Detalhe da pesquisa
1.
Negishi cross-coupling enabled synthesis of novel NAD(+)-dependent DNA ligase inhibitors and SAR development.
Bioorg Med Chem Lett
; 25(22): 5172-7, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26463129
2.
Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa.
Bioorg Med Chem
; 22(19): 5392-409, 2014 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25155913
3.
Design of inhibitors of Helicobacter pylori glutamate racemase as selective antibacterial agents: incorporation of imidazoles onto a core pyrazolopyrimidinedione scaffold to improve bioavailabilty.
Bioorg Med Chem Lett
; 22(17): 5600-7, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22877632
4.
Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition.
J Med Chem
; 65(4): 3371-3387, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35113565
5.
Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity.
J Med Chem
; 65(9): 6903-6925, 2022 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35500229
6.
Exploring Left-Hand-Side substitutions in the benzoxazinone series of 4-amino-piperidine bacterial type IIa topoisomerase inhibitors.
Bioorg Med Chem Lett
; 21(18): 5432-5, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21782427
7.
High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.
J Med Chem
; 64(15): 11379-11394, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34337941
8.
Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening.
J Med Chem
; 64(10): 6730-6744, 2021 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33955740
9.
Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.
J Med Chem
; 64(1): 719-740, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33395287
10.
1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis.
J Med Chem
; 64(17): 12790-12807, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34414766
11.
Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors.
ACS Infect Dis
; 6(11): 3048-3063, 2020 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32966036
12.
Antibacterial Spiropyrimidinetriones with N-Linked Azole Substituents on a Benzisoxazole Scaffold Targeting DNA Gyrase.
J Med Chem
; 63(20): 11882-11901, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32914979
13.
Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure-Activity Relationship Studies, and Biological Assessment.
ACS Omega
; 5(12): 6967-6982, 2020 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32258933
14.
Exploring 8-benzyl pteridine-6,7-diones as inhibitors of glutamate racemase (MurI) in gram-positive bacteria.
Bioorg Med Chem Lett
; 18(23): 6100-3, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18947997
15.
Plasmodial Kinase Inhibitors: License to Cure?
J Med Chem
; 61(18): 8061-8077, 2018 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29771541
16.
Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.
J Med Chem
; 61(20): 9371-9385, 2018 10 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30256636
17.
Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria.
J Med Chem
; 61(13): 5692-5703, 2018 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29889526
18.
Novel substituted (pyridin-3-yl)phenyloxazolidinones: antibacterial agents with reduced activity against monoamine oxidase A and increased solubility.
J Med Chem
; 50(20): 4868-81, 2007 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17722903
19.
Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping.
ACS Infect Dis
; 2(7): 456-64, 2016 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27626097
20.
Identification of 4-substituted 1,2,3-triazoles as novel oxazolidinone antibacterial agents with reduced activity against monoamine oxidase A.
J Med Chem
; 48(2): 499-506, 2005 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-15658863