Detalhe da pesquisa
1.
Optimized arylomycins are a new class of Gram-negative antibiotics.
Nature
; 561(7722): 189-194, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30209367
2.
Effects of inhaled JAK inhibitor GDC-4379 on exhaled nitric oxide and peripheral biomarkers of inflammation.
Pulm Pharmacol Ther
; 75: 102133, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-35644305
3.
Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma: A randomized, controlled, proof-of-activity trial.
J Allergy Clin Immunol
; 148(3): 783-789, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33744327
4.
Impact of age, hypercholesterolemia, and the vitamin D receptor on brain endogenous ß-amyloid peptide accumulation in mice.
Biopharm Drug Dispos
; 42(8): 372-388, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34219248
5.
Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing in Microdialysis Studies in Rats.
Drug Metab Dispos
; 46(7): 964-969, 2018 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-29700231
6.
1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-ß accumulation and improves cognition in mouse models of Alzheimer's disease.
J Neurosci
; 34(21): 7091-101, 2014 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24849345
7.
Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.
Gastroenterology
; 146(4): 1048-59, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24365583
8.
Vitamin D receptor activation induces P-glycoprotein and increases brain efflux of quinidine: an intracerebral microdialysis study in conscious rats.
Pharm Res
; 32(3): 1128-40, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25319098
9.
Comparative effects of 1α-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on transporters and enzymes in fxr(+/+) and fxr(-/-) mice.
Biopharm Drug Dispos
; 34(7): 402-16, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23897575
10.
Lipid Tales: Optimizing Arylomycin Membrane Anchors.
ACS Med Chem Lett
; 14(11): 1524-1530, 2023 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37974942
11.
1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells.
J Neurochem
; 123(6): 944-53, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23035695
12.
Elucidating a Potential Mechanism of Permeability Enhancer Sodium N-[8-(2-hydroxybenzoyl) amino] Caprylate in Rats: Evidence of Lymphatic Absorption of Cyanocobalamin using the Mesenteric Lymph Duct Cannulated Rat.
J Pharm Sci
; 111(12): 3417-3423, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36228756
13.
Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation.
J Med Chem
; 65(13): 8713-8734, 2022 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35790118
14.
Phase I and scintigraphy studies to evaluate safety, tolerability, pharmacokinetics, and lung deposition of inhaled GDC-0214 in healthy volunteers.
Clin Transl Sci
; 15(5): 1225-1237, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35157370
15.
1Alpha,25-dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo.
J Pharmacol Exp Ther
; 337(3): 846-59, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21421739
16.
1α,25-dihydroxyvitamin D3 on intestinal transporter function: studies with the rat everted intestinal sac.
Biopharm Drug Dispos
; 32(2): 112-25, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21341280
17.
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor.
ACS Med Chem Lett
; 12(5): 791-797, 2021 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34055227
18.
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3H)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor.
J Med Chem
; 64(7): 3940-3955, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33780623
19.
Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion.
J Pharmacokinet Pharmacodyn
; 37(6): 591-615, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21153869
20.
Complex DDI by Fenebrutinib and the Use of Transporter Endogenous Biomarkers to Elucidate the Mechanism of DDI.
Clin Pharmacol Ther
; 107(1): 269-277, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31376152