E; Reynolds, Alex P; van Dongen, Jenny; Dunham, Ian; Lazar, John; Neph, Shane; Vierstra, Jeff; Bourque, Guillaume; Teschendorff, Andrew E; Stamatoyannopoulos, John A; Beck, Stephan.

Bioinformatics ; 35(22): 4767-4769, 2019 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-31161210

11.

Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands.

Freudenberg, Johannes M; Dunham, Ian; Sanseau, Philippe; Rajpal, Deepak K.

BMC Bioinformatics ; 19(1): 345, 2018 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-30285606

12.

Mining a GWAS of Severe Covid-19.

Karim, Mohd; Dunham, Ian; Ghoussaini, Maya.

N Engl J Med ; 383(26): 2588-2589, 2020 12 24.

Artigo em Inglês | MEDLINE | ID: mdl-33289971

13.

Where Next for Genetics and Genomics?

Tyler-Smith, Chris; Yang, Huanming; Landweber, Laura F; Dunham, Ian; Knoppers, Bartha M; Donnelly, Peter; Mardis, Elaine R; Snyder, Michael; McVean, Gil.

PLoS Biol ; 13(7): e1002216, 2015 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-26225775

14.

Correction: Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association.

Ding, Zhihao; Ni, Yunyun; Timmer, Sander W; Lee, Bum-Kyu; Battenhouse, Anna; Louzada, Sandra; Yang, Fengtang; Dunham, Ian; Crawford, Gregory E; Lieb, Jason D; Durbin, Richard; Iyer, Vishwanath R; Birney, Ewan.

PLoS Genet ; 11(4): e1005177, 2015 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-25919664

15.

Functional annotation of noncoding sequence variants.

Ritchie, Graham R S; Dunham, Ian; Zeggini, Eleftheria; Flicek, Paul.

Nat Methods ; 11(3): 294-6, 2014 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-24487584

16.

In silico prediction of novel therapeutic targets using gene-disease association data.

Ferrero, Enrico; Dunham, Ian; Sanseau, Philippe.

J Transl Med ; 15(1): 182, 2017 08 29.

Artigo em Inglês | MEDLINE | ID: mdl-28851378

17.

Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association.

Ding, Zhihao; Ni, Yunyun; Timmer, Sander W; Lee, Bum-Kyu; Battenhouse, Anna; Louzada, Sandra; Yang, Fengtang; Dunham, Ian; Crawford, Gregory E; Lieb, Jason D; Durbin, Richard; Iyer, Vishwanath R; Birney, Ewan.

PLoS Genet ; 10(11): e1004798, 2014 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-25411781

18.

Defining functional DNA elements in the human genome.

Kellis, Manolis; Wold, Barbara; Snyder, Michael P; Bernstein, Bradley E; Kundaje, Anshul; Marinov, Georgi K; Ward, Lucas D; Birney, Ewan; Crawford, Gregory E; Dekker, Job; Dunham, Ian; Elnitski, Laura L; Farnham, Peggy J; Feingold, Elise A; Gerstein, Mark; Giddings, Morgan C; Gilbert, David M; Gingeras, Thomas R; Green, Eric D; Guigo, Roderic; Hubbard, Tim; Kent, Jim; Lieb, Jason D; Myers, Richard M; Pazin, Michael J; Ren, Bing; Stamatoyannopoulos, John A; Weng, Zhiping; White, Kevin P; Hardison, Ross C.

Proc Natl Acad Sci U S A ; 111(17): 6131-8, 2014 Apr 29.

Artigo em Inglês | MEDLINE | ID: mdl-24753594

19.

Integrative annotation of chromatin elements from ENCODE data.

Hoffman, Michael M; Ernst, Jason; Wilder, Steven P; Kundaje, Anshul; Harris, Robert S; Libbrecht, Max; Giardine, Belinda; Ellenbogen, Paul M; Bilmes, Jeffrey A; Birney, Ewan; Hardison, Ross C; Dunham, Ian; Kellis, Manolis; Noble, William Stafford.

Nucleic Acids Res ; 41(2): 827-41, 2013 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-23221638

20.

Ensembl 2013.

Flicek, Paul; Ahmed, Ikhlak; Amode, M Ridwan; Barrell, Daniel; Beal, Kathryn; Brent, Simon; Carvalho-Silva, Denise; Clapham, Peter; Coates, Guy; Fairley, Susan; Fitzgerald, Stephen; Gil, Laurent; García-Girón, Carlos; Gordon, Leo; Hourlier, Thibaut; Hunt, Sarah; Juettemann, Thomas; Kähäri, Andreas K; Keenan, Stephen; Komorowska, Monika; Kulesha, Eugene; Longden, Ian; Maurel, Thomas; McLaren, William M; Muffato, Matthieu; Nag, Rishi; Overduin, Bert; Pignatelli, Miguel; Pritchard, Bethan; Pritchard, Emily; Riat, Harpreet Singh; Ritchie, Graham R S; Ruffier, Magali; Schuster, Michael; Sheppard, Daniel; Sobral, Daniel; Taylor, Kieron; Thormann, Anja; Trevanion, Stephen; White, Simon; Wilder, Steven P; Aken, Bronwen L; Birney, Ewan; Cunningham, Fiona; Dunham, Ian; Harrow, Jennifer; Herrero, Javier; Hubbard, Tim J P; Johnson, Nathan; Kinsella, Rhoda.

Nucleic Acids Res ; 41(Database issue): D48-55, 2013 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-23203987

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