Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

The expanding amyloid family: Structure, stability, function, and pathogenesis.

Sawaya, Michael R; Hughes, Michael P; Rodriguez, Jose A; Riek, Roland; Eisenberg, David S.

Cell ; 184(19): 4857-4873, 2021 09 16.

Artigo em Inglês | MEDLINE | ID: mdl-34534463

2.

Structural Studies of Amyloid Proteins at the Molecular Level.

Eisenberg, David S; Sawaya, Michael R.

Annu Rev Biochem ; 86: 69-95, 2017 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-28125289

3.

How Hard It Is Seeing What Is in Front of Your Eyes.

Eisenberg, David S.

Cell ; 174(1): 8-11, 2018 06 28.

Artigo em Inglês | MEDLINE | ID: mdl-29958112

4.

Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.

Jiang, Yi Xiao; Cao, Qin; Sawaya, Michael R; Abskharon, Romany; Ge, Peng; DeTure, Michael; Dickson, Dennis W; Fu, Janine Y; Ogorzalek Loo, Rachel R; Loo, Joseph A; Eisenberg, David S.

Nature ; 605(7909): 304-309, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35344984

5.

Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils.

Murray, Kevin A; Hu, Carolyn J; Pan, Hope; Lu, Jiahui; Abskharon, Romany; Bowler, Jeannette T; Rosenberg, Gregory M; Williams, Christopher K; Elezi, Gazmend; Balbirnie, Melinda; Faull, Kym F; Vinters, Harry V; Seidler, Paul M; Eisenberg, David S.

Proc Natl Acad Sci U S A ; 120(7): e2217835120, 2023 02 14.

Artigo em Inglês | MEDLINE | ID: mdl-36757890

6.

Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.

Abskharon, Romany; Pan, Hope; Sawaya, Michael R; Seidler, Paul M; Olivares, Eileen J; Chen, Yu; Murray, Kevin A; Zhang, Jeffrey; Lantz, Carter; Bentzel, Megan; Boyer, David R; Cascio, Duilio; Nguyen, Binh A; Hou, Ke; Cheng, Xinyi; Pardon, Els; Williams, Christopher K; Nana, Alissa L; Vinters, Harry V; Spina, Salvatore; Grinberg, Lea T; Seeley, William W; Steyaert, Jan; Glabe, Charles G; Ogorzalek Loo, Rachel R; Loo, Joseph A; Eisenberg, David S.

Proc Natl Acad Sci U S A ; 120(41): e2300258120, 2023 10 10.

Artigo em Inglês | MEDLINE | ID: mdl-37801475

7.

Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.

Lu, Jiahui; Ge, Peng; Sawaya, Michael R; Hughes, Michael P; Boyer, David R; Cao, Qin; Abskharon, Romany; Cascio, Duilio; Tayeb-Fligelman, Einav; Eisenberg, David S.

J Biol Chem ; 300(2): 105531, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38072051

8.

Propagation of Tau Aggregates and Neurodegeneration.

Goedert, Michel; Eisenberg, David S; Crowther, R Anthony.

Annu Rev Neurosci ; 40: 189-210, 2017 07 25.

Artigo em Inglês | MEDLINE | ID: mdl-28772101

9.

Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation.

Abskharon, Romany; Sawaya, Michael R; Boyer, David R; Cao, Qin; Nguyen, Binh A; Cascio, Duilio; Eisenberg, David S.

Proc Natl Acad Sci U S A ; 119(15): e2119952119, 2022 04 12.

Artigo em Inglês | MEDLINE | ID: mdl-35377792

10.

De novo designed protein inhibitors of amyloid aggregation and seeding.

Murray, Kevin A; Hu, Carolyn J; Griner, Sarah L; Pan, Hope; Bowler, Jeannette T; Abskharon, Romany; Rosenberg, Gregory M; Cheng, Xinyi; Seidler, Paul M; Eisenberg, David S.

Proc Natl Acad Sci U S A ; 119(34): e2206240119, 2022 08 23.

Artigo em Inglês | MEDLINE | ID: mdl-35969734

11.

TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.

Vogler, Thomas O; Wheeler, Joshua R; Nguyen, Eric D; Hughes, Michael P; Britson, Kyla A; Lester, Evan; Rao, Bhalchandra; Betta, Nicole Dalla; Whitney, Oscar N; Ewachiw, Theodore E; Gomes, Edward; Shorter, James; Lloyd, Thomas E; Eisenberg, David S; Taylor, J Paul; Johnson, Aaron M; Olwin, Bradley B; Parker, Roy.

Nature ; 563(7732): 508-513, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30464263

12.

Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like ß-sheets.

Bowler, Jeannette T; Sawaya, Michael R; Boyer, David R; Cascio, Duilio; Bali, Manya; Eisenberg, David S.

J Biol Chem ; 298(10): 102396, 2022 10.

Artigo em Inglês | MEDLINE | ID: mdl-35988647

13.

Bioinformatic identification of previously unrecognized amyloidogenic proteins.

Rosenberg, Gregory M; Murray, Kevin A; Salwinski, Lukasz; Hughes, Michael P; Abskharon, Romany; Eisenberg, David S.

J Biol Chem ; 298(5): 101920, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35405097

14.

Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation.

Soragni, Alice; Yousefi, Shida; Stoeckle, Christina; Soriaga, Angela B; Sawaya, Michael R; Kozlowski, Evelyne; Schmid, Inès; Radonjic-Hoesli, Susanne; Boutet, Sebastien; Williams, Garth J; Messerschmidt, Marc; Seibert, M Marvin; Cascio, Duilio; Zatsepin, Nadia A; Burghammer, Manfred; Riekel, Christian; Colletier, Jacques-Philippe; Riek, Roland; Eisenberg, David S; Simon, Hans-Uwe.

Mol Cell ; 57(6): 1011-1021, 2015 Mar 19.

Artigo em Inglês | MEDLINE | ID: mdl-25728769

15.

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.

Boyer, David R; Li, Binsen; Sun, Chuanqi; Fan, Weijia; Zhou, Kang; Hughes, Michael P; Sawaya, Michael R; Jiang, Lin; Eisenberg, David S.

Proc Natl Acad Sci U S A ; 117(7): 3592-3602, 2020 02 18.

Artigo em Inglês | MEDLINE | ID: mdl-32015135

16.

Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils.

Hughes, Michael P; Goldschmidt, Lukasz; Eisenberg, David S.

J Biol Chem ; 297(4): 101194, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34537246

17.

The activities of amyloids from a structural perspective.

Riek, Roland; Eisenberg, David S.

Nature ; 539(7628): 227-235, 2016 11 10.

Artigo em Inglês | MEDLINE | ID: mdl-27830791

18.

De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure.

Colletier, Jacques-Philippe; Sawaya, Michael R; Gingery, Mari; Rodriguez, Jose A; Cascio, Duilio; Brewster, Aaron S; Michels-Clark, Tara; Hice, Robert H; Coquelle, Nicolas; Boutet, Sébastien; Williams, Garth J; Messerschmidt, Marc; DePonte, Daniel P; Sierra, Raymond G; Laksmono, Hartawan; Koglin, Jason E; Hunter, Mark S; Park, Hyun-Woo; Uervirojnangkoorn, Monarin; Bideshi, Dennis K; Brunger, Axel T; Federici, Brian A; Sauter, Nicholas K; Eisenberg, David S.

Nature ; 539(7627): 43-47, 2016 11 03.

Artigo em Inglês | MEDLINE | ID: mdl-27680699

19.

Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.

Abskharon, Romany; Seidler, Paul M; Sawaya, Michael R; Cascio, Duilio; Yang, Tianxiao P; Philipp, Stephan; Williams, Christopher Kazu; Newell, Kathy L; Ghetti, Bernardino; DeTure, Michael A; Dickson, Dennis W; Vinters, Harry V; Felgner, Philip L; Nakajima, Rie; Glabe, Charles G; Eisenberg, David S.

J Biol Chem ; 295(31): 10662-10676, 2020 07 31.

Artigo em Inglês | MEDLINE | ID: mdl-32493775

20.

Structure of the toxic core of α-synuclein from invisible crystals.

Rodriguez, Jose A; Ivanova, Magdalena I; Sawaya, Michael R; Cascio, Duilio; Reyes, Francis E; Shi, Dan; Sangwan, Smriti; Guenther, Elizabeth L; Johnson, Lisa M; Zhang, Meng; Jiang, Lin; Arbing, Mark A; Nannenga, Brent L; Hattne, Johan; Whitelegge, Julian; Brewster, Aaron S; Messerschmidt, Marc; Boutet, Sébastien; Sauter, Nicholas K; Gonen, Tamir; Eisenberg, David S.

Nature ; 525(7570): 486-90, 2015 Sep 24.

Artigo em Inglês | MEDLINE | ID: mdl-26352473

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