LOCCATE: A tool to identify the diagnostic spectrum profile of motor function and functional communication responses for the individual with a prolonged disorder of consciousness.

Standardized neurobehavioural assessment tools (SNBATs) form a key aspect of diagnostic assessment for individuals with prolonged disorders of consciousness (PDOCs). Each SNBAT has different psychometric properties, operational definitions of behaviours, scoring systems and methods of administration. Selection and implementation of SNBATs varies within and between healthcare settings. Defining diagnostic and prognostic parameters requires collating multiple SNBAT results over time, which is problematic if several assessors and professions are involved. The Levels of Consciousness Calibration of Assessment Tools Evaluations (LOCCATE) is the first tool designed to calibrate the results of any recognized PDOC SNBAT. It also categorizes the diagnostic spectrum profile of both motor and communication responses into eight criteria of behaviours. Each criterion has up to three levels of reproducibility, ultimately producing a LOCCATE calibration score ranging from 1 to 27. A case study is presented to illustrate changes in LOCCATE scores over time, while an audit explores the tool's clinical utility. With current directives placing less emphasis on a PDOC diagnosis, there is now a greater need for a calibration tool such as LOCCATE to identify exactly what the individual can do and create an accurate trajectory as an evidence base to support clinical and best-interest decision-making.

Primary amebic meningoencephalitis in Florida: a case report and epidemiological review of Florida cases.

Primary amebic meningoencephalitis (PAM) is a rare but nearly always fatal infection of the central nervous system caused by the thermophilic, free-living ameba Naegleria fowleri. Since its first description in 1965 through 2010, 118 cases have been reported in the U.S.; all cases are related to environmental exposure to warm freshwater; most have occurred in children and adolescents and are associated with recreational water activities, such as swimming, diving, or playing in freshwater lakes, ponds, or rivers. Over one-fourth of all national PAM cases have occurred in Florida. The authors describe here a fatal case of PAM in a resident of northeast Florida and the ensuing environmental and public health investigation; they also provide a review of all cases of PAM in Florida from 1962 to 2010 and discuss public health responses to PAM in Florida, highlighting opportunities for positive collaboration between state and local environmental health specialists, epidemiologists, and the Centers for Disease Control and Prevention.