Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Myc Cooperates with Ras by Programming Inflammation and Immune Suppression.

Kortlever, Roderik M; Sodir, Nicole M; Wilson, Catherine H; Burkhart, Deborah L; Pellegrinet, Luca; Brown Swigart, Lamorna; Littlewood, Trevor D; Evan, Gerard I.

Cell ; 171(6): 1301-1315.e14, 2017 Nov 30.

Artigo em Inglês | MEDLINE | ID: mdl-29195074

2.

Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA.

Abbosh, Christopher; Frankell, Alexander M; Harrison, Thomas; Kisistok, Judit; Garnett, Aaron; Johnson, Laura; Veeriah, Selvaraju; Moreau, Mike; Chesh, Adrian; Chaunzwa, Tafadzwa L; Weiss, Jakob; Schroeder, Morgan R; Ward, Sophia; Grigoriadis, Kristiana; Shahpurwalla, Aamir; Litchfield, Kevin; Puttick, Clare; Biswas, Dhruva; Karasaki, Takahiro; Black, James R M; Martínez-Ruiz, Carlos; Bakir, Maise Al; Pich, Oriol; Watkins, Thomas B K; Lim, Emilia L; Huebner, Ariana; Moore, David A; Godin-Heymann, Nadia; L'Hernault, Anne; Bye, Hannah; Odell, Aaron; Roberts, Paula; Gomes, Fabio; Patel, Akshay J; Manzano, Elizabeth; Hiley, Crispin T; Carey, Nicolas; Riley, Joan; Cook, Daniel E; Hodgson, Darren; Stetson, Daniel; Barrett, J Carl; Kortlever, Roderik M; Evan, Gerard I; Hackshaw, Allan; Daber, Robert D; Shaw, Jacqui A; Aerts, Hugo J W L; Licon, Abel; Stahl, Josh.

Nature ; 616(7957): 553-562, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-37055640

3.

All things to all people.

Littlewood, Trevor D; Kreuzaler, Peter; Evan, Gerard I.

Cell ; 151(1): 11-3, 2012 Sep 28.

Artigo em Inglês | MEDLINE | ID: mdl-23021211

4.

Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma.

Hall, Zoe; Chiarugi, Davide; Charidemou, Evelina; Leslie, Jack; Scott, Emma; Pellegrinet, Luca; Allison, Michael; Mocciaro, Gabriele; Anstee, Quentin M; Evan, Gerard I; Hoare, Matthew; Vidal-Puig, Antonio; Oakley, Fiona; Vacca, Michele; Griffin, Julian L.

Hepatology ; 73(3): 1028-1044, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-32460431

5.

Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling.

Kreuzaler, Peter; Clarke, Matthew A; Brown, Elizabeth J; Wilson, Catherine H; Kortlever, Roderik M; Piterman, Nir; Littlewood, Trevor; Evan, Gerard I; Fisher, Jasmin.

Proc Natl Acad Sci U S A ; 116(44): 22399-22408, 2019 10 29.

Artigo em Inglês | MEDLINE | ID: mdl-31611367

6.

Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice.

Soucek, Laura; Whitfield, Jonathan R; Sodir, Nicole M; Massó-Vallés, Daniel; Serrano, Erika; Karnezis, Anthony N; Swigart, Lamorna Brown; Evan, Gerard I.

Genes Dev ; 27(5): 504-13, 2013 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-23475959

7.

Myc linked to dysregulation of cholesterol transport and storage in nonsmall cell lung cancer.

Hall, Zoe; Wilson, Catherine H; Burkhart, Deborah L; Ashmore, Tom; Evan, Gerard I; Griffin, Julian L.

J Lipid Res ; 61(11): 1390-1399, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32753459

8.

Endogenous Myc maintains the tumor microenvironment.

Sodir, Nicole M; Swigart, Lamorna Brown; Karnezis, Anthony N; Hanahan, Douglas; Evan, Gerard I; Soucek, Laura.

Genes Dev ; 25(9): 907-16, 2011 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-21478273

9.

Validation of MdmX as a therapeutic target for reactivating p53 in tumors.

Garcia, Daniel; Warr, Matthew R; Martins, Carla P; Brown Swigart, Lamorna; Passegué, Emmanuelle; Evan, Gerard I.

Genes Dev ; 25(16): 1746-57, 2011 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-21852537

10.

SOX2 Drives Bronchial Dysplasia in a Novel Organotypic Model of Early Human Squamous Lung Cancer.

Correia, Lúcia L; Johnson, Jo-Anne; McErlean, Peter; Bauer, Julien; Farah, Hassan; Rassl, Doris M; Rintoul, Robert C; Sethi, Tariq; Lavender, Paul; Rawlins, Emma L; Littlewood, Trevor D; Evan, Gerard I; McCaughan, Frank M.

Am J Respir Crit Care Med ; 195(11): 1494-1508, 2017 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-28199128

11.

Selective activation of p53-mediated tumour suppression in high-grade tumours.

Junttila, Melissa R; Karnezis, Anthony N; Garcia, Daniel; Madriles, Francesc; Kortlever, Roderik M; Rostker, Fanya; Brown Swigart, Lamorna; Pham, David M; Seo, Youngho; Evan, Gerard I; Martins, Carla P.

Nature ; 468(7323): 567-71, 2010 Nov 25.

Artigo em Inglês | MEDLINE | ID: mdl-21107427

12.

Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy.

Shchors, Ksenya; Persson, Anders I; Rostker, Fanya; Tihan, Tarik; Lyubynska, Natalya; Li, Nan; Swigart, Lamorna Brown; Berger, Mitchel S; Hanahan, Douglas; Weiss, William A; Evan, Gerard I.

Proc Natl Acad Sci U S A ; 110(16): E1480-9, 2013 Apr 16.

Artigo em Inglês | MEDLINE | ID: mdl-23542378

13.

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation.

Itahana, Koji; Mao, Hua; Jin, Aiwen; Itahana, Yoko; Clegg, Hilary V; Lindström, Mikael S; Bhat, Krishna P; Godfrey, Virginia L; Evan, Gerard I; Zhang, Yanping.

Cancer Cell ; 12(4): 355-66, 2007 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-17936560

14.

Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology.

Pello, Oscar M; De Pizzol, Maria; Mirolo, Massimiliano; Soucek, Laura; Zammataro, Luca; Amabile, Angelo; Doni, Andrea; Nebuloni, Manuela; Swigart, Lamorna B; Evan, Gerard I; Mantovani, Alberto; Locati, Massimo.

Blood ; 119(2): 411-21, 2012 Jan 12.

Artigo em Inglês | MEDLINE | ID: mdl-22067385

15.

Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors.

Soucek, Laura; Lawlor, Elizabeth R; Soto, Darya; Shchors, Ksenya; Swigart, Lamorna Brown; Evan, Gerard I.

Nat Med ; 13(10): 1211-8, 2007 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-17906636

16.

Can't kick that oncogene habit.

Evan, Gerard I.

Cancer Cell ; 10(5): 345-7, 2006 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-17097554

17.

Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

Ringshausen, Ingo; O'Shea, Clodagh C; Finch, Andrew J; Swigart, Lamorna Brown; Evan, Gerard I.

Cancer Cell ; 10(6): 501-14, 2006 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-17157790

18.

Bcl-xL gain of function and p19 ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms.

Finch, Andrew; Prescott, Julia; Shchors, Ksenya; Hunt, Abigail; Soucek, Laura; Dansen, Tobias B; Swigart, Lamorna Brown; Evan, Gerard I.

Cancer Cell ; 10(2): 113-20, 2006 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-16904610

19.

Modelling Myc inhibition as a cancer therapy.

Soucek, Laura; Whitfield, Jonathan; Martins, Carla P; Finch, Andrew J; Murphy, Daniel J; Sodir, Nicole M; Karnezis, Anthony N; Swigart, Lamorna Brown; Nasi, Sergio; Evan, Gerard I.

Nature ; 455(7213): 679-83, 2008 Oct 02.

Artigo em Inglês | MEDLINE | ID: mdl-18716624

20.

Temporal dissection of p53 function in vitro and in vivo.

Christophorou, Maria A; Martin-Zanca, Dionisio; Soucek, Laura; Lawlor, Elizabeth R; Brown-Swigart, Lamorna; Verschuren, Emmy W; Evan, Gerard I.

Nat Genet ; 37(7): 718-26, 2005 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-15924142

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