1.
Biochem Biophys Res Commun
; 500(3): 676-681, 2018 06 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29678583
RESUMO
FAM122A is a highly conserved protein in mammals. Here, we identify that FAM122A can be sumoylated at lysine 89, which can be de-conjugated by SENP1. Furthermore, the sumoylation of FAM122A reduces the PP2A-Cα protein level together with the reduced phosphatase activity of PP2A, which suppresses cell proliferation. Collectively, our results suggest that the sumoylation of FAM122A may have a significant role in cellular function.