Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Designer proteins to trigger cell death.

Fairbrother, Wayne J; Ashkenazi, Avi.

Cell ; 157(7): 1506-8, 2014 Jun 19.

Artigo em Inglês | MEDLINE | ID: mdl-24949963

2.

Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling.

Goncharov, Tatiana; Hedayati, Stefanie; Mulvihill, Melinda M; Izrael-Tomasevic, Anita; Zobel, Kerry; Jeet, Surinder; Fedorova, Anna V; Eidenschenk, Celine; deVoss, Jason; Yu, Kebing; Shaw, Andrey S; Kirkpatrick, Donald S; Fairbrother, Wayne J; Deshayes, Kurt; Vucic, Domagoj.

Mol Cell ; 69(4): 551-565.e7, 2018 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-29452636

3.

Targeted degradation via direct 26S proteasome recruitment.

Bashore, Charlene; Prakash, Sumit; Johnson, Matthew C; Conrad, Ryan J; Kekessie, Ivy A; Scales, Suzie J; Ishisoko, Noriko; Kleinheinz, Tracy; Liu, Peter S; Popovych, Nataliya; Wecksler, Aaron T; Zhou, Lijuan; Tam, Christine; Zilberleyb, Inna; Srinivasan, Rajini; Blake, Robert A; Song, Aimin; Staben, Steven T; Zhang, Yingnan; Arnott, David; Fairbrother, Wayne J; Foster, Scott A; Wertz, Ingrid E; Ciferri, Claudio; Dueber, Erin C.

Nat Chem Biol ; 19(1): 55-63, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-36577875

4.

Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein.

den Besten, Willem; Verma, Kshitij; Yamazoe, Sayumi; Blaquiere, Nicole; Phung, Wilson; Izrael-Tomasevic, Anita; Mulvihill, Melinda M; Helgason, Elizabeth; Prakash, Sumit; Goncharov, Tatiana; Vucic, Domagoj; Dueber, Erin; Fairbrother, Wayne J; Wertz, Ingrid; Yu, Kebing; Staben, Steven T.

J Am Chem Soc ; 143(28): 10571-10575, 2021 07 21.

Artigo em Inglês | MEDLINE | ID: mdl-34236858

5.

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.

Wertz, Ingrid E; Newton, Kim; Seshasayee, Dhaya; Kusam, Saritha; Lam, Cynthia; Zhang, Juan; Popovych, Nataliya; Helgason, Elizabeth; Schoeffler, Allyn; Jeet, Surinder; Ramamoorthi, Nandhini; Kategaya, Lorna; Newman, Robert J; Horikawa, Keisuke; Dugger, Debra; Sandoval, Wendy; Mukund, Susmith; Zindal, Anuradha; Martin, Flavius; Quan, Clifford; Tom, Jeffrey; Fairbrother, Wayne J; Townsend, Michael; Warming, Søren; DeVoss, Jason; Liu, Jinfeng; Dueber, Erin; Caplazi, Patrick; Lee, Wyne P; Goodnow, Christopher C; Balazs, Mercedesz; Yu, Kebing; Kolumam, Ganesh; Dixit, Vishva M.

Nature ; 528(7582): 370-5, 2015 Dec 17.

Artigo em Inglês | MEDLINE | ID: mdl-26649818

6.

A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.

Nile, Aaron H; de Sousa E Melo, Felipe; Mukund, Susmith; Piskol, Robert; Hansen, Simon; Zhou, Lijuan; Zhang, Yingnan; Fu, Yue; Gogol, Emily B; Kömüves, László G; Modrusan, Zora; Angers, Stephane; Franke, Yvonne; Koth, Christopher; Fairbrother, Wayne J; Wang, Weiru; de Sauvage, Frederic J; Hannoush, Rami N.

Nat Chem Biol ; 14(6): 582-590, 2018 06.

Artigo em Inglês | MEDLINE | ID: mdl-29632413

7.

Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.

Nile, Aaron H; de Sousa E Melo, Felipe; Mukund, Susmith; Piskol, Robert; Hansen, Simon; Zhou, Lijuan; Zhang, Yingnan; Fu, Yue; Gogol, Emily B; Kömüves, László G; Modrusan, Zora; Angers, Stephane; Franke, Yvonne; Koth, Christopher; Fairbrother, Wayne J; Wang, Weiru; de Sauvage, Frederic J; Hannoush, Rami N.

Nat Chem Biol ; 14(9): 902, 2018 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-29728602

8.

Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.

Holliday, Michael J; Ferrao, Ryan; de Leon Boenig, Gladys; Estevez, Alberto; Helgason, Elizabeth; Rohou, Alexis; Dueber, Erin C; Fairbrother, Wayne J.

J Biol Chem ; 293(43): 16803-16817, 2018 10 26.

Artigo em Inglês | MEDLINE | ID: mdl-30206119

9.

BCL2 mutations do not confer adverse prognosis in follicular lymphoma patients treated with rituximab.

Huet, Sarah; Szafer-Glusman, Edith; Tesson, Bruno; Xerri, Luc; Fairbrother, Wayne J; Mukhyala, Kiran; Bolen, Chris; Punnoose, Elizabeth; Tonon, Laurie; Chassagne-Clément, Catherine; Feugier, Pierre; Viari, Alain; Jardin, Fabrice; Salles, Gilles; Sujobert, Pierre.

Am J Hematol ; 92(6): 515-519, 2017 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-28247997

10.

Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.

Wertz, Ingrid E; Newton, Kim; Seshasayee, Dhaya; Kusam, Saritha; Lam, Cynthia; Zhang, Juan; Popovych, Nataliya; Helgason, Elizabeth; Schoeffler, Allyn; Jeet, Surinder; Ramamoorthi, Nandhini; Kategaya, Lorna; Newman, Robert J; Horikawa, Keisuke; Dugger, Debra; Sandoval, Wendy; Mukund, Susmith; Zindal, Anuradha; Martin, Flavius; Quan, Clifford; Tom, Jeffrey; Fairbrother, Wayne J; Townsend, Michael; Warming, Søren; DeVoss, Jason; Liu, Jinfeng; Dueber, Erin; Caplazi, Patrick; Lee, Wyne P; Goodnow, Christopher C; Balazs, Mercedesz; Yu, Kebing; Kolumam, Ganesh; Dixit, Vishva M.

Nature ; 532(7599): 402, 2016 Apr 21.

Artigo em Inglês | MEDLINE | ID: mdl-26760210

11.

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

Wertz, Ingrid E; Kusam, Saritha; Lam, Cynthia; Okamoto, Toru; Sandoval, Wendy; Anderson, Daniel J; Helgason, Elizabeth; Ernst, James A; Eby, Mike; Liu, Jinfeng; Belmont, Lisa D; Kaminker, Josh S; O'Rourke, Karen M; Pujara, Kanan; Kohli, Pawan Bir; Johnson, Adam R; Chiu, Mark L; Lill, Jennie R; Jackson, Peter K; Fairbrother, Wayne J; Seshagiri, Somasekar; Ludlam, Mary J C; Leong, Kevin G; Dueber, Erin C; Maecker, Heather; Huang, David C S; Dixit, Vishva M.

Nature ; 471(7336): 110-4, 2011 Mar 03.

Artigo em Inglês | MEDLINE | ID: mdl-21368834

12.

Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling.

Phillips, Aaron H; Zhang, Yingnan; Cunningham, Christian N; Zhou, Lijuan; Forrest, William F; Liu, Peter S; Steffek, Micah; Lee, James; Tam, Christine; Helgason, Elizabeth; Murray, Jeremy M; Kirkpatrick, Donald S; Fairbrother, Wayne J; Corn, Jacob E.

Proc Natl Acad Sci U S A ; 110(28): 11379-84, 2013 Jul 09.

Artigo em Inglês | MEDLINE | ID: mdl-23801757

13.

Structure-guided design of a selective BCL-X(L) inhibitor.

Lessene, Guillaume; Czabotar, Peter E; Sleebs, Brad E; Zobel, Kerry; Lowes, Kym N; Adams, Jerry M; Baell, Jonathan B; Colman, Peter M; Deshayes, Kurt; Fairbrother, Wayne J; Flygare, John A; Gibbons, Paul; Kersten, Wilhelmus J A; Kulasegaram, Sanji; Moss, Rebecca M; Parisot, John P; Smith, Brian J; Street, Ian P; Yang, Hong; Huang, David C S; Watson, Keith G.

Nat Chem Biol ; 9(6): 390-7, 2013 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-23603658

14.

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.

Dynek, Jasmin N; Goncharov, Tatiana; Dueber, Erin C; Fedorova, Anna V; Izrael-Tomasevic, Anita; Phu, Lilian; Helgason, Elizabeth; Fairbrother, Wayne J; Deshayes, Kurt; Kirkpatrick, Donald S; Vucic, Domagoj.

EMBO J ; 29(24): 4198-209, 2010 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-21113135

15.

Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist.

Wong, Harvey; Gould, Stephen E; Budha, Nageshwar; Darbonne, Walter C; Kadel, Edward E; La, Hank; Alicke, Bruno; Halladay, Jason S; Erickson, Rebecca; Portera, Chia; Tolcher, Anthony W; Infante, Jeffery R; Mamounas, Michael; Flygare, John A; Hop, Cornelis E C A; Fairbrother, Wayne J.

Drug Metab Dispos ; 41(12): 2104-13, 2013 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-24041744

16.

Characterization of ML-IAP protein stability and physiological role in vivo.

Varfolomeev, Eugene; Moradi, Elham; Dynek, Jasmin N; Zha, Jiping; Fedorova, Anna V; Deshayes, Kurt; Fairbrother, Wayne J; Newton, Kim; Le Couter, Jennifer; Vucic, Domagoj.

Biochem J ; 447(3): 427-36, 2012 Nov 01.

Artigo em Inglês | MEDLINE | ID: mdl-22853455

17.

Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1.

Lobito, Adrian A; Ramani, Sree R; Tom, Irene; Bazan, J Fernando; Luis, Elizabeth; Fairbrother, Wayne J; Ouyang, Wenjun; Gonzalez, Lino C.

J Biol Chem ; 286(21): 18969-81, 2011 May 27.

Artigo em Inglês | MEDLINE | ID: mdl-21454693

18.

Structure of C3b in complex with CRIg gives insights into regulation of complement activation.

Wiesmann, Christian; Katschke, Kenneth J; Yin, JianPing; Helmy, Karim Y; Steffek, Micah; Fairbrother, Wayne J; McCallum, Scott A; Embuscado, Lizette; DeForge, Laura; Hass, Philip E; van Lookeren Campagne, Menno.

Nature ; 444(7116): 217-20, 2006 Nov 09.

Artigo em Inglês | MEDLINE | ID: mdl-17051150

19.

Ribosomal Synthesis of Macrocyclic Peptides with Linear Î³⁴- and ß-Hydroxy-Î³⁴-amino Acids.

Adaligil, Emel; Song, Aimin; Cunningham, Christian N; Fairbrother, Wayne J.

ACS Chem Biol ; 16(8): 1325-1331, 2021 08 20.

Artigo em Inglês | MEDLINE | ID: mdl-34270222

20.

Ribosomal Synthesis of Macrocyclic Peptides with ß²- and ß^2,3-Homo-Amino Acids for the Development of Natural Product-Like Combinatorial Libraries.

Adaligil, Emel; Song, Aimin; Hallenbeck, Kenneth K; Cunningham, Christian N; Fairbrother, Wayne J.

ACS Chem Biol ; 16(6): 1011-1018, 2021 06 18.

Artigo em Inglês | MEDLINE | ID: mdl-34008946

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