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1.
BMC Anesthesiol ; 24(1): 140, 2024 Apr 12.
Artigo em Inglês | MEDLINE | ID: mdl-38609864

RESUMO

BACKGROUND: Aneurysmal subarachnoid hemorrhage (aSAH) is preferentially treated by prompt endovascular coiling, which is not available in Guadeloupe. Subsequently, patients are transferred to Paris, France mainland, by commercial airplane (6751 km flight) after being managed according to guidelines. This study describes the characteristics, management and outcomes related to these patients. METHODS: Retrospective observational cohort study of 148 patients admitted in intensive care unit for a suspected aSAH and transferred by airplane over a 10-year period (2010-2019). RESULTS: The median [interquartile range] age was 53 [45-64] years and 61% were female. On admission, Glasgow coma scale was 15 [13-15], World Federation of Neurological Surgeons (WFNS) grading scale was 1 [1-3] and Fisher scale was 4 [2-4]. External ventricular drainage and mechanical ventilation were performed prior to the flight respectively in 42% and 47% of patients. One-year mortality was 16% over the study period. By COX logistic regression analysis, acute hydrocephalus (hazard ratio [HR] 2.34, 95% confidence interval [CI] 0.98-5.58) prior to airplane transfer, WFNS grading scale on admission (HR 1.53, 95% CI 1.16-2.02) and age (OR 1.03, 95% 1.00-1.07) were associated with one-year mortality. CONCLUSION: When necessary, transatlantic air transfer of patients with suspected aSAH after management according to local guidelines seems feasible and safe.


Assuntos
Hemorragia Subaracnóidea , Humanos , Feminino , Pessoa de Meia-Idade , Masculino , Estudos Retrospectivos , Hemorragia Subaracnóidea/cirurgia , Aeronaves , Drenagem , França
2.
J Neurophysiol ; 125(5): 1982-1986, 2021 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-33881921

RESUMO

This case study aimed at monitoring ictal vasodilation in a clinical setting to confirm the experimental data on enhanced cerebral perfusion during epileptic seizures. Clinical observation of a patient presenting relapsing seizures in the intensive care unit. Transcranial Doppler (TCD) was used to monitor both blood velocities and the arterial caliber in the B-flow mode as a proxy of blood flow of the middle cerebral artery (MCA). A 35-yr-old woman experienced partial epileptic seizures lasting for 1 min that recurred every 5 min. Seizures were monitored with continuous EEG and TCD. During the seizure, the MCA caliber increased whereas velocities remained stable, which doubled the MCA blood flow. Immediately after the seizure, the artery caliber returned to its initial value, and the velocities increased by one-third of the initial value. After intensification of antiepileptic treatment, clinical seizures ceased, and TCD findings returned to normal MCA caliber and velocities. Autoimmune encephalitis was identified by brain biopsy and the patient recovered with corticosteroids treatment. This is the first description of ictal vasodilatation assessed by TCD. Our current understanding holds that cerebral blood flow increases during a seizure, but our report demonstrates that arterial dilation preceded the acceleration of velocities. This case study in a clinical setting confirms the impact of seizures on cerebral blood flow. NEW & NOTEWORTHY The case study is a clinical demonstration of ictal vasodilation. By assessing arterial caliber and blood velocities with transcranial Doppler, we dissected the impact of seizures on blood flow of the middle cerebral artery in the following sequence: 1) vasodilation occurred, concomitant to the epileptic activity, whereas the blood velocities remained stable and 2) immediately after the seizure, the velocities increased and the artery caliber returned to its initial value. As per author, there was no protocol, but one patient gave consent to use data from her medical file.


Assuntos
Circulação Cerebrovascular , Convulsões/diagnóstico por imagem , Ultrassonografia Doppler Transcraniana , Vasodilatação/fisiologia , Adulto , Circulação Cerebrovascular/fisiologia , Eletroencefalografia , Feminino , Humanos , Artéria Cerebral Média/diagnóstico por imagem
3.
Crit Care ; 24(1): 528, 2020 08 28.
Artigo em Inglês | MEDLINE | ID: mdl-32859261

RESUMO

An amendment to this paper has been published and can be accessed via the original article.

4.
Neurocrit Care ; 31(2): 338-345, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-30877554

RESUMO

INTRODUCTION: Transcranial Doppler (TCD) of the middle cerebral artery (MCA) enables the measurement of the mean blood velocity (MCAVm) and the estimation of the cerebral blood flow (CBF), provided that no significant changes occur in the MCA diameter (MCADiam). Previous studies described a decrease in the MCAVm associated with the induction of total intravenous anesthesia (TIVA) by propofol and remifentanil. This decrease in blood velocity might be interpreted as a decrease in the CBF only where the MCADiam is not modified across TCD examinations. METHODS: In this observational study, we measured the MCADiam of 24 subjects (almost exclusively females) on digital subtraction angiography under awake and TIVA conditions. RESULTS: Across the two phases, we observed a decrease in the mean arterial blood pressure (from 84 ± 9 to 71 ± 6 mmHg; p < 0.001) and heart rate (76 ± 10 vs. 65 ± 8 beats/min; p < 0.001), and a concomitant decrease in the MCAVm (61 vs. 42 cm/s; p < 0.001). In contrast, the MCADiam did not vary in association with TIVA (2.3 ± 0.2 vs. 2.3 ± 0.2 mm; p = 0.52). CONCLUSIONS: Those results suggested that in this population, no significant changes in the MCADiam are associated with TIVA.


Assuntos
Analgésicos Opioides/uso terapêutico , Anestesia Geral , Anestésicos Intravenosos/uso terapêutico , Angiografia Digital , Artéria Cerebral Média/diagnóstico por imagem , Propofol/uso terapêutico , Remifentanil/uso terapêutico , Ultrassonografia Doppler Transcraniana , Adulto , Velocidade do Fluxo Sanguíneo , Angiografia Cerebral , Circulação Cerebrovascular , Feminino , Hemodinâmica , Humanos , Masculino , Pessoa de Meia-Idade , Artéria Cerebral Média/anatomia & histologia , Tamanho do Órgão , Radiologia Intervencionista , Estudos Retrospectivos , Stents , Seios Transversos
6.
Am J Respir Crit Care Med ; 195(4): 491-499, 2017 02 15.
Artigo em Inglês | MEDLINE | ID: mdl-27552490

RESUMO

RATIONALE: Encephalitis caused by anti-N-methyl-d-aspartate receptor (NMDAR) antibodies is the leading cause of immune-mediated encephalitis. There are limited data on intensive care unit (ICU) management of these patients. OBJECTIVES: To identify prognostic factors of good neurologic outcome in patients admitted to an ICU with anti-NMDAR encephalitis. METHODS: This was an observational multicenter study of all consecutive adult patients diagnosed with anti-NMDAR encephalitis at the French National Reference Centre, admitted to an ICU between 2008 and 2014. The primary outcome was a good neurologic outcome at 6 months after ICU admission, defined by a modified Rankin Scale score of 0-2. MEASUREMENTS AND MAIN RESULTS: Seventy-seven patients were included from 52 ICUs. First-line immunotherapy consisted of steroids (n = 61/74; 82%), intravenous immunoglobulins (n = 71/74; 96%), and plasmapheresis (n = 17/74; 23%). Forty-five (61%) patients received second-line immunotherapy (cyclophosphamide, rituximab, or both). At 6 months, 57% of patients had a good neurologic outcome. Independent factors of good neurologic outcome were early (≤8 d after ICU admission) immunotherapy (odds ratio, 16.16; 95% confidence interval, 3.32-78.64; for combined first-line immunotherapy with steroids and intravenous immunoglobulins vs. late immunotherapy), and a low white blood cell count on the first cerebrospinal examination (odds ratio, 9.83 for <5 vs. >50 cells/mm3; 95% confidence interval, 1.07-90.65). Presence of nonneurologic organ failures at ICU admission and occurrence of status epilepticus during ICU stay were not associated with neurologic outcome. CONCLUSIONS: The prognosis of adult patients with anti-NMDAR encephalitis requiring intensive care is good, especially when immunotherapy is initiated early, advocating for prompt diagnosis and early aggressive treatment.


Assuntos
Encefalite Antirreceptor de N-Metil-D-Aspartato/imunologia , Encéfalo/fisiopatologia , Imunoglobulinas/uso terapêutico , Esteroides/uso terapêutico , Administração Intravenosa , Adulto , Distribuição por Idade , Análise de Variância , Encefalite Antirreceptor de N-Metil-D-Aspartato/líquido cefalorraquidiano , Encefalite Antirreceptor de N-Metil-D-Aspartato/terapia , Feminino , França , Humanos , Imunoglobulinas/administração & dosagem , Imunoterapia/métodos , Unidades de Terapia Intensiva , Masculino , Neuroimagem/métodos , Plasmaferese/métodos , Prognóstico , Receptores de N-Metil-D-Aspartato/imunologia , Estudos Retrospectivos , Prevenção Secundária , Distribuição por Sexo , Resultado do Tratamento , Adulto Jovem
13.
Artigo em Inglês | MEDLINE | ID: mdl-39051941

RESUMO

OBJECTIVE: It is recommended that ruptured cerebral aneurysms are treated in a high-volume center within 72 hours of ictus. We assessed the impact of long-distance aeromedical evacuation in patients presenting aSAH. METHODS: This case-control study compared patients with aneurysmal subarachnoid hemorrhage (aSAH) who had a 6750 km air transfer from Guadeloupe (a Caribbean island) to Paris, France, for neurointerventional management in a tertiary center with a matched cohort from Paris region treated in the same center over a 10-year period (2010 to 2019). The 2 populations were matched on age, sex, World Federation of Neurological Surgeons score, and Fisher score. The primary outcome was a 1-year modified Rankin Scale score ≤3. Secondary outcomes included time from diagnosis to securing aneurysm, 1-year mortality, and a cost analysis. RESULTS: Among 128 consecutive aSAH transferred from Guadeloupe, 93 were matched with 93 patients from the Paris area. The proportion of patients with 1-year modified Rankin Scale ≤3 (75% vs 82%, respectively; P= 0.5) and 1-year mortality (18% vs 14%, respectively; P= 0.2) was similar in the Guadeloupe and Paris groups. The median (interquartile range: Q1, Q3) time from diagnosis to securing the aneurysm was higher in the patients from Guadeloupe than those from Paris (48 [30, 63] h vs 23 [12, 24] h, respectively; P< 0.001). Guadeloupean patients received mechanical ventilation (58% vs 38%; P< 0.001) and external ventricular drainage (55% vs 39%; P= 0.005) more often than those from Paris. The additional cost of treating a Guadeloupe patient in Paris was estimated at 7580 Euros or 17% of the estimated cost in Guadeloupe. CONCLUSIONS: Long-distance aeromedical evacuation of patients with aSAH from Guadeloupe to Paris resulted in a 25-hour increase in time to aneurysm coiling embolization time but did not impact 1-year functional outcomes or mortality.

14.
Heliyon ; 10(14): e34629, 2024 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-39130407

RESUMO

Purpose: Varicella-zoster virus (VZV) can cause a wide range of neurological complications, including meningoencephalitis, upon reactivation. The objective of this report is to alert physicians of the possibility of VZV recurrence with meningoencephalitis occurring during hospitalization in an intensive care unit (ICU) setting. Material and methods: Clinical observation of one patient. Case report: A 65 years old man was admitted to the ICU for subarachnoid hemorrhage. Although the initial treatment plan proved successful, the patient experienced numerous, mainly septic, complications. After stabilization, neurological impairment was observed with spontaneous eye opening without contact and no motor response, apart from sedation. Cerebrospinal fluid (CSF) PCR assay was positive for VZV. Intravenous acyclovir was administered for 14 days. Neurological status gradually improved with the patient showing eye and mouth opening on request as well as recovery of basic speech with one-word responses. Quantitative PCR assays showed significant decrease of VZV. EEG improved after treatment to show clear reactivity, but the abnormalities at baseline were non-specific of VZV meningoencephalitis. No new focal lesion was identified on MRI that could be linked to VZV meningoencephalitis. The patient recovered from VZV meningoencephalitis, but he finally died 44 days later, following cardiac arrest, with no reactivation of VZV infection. Conclusion: VZV meningoencephalitis may occur during hospitalization, especially during prolonged ICU stay which may be due to reactivation associated with sepsis-induced immunosuppression. It might be underestimated as MRI and EEG seem poorly contributive to the diagnosis, so CSF PCR analysis is the cornerstone exploration.

15.
Front Neurol ; 15: 1308462, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38576535

RESUMO

Objectives: Spontaneous intracranial hypotension (SIH) is frequently complicated by subacute subdural hematoma (SDH) and more rarely by bilateral thalamic ischemia. Here, we report a case of SIH-related SDH treated with three epidural patches (EPs), with follow-up of the intracranial pressure and lumbar intrathecal pressure. Methods: A 46-year-old man presented bilateral thalamic ischemia, then a growing SDH. After failure of urgent surgical evacuation, he underwent three saline EPs, two dynamic myelography examinations and one digital subtraction angiography-phlebography examination. However, because of no dural tear and no obstacle to the venous drainage of the vein of Galen, no therapeutic procedure was available, and the patient died. Results: The case exhibited a progressive increase in the transmission of lumbar intrathecal pressure to intracranial pressure during the three EPs. The EPs may have successfully treated the SIH, but the patient did not recover consciousness because of irreversible damage to both thalami. Conclusion: Clinicians should be aware of the bilateral thalamic ischemia picture that may be the presenting sign of SIH. Moreover, the key problem in the pathophysiology of SIH seems to be intraspinal and intracranial volumes rather than pressures. Therefore, intracranial hypotension syndrome might actually be an intraspinal hypovolume syndrome.

16.
Anaesth Crit Care Pain Med ; 43(1): 101317, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38934930

RESUMO

INTRODUCTION: The situation in France is unique, having a legal framework for continuous and deep sedation (CDS). However, its use in intensive care units (ICU), combined with the withdrawal of life-sustaining therapies, still raises ethical issues, particularly its potential to hasten death. The legalization of assistance in dying, i.e., assisted suicide or euthanasia at the patient's request, is currently under discussion in France. The objectives of this national survey were first, to assess whether ICU professionals perceive CDS administered to ICU patients as a practice that hastens death, in addition to relieving unbearable suffering, and second, to assess ICU professionals' perceptions of assistance in dying. METHODS: A national survey with online questionnaires for ICU physicians and nursesaddressed through the French Society of Anesthesiology and Critical Care Medicine. RESULTS: A total of 956 ICU professionals responded to the survey (38% physicians and 62% nurses). Of these, 22% of physicians and 12% of nurses (p < 0.001) felt that the purpose of CDS was to hasten death. For 20% of physicians, CDS combined with terminal extubation was considered an assistance in dying. For 52% of ICU professionals, the current framework did not sufficiently cover the range of situations that occur in the ICU. A favorable opinion on the potential legalization of assistance in dying was observed in 83% of nurses and 71% of physicians (p < 0.001), with no preference between assisted suicide and euthanasia. CONCLUSION: Our findings highlight the tension between CDS and assisted suicide/euthanasia in the specific context of intensive care and suggest that ICU professionals would be supportive of a legislative evolution.


Assuntos
Atitude do Pessoal de Saúde , Cuidados Críticos , Sedação Profunda , Unidades de Terapia Intensiva , Suicídio Assistido , Humanos , França , Suicídio Assistido/legislação & jurisprudência , Suicídio Assistido/ética , Masculino , Feminino , Inquéritos e Questionários , Adulto , Pessoa de Meia-Idade , Médicos , Assistência Terminal/legislação & jurisprudência , Assistência Terminal/ética , Eutanásia/legislação & jurisprudência , Extubação , Enfermeiras e Enfermeiros
17.
Neurol Clin Pract ; 13(2): e200137, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-37064593

RESUMO

Objectives: Convexity spontaneous subacute subdural hematoma (CSSSH) frequently relapse after one or more surgical drainages. This may be due to spontaneous intracranial hypotension (SIH), for which the gold standard treatment is the epidural blood patch. In this study, we report 4 cases of refractory CSSSH treated with rescue epidural saline patch, although history and imaging studies showed no evidence of SIH. Methods: All 4 patients received a lumbar saline epidural rescue patch for consciousness impairment associated with refractory CSSSH, and one is particularly detailed. No patient had typical radiologic signs of SIH or, on the contrary, uncal herniation that could have indicated intracranial hypertension. Results: The Glasgow Coma Scale score improved significantly in the days after application of the epidural patch in 3 patients. All patients showed an improvement of the CT scan. Two patients underwent lumbar pressure measurement to confirm low values before the epidural injection, and for one, the intrathecal pressure profile during epidural patching is presented. Discussion: An epidural patch may be considered in managing CSSSH with no uncal herniation, even in the absence of signs of SIH on brain and spinal imaging. Whether it should be combined with surgical evacuation or used as first-line therapy remains to be determined.

18.
J Neurosurg Anesthesiol ; 35(4): 417-422, 2023 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-35543619

RESUMO

BACKGROUND: During the first wave of the coronavirus disease-2019 (COVID-19) pandemic, it was necessary to prepare for the possibility of triaging patients who could benefit from access to an intensive care unit (ICU). In our neuroscience institution, the challenge was to continue to manage usual neurological emergencies as well as the influx of COVID-19 patients. METHODS: We report the experience of an ethical consulting unit to support care clinical decisions during the first wave of the pandemic (March 16 to April 30, 2020). Three objective evaluation criteria were defined: 2 of these criteria, patient's factors and general disease severity (Simplified Acute Physiology Score II), were common to all patients, and the third was the specific severity of the disease (neurological for brain injury, respiratory for COVID-19). Given our scarce resources, we used a high probability of a 3-month modified Rankin Scale ≤3 as the criterion for further resuscitation and management. RESULTS: A total of 295 patients were admitted during the first pandemic wave; 111 with COVID-19 and 184 with neurological emergencies. The ethical unit's expertise was sought for 75 clinical situations in 56 patients (35 COVID-19 and 21 neurological). Decisions were as follows: 11% no limitation on care, 5% expectant care with reassessment (maximum therapy to assess possible progress pending decision), 67% partial limitation (no intensification of care or no transfer to ICU), and 17% limitation of curative care. At no time did a lack of availability of ICU beds require the ethical unit to advise against admission to the ICU. CONCLUSIONS: Our ethical consulting unit allowed for collegial ethical decision-making in line with international recommendations. This model could be easily transferred to other triage situations, provided it is adapted to the local context.


Assuntos
COVID-19 , Humanos , Pandemias , Emergências , Unidades de Terapia Intensiva , Hospitais
19.
Neurology ; 100(22): e2247-e2258, 2023 05 30.
Artigo em Inglês | MEDLINE | ID: mdl-37041081

RESUMO

BACKGROUND AND OBJECTIVES: To report the prevalence of acute encephalopathy and outcomes in patients with severe coronavirus disease 2019 (COVID-19) and to identify determinants of 90-day outcomes. METHODS: Data from adults with severe COVID-19 and acute encephalopathy were prospectively collected for patients requiring intensive care unit management in 31 university or university-affiliated intensive care units in 6 countries (France, United States, Colombia, Spain, Mexico, and Brazil) between March and September of 2020. Acute encephalopathy was defined, as recently recommended, as subsyndromal delirium or delirium or as a comatose state in case of severely decreased level of consciousness. Logistic multivariable regression was performed to identify factors associated with 90-day outcomes. A Glasgow Outcome Scale-Extended (GOS-E) score of 1-4 was considered a poor outcome (indicating death, vegetative state, or severe disability). RESULTS: Of 4,060 patients admitted with COVID-19, 374 (9.2%) experienced acute encephalopathy at or before the intensive care unit (ICU) admission. A total of 199/345 (57.7%) patients had a poor outcome at 90-day follow-up as evaluated by the GOS-E (29 patients were lost to follow-up). On multivariable analysis, age older than 70 years (odds ratio [OR] 4.01, 95% CI 2.25-7.15), presumed fatal comorbidity (OR 3.98, 95% CI 1.68-9.44), Glasgow coma scale score <9 before/at ICU admission (OR 2.20, 95% CI 1.22-3.98), vasopressor/inotrope support during ICU stay (OR 3.91, 95% CI 1.97-7.76), renal replacement therapy during ICU stay (OR 2.31, 95% CI 1.21-4.50), and CNS ischemic or hemorrhagic complications as acute encephalopathy etiology (OR 3.22, 95% CI 1.41-7.82) were independently associated with higher odds of poor 90-day outcome. Status epilepticus, posterior reversible encephalopathy syndrome, and reversible cerebral vasoconstriction syndrome were associated with lower odds of poor 90-day outcome (OR 0.15, 95% CI 0.03-0.83). DISCUSSION: In this observational study, we found a low prevalence of acute encephalopathy at ICU admission in patients with COVID-19. More than half of patients with COVID-19 presenting with acute encephalopathy had poor outcomes as evaluated by GOS-E. Determinants of poor 90-day outcome were dominated by older age, comorbidities, degree of impairment of consciousness before/at ICU admission, association with other organ failures, and acute encephalopathy etiology. TRIAL REGISTRATION INFORMATION: The study is registered with ClinicalTrials.gov, number NCT04320472.


Assuntos
COVID-19 , Delírio , Síndrome da Leucoencefalopatia Posterior , Adulto , Humanos , Idoso , COVID-19/complicações , Coma/epidemiologia , Estudos Prospectivos , Unidades de Terapia Intensiva
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