Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression.

Sanidas, Ioannis; Lee, Hanjun; Rumde, Purva H; Boulay, Gaylor; Morris, Robert; Golczer, Gabriel; Stanzione, Marcelo; Hajizadeh, Soroush; Zhong, Jun; Ryan, Meagan B; Corcoran, Ryan B; Drapkin, Benjamin J; Rivera, Miguel N; Dyson, Nicholas J; Lawrence, Michael S.

Mol Cell ; 82(18): 3333-3349.e9, 2022 09 15.

Artigo em Inglês | MEDLINE | ID: mdl-35981542

2.

Therapy-induced APOBEC3A drives evolution of persistent cancer cells.

Isozaki, Hideko; Sakhtemani, Ramin; Abbasi, Ammal; Nikpour, Naveed; Stanzione, Marcello; Oh, Sunwoo; Langenbucher, Adam; Monroe, Susanna; Su, Wenjia; Cabanos, Heidie Frisco; Siddiqui, Faria M; Phan, Nicole; Jalili, Pégah; Timonina, Daria; Bilton, Samantha; Gomez-Caraballo, Maria; Archibald, Hannah L; Nangia, Varuna; Dionne, Kristin; Riley, Amanda; Lawlor, Matthew; Banwait, Mandeep Kaur; Cobb, Rosemary G; Zou, Lee; Dyson, Nicholas J; Ott, Christopher J; Benes, Cyril; Getz, Gad; Chan, Chang S; Shaw, Alice T; Gainor, Justin F; Lin, Jessica J; Sequist, Lecia V; Piotrowska, Zofia; Yeap, Beow Y; Engelman, Jeffrey A; Lee, Jake June-Koo; Maruvka, Yosef E; Buisson, Rémi; Lawrence, Michael S; Hata, Aaron N.

Nature ; 620(7973): 393-401, 2023 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-37407818

3.

KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors.

Black, Joshua C; Manning, Amity L; Van Rechem, Capucine; Kim, Jaegil; Ladd, Brendon; Cho, Juok; Pineda, Cristiana M; Murphy, Nancy; Daniels, Danette L; Montagna, Cristina; Lewis, Peter W; Glass, Kimberly; Allis, C David; Dyson, Nicholas J; Getz, Gad; Whetstine, Johnathan R.

Cell ; 154(3): 541-55, 2013 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-23871696

4.

A Code of Mono-phosphorylation Modulates the Function of RB.

Sanidas, Ioannis; Morris, Robert; Fella, Katerina A; Rumde, Purva H; Boukhali, Myriam; Tai, Eric C; Ting, David T; Lawrence, Michael S; Haas, Wilhelm; Dyson, Nicholas J.

Mol Cell ; 73(5): 985-1000.e6, 2019 03 07.

Artigo em Inglês | MEDLINE | ID: mdl-30711375

5.

Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.

Kottakis, Filippos; Nicolay, Brandon N; Roumane, Ahlima; Karnik, Rahul; Gu, Hongcang; Nagle, Julia M; Boukhali, Myriam; Hayward, Michele C; Li, Yvonne Y; Chen, Ting; Liesa, Marc; Hammerman, Peter S; Wong, Kwok Kin; Hayes, D Neil; Shirihai, Orian S; Dyson, Nicholas J; Haas, Wilhelm; Meissner, Alexander; Bardeesy, Nabeel.

Nature ; 575(7783): E5, 2019 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-31695192

6.

Lead compound profiling for small molecule inhibitors of the REV1-CT/RIR Translesion synthesis Protein-Protein interaction.

Zaino, Angela M; Dash, Radha Charan; James, Stephy J; MacGilvary, Nathan; Crompton, Andrew; McPherson, Kerry S; Stanzione, Marcello; Korzhnev, Dmitry M; Dyson, Nicholas J; Chatterjee, Nimrat; Cantor, Sharon B; Hadden, M Kyle.

Bioorg Med Chem ; 106: 117755, 2024 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-38749343

7.

pRB Takes an EZ Path to a Repetitive Task.

Sanidas, Ioannis; Dyson, Nicholas J.

Mol Cell ; 64(6): 1015-1017, 2016 12 15.

Artigo em Inglês | MEDLINE | ID: mdl-27984740

8.

RB1: a prototype tumor suppressor and an enigma.

Dyson, Nicholas J.

Genes Dev ; 30(13): 1492-502, 2016 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-27401552

9.

The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival.

Wang, Haizhen; Nicolay, Brandon N; Chick, Joel M; Gao, Xueliang; Geng, Yan; Ren, Hong; Gao, Hui; Yang, Guizhi; Williams, Juliet A; Suski, Jan M; Keibler, Mark A; Sicinska, Ewa; Gerdemann, Ulrike; Haining, W Nicholas; Roberts, Thomas M; Polyak, Kornelia; Gygi, Steven P; Dyson, Nicholas J; Sicinski, Piotr.

Nature ; 546(7658): 426-430, 2017 06 15.

Artigo em Inglês | MEDLINE | ID: mdl-28607489

10.

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation.

Nicolay, Brandon N; Danielian, Paul S; Kottakis, Filippos; Lapek, John D; Sanidas, Ioannis; Miles, Wayne O; Dehnad, Mantre; Tschöp, Katrin; Gierut, Jessica J; Manning, Amity L; Morris, Robert; Haigis, Kevin; Bardeesy, Nabeel; Lees, Jacqueline A; Haas, Wilhelm; Dyson, Nicholas J.

Genes Dev ; 29(17): 1875-89, 2015 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-26314710

11.

LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.

Kottakis, Filippos; Nicolay, Brandon N; Roumane, Ahlima; Karnik, Rahul; Gu, Hongcang; Nagle, Julia M; Boukhali, Myriam; Hayward, Michele C; Li, Yvonne Y; Chen, Ting; Liesa, Marc; Hammerman, Peter S; Wong, Kwok Kin; Hayes, D Neil; Shirihai, Orian S; Dyson, Nicholas J; Haas, Wilhelm; Meissner, Alexander; Bardeesy, Nabeel.

Nature ; 539(7629): 390-395, 2016 11 17.

Artigo em Inglês | MEDLINE | ID: mdl-27799657

12.

Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion.

Manning, Amity L; Yazinski, Stephanie A; Nicolay, Brandon; Bryll, Alysia; Zou, Lee; Dyson, Nicholas J.

Mol Cell ; 53(6): 993-1004, 2014 Mar 20.

Artigo em Inglês | MEDLINE | ID: mdl-24613344

13.

Clinical Outcomes With Abemaciclib After Prior CDK4/6 Inhibitor Progression in Breast Cancer: A Multicenter Experience.

Wander, Seth A; Han, Hyo S; Zangardi, Mark L; Niemierko, Andrzej; Mariotti, Veronica; Kim, Leslie S L; Xi, Jing; Pandey, Apurva; Dunne, Siobhan; Nasrazadani, Azadeh; Kambadakone, Avinash; Stein, Casey; Lloyd, Maxwell R; Yuen, Megan; Spring, Laura M; Juric, Dejan; Kuter, Irene; Sanidas, Ioannis; Moy, Beverly; Mulvey, Therese; Vidula, Neelima; Dyson, Nicholas J; Ellisen, Leif W; Isakoff, Steven; Wagle, Nikhil; Brufsky, Adam; Kalinsky, Kevin; Ma, Cynthia X; O'Shaughnessy, Joyce; Bardia, Aditya.

J Natl Compr Canc Netw ; : 1-8, 2021 Mar 24.

Artigo em Inglês | MEDLINE | ID: mdl-33761455

14.

Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.

Perera, Rushika M; Stoykova, Svetlana; Nicolay, Brandon N; Ross, Kenneth N; Fitamant, Julien; Boukhali, Myriam; Lengrand, Justine; Deshpande, Vikram; Selig, Martin K; Ferrone, Cristina R; Settleman, Jeff; Stephanopoulos, Gregory; Dyson, Nicholas J; Zoncu, Roberto; Ramaswamy, Sridhar; Haas, Wilhelm; Bardeesy, Nabeel.

Nature ; 524(7565): 361-5, 2015 Aug 20.

Artigo em Inglês | MEDLINE | ID: mdl-26168401

15.

Loss of RBF1 changes glutamine catabolism.

Nicolay, Brandon N; Gameiro, Paulo A; Tschöp, Katrin; Korenjak, Michael; Heilmann, Andreas M; Asara, John M; Stephanopoulos, Gregory; Iliopoulos, Othon; Dyson, Nicholas J.

Genes Dev ; 27(2): 182-96, 2013 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-23322302

16.

Conserved functions of the pRB and E2F families.

van den Heuvel, Sander; Dyson, Nicholas J.

Nat Rev Mol Cell Biol ; 9(9): 713-24, 2008 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-18719710

17.

Phosphorylation puts the pRb tumor suppressor into shape.

Heilmann, Andreas M F; Dyson, Nicholas J.

Genes Dev ; 26(11): 1128-30, 2012 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-22661226

18.

Pumilio facilitates miRNA regulation of the E2F3 oncogene.

Miles, Wayne O; Tschöp, Katrin; Herr, Anabel; Ji, Jun-Yuan; Dyson, Nicholas J.

Genes Dev ; 26(4): 356-68, 2012 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-22345517

19.

A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development.

Mulligan, Peter; Yang, Fajun; Di Stefano, Luisa; Ji, Jun-Yuan; Ouyang, Jian; Nishikawa, Joy L; Toiber, Debra; Kulkarni, Madhura; Wang, Qun; Najafi-Shoushtari, S Hani; Mostoslavsky, Raul; Gygi, Steven P; Gill, Grace; Dyson, Nicholas J; Näär, Anders M.

Mol Cell ; 42(5): 689-99, 2011 Jun 10.

Artigo em Inglês | MEDLINE | ID: mdl-21596603

20.

Functional antagonism between histone H3K4 demethylases in vivo.

Di Stefano, Luisa; Walker, James A; Burgio, Giosalba; Corona, Davide F V; Mulligan, Peter; Näär, Anders M; Dyson, Nicholas J.

Genes Dev ; 25(1): 17-28, 2011 Jan 01.

Artigo em Inglês | MEDLINE | ID: mdl-21205864

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