Detalhe da pesquisa
1.
Enantioselective Synthesis of 3,3-Difluoropyrrolidin-4-ol, a Valuable Building Block in Medicinal Chemistry.
J Org Chem
; 81(10): 4359-63, 2016 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27138111
2.
Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.
Sci Rep
; 8(1): 15458, 2018 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30337562
3.
Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
J Med Chem
; 60(23): 9599-9616, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29072452
4.
A novel CDK9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor models.
Mol Cancer Ther
; 13(6): 1442-56, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24688048