Detalhe da pesquisa
1.
Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications.
Int J Mol Sci
; 22(20)2021 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34681626
2.
Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens.
Arch Toxicol
; 94(8): 2899-2923, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32594184
3.
CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.
Proc Natl Acad Sci U S A
; 113(7): 1817-22, 2016 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26831064
4.
Wnt-mediated protein stabilization ensures proper mitotic microtubule assembly and chromosome segregation.
EMBO Rep
; 16(4): 490-9, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25656539
5.
New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens-a PARC project.
Front Toxicol
; 5: 1220998, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37492623
6.
The 4th dimension of in vitro systems - Time to level up.
Environ Int
; 164: 107256, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35472563
7.
Loss of the tumour-suppressor genes CHK2 and BRCA1 results in chromosomal instability.
Biochem Soc Trans
; 38(6): 1704-8, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21118151
8.
Biomedical Research Meets Toxicology: How In Vitro Chromosome Instability Methods Can Contribute to Carcinogenicity Prediction.
Cancer Res
; 80(8): 1626-1629, 2020 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32094300
9.
Restoring circadian synchrony in vitro facilitates physiological responses to environmental chemicals.
Environ Int
; 134: 105265, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31734582
10.
A phenotypic screen identifies microtubule plus end assembly regulators that can function in mitotic spindle orientation.
Cell Cycle
; 14(6): 827-37, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25590964
11.
Microtubule plus tips: A dynamic route to chromosomal instability.
Mol Cell Oncol
; 2(2): e960768, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-27308411
12.
Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells.
Nat Cell Biol
; 16(8): 779-91, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24976383
13.
Tumor suppressor CHK2: regulator of DNA damage response and mediator of chromosomal stability.
Clin Cancer Res
; 17(3): 401-5, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21088254
14.
Centromere localization of INCENP-Aurora B is sufficient to support spindle checkpoint function.
Cell Cycle
; 9(7): 1360-72, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20372054
15.
The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells.
Nat Cell Biol
; 12(5): 492-9, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20364141
16.
Pharmacologic abrogation of the mitotic spindle checkpoint by an indolocarbazole discovered by cellular screening efficiently kills cancer cells.
Cancer Res
; 69(9): 3874-83, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19366805
17.
Interaction of TACC3 and TSC2 at the nuclear envelope and mitotic structures.
Cell Cycle
; 9(7): 1233, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20404524