Detalhe da pesquisa
1.
Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.
Bioorg Med Chem Lett
; 27(9): 2069-2073, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284804
2.
Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus.
Bioorg Med Chem Lett
; 27(9): 2063-2068, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284809
3.
Quantifying rates of glucose production in vivo following an intraperitoneal tracer bolus.
Am J Physiol Endocrinol Metab
; 311(6): E911-E921, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27651111
4.
The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors.
Bioorg Med Chem Lett
; 26(11): 2622-6, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27106708
5.
SAR exploration at the C-3 position of tetrahydro-ß-carboline sstr3 antagonists.
Bioorg Med Chem Lett
; 26(6): 1529-1535, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26898814
6.
Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin.
Bioorg Med Chem Lett
; 25(24): 5767-71, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26546218
7.
The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets.
J Pharmacol Exp Ther
; 344(2): 407-16, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23161216
8.
Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2- (2,5-difluorophenyl)-5-(4,6-dihydropyrrolo [3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23) [corrected].
Bioorg Med Chem Lett
; 23(19): 5361-6, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23972441
9.
A PEGylated analog of the gut hormone oxyntomodulin with long-lasting antihyperglycemic, insulinotropic and anorexigenic activity.
Bioorg Med Chem
; 21(22): 7064-73, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24094437
10.
Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia.
J Lipid Res
; 53(1): 51-65, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22021650
11.
Differential effects of oxyntomodulin and GLP-1 on glucose metabolism.
Am J Physiol Endocrinol Metab
; 303(2): E265-71, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22621866
12.
3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists.
Bioorg Med Chem Lett
; 21(11): 3390-4, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21514824
13.
Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists.
Bioorg Med Chem Lett
; 20(3): 1298-301, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20064714
14.
Genetic ablation or pharmacological blockade of dipeptidyl peptidase IV does not impact T cell-dependent immune responses.
BMC Immunol
; 10: 19, 2009 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-19358731
15.
Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors.
Bioorg Med Chem Lett
; 19(15): 4097-101, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19539471
16.
Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines.
J Med Chem
; 51(3): 589-602, 2008 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18201067
17.
An automated electrophysiology serum shift assay for K(V) channels.
Assay Drug Dev Technol
; 6(2): 243-53, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18471078
18.
A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice.
Endocrinol Diabetes Metab
; 1(1): e00002, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-30815539
19.
Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy.
Science
; 357(6350): 507-511, 2017 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28705990
20.
Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.
Diabetes
; 54(10): 2988-94, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16186403