Detalhe da pesquisa
1.
Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility.
Mol Psychiatry
; 27(8): 3272-3285, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35505090
2.
An epigenetic blockade of cognitive functions in the neurodegenerating brain.
Nature
; 483(7388): 222-6, 2012 Feb 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22388814
3.
Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.
Bioorg Med Chem Lett
; 26(4): 1265-1271, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26804233
4.
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
Bioorg Med Chem
; 24(18): 4008-4015, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27377864
5.
Regulation of primitive hematopoiesis by class I histone deacetylases.
Dev Dyn
; 242(2): 108-21, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23184530
6.
Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.
Sci Rep
; 14(1): 9064, 2024 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38643236
7.
High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy.
Sci Rep
; 11(1): 17029, 2021 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34426604
8.
An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.
J Am Chem Soc
; 132(47): 16962-76, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21067169
9.
Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice.
Elife
; 92020 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32990597
10.
Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression.
ACS Chem Neurosci
; 10(8): 3769-3777, 2019 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31330099
11.
Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV.
Neuron
; 34(2): 235-44, 2002 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-11970865
12.
Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory.
ACS Chem Neurosci
; 9(9): 2262-2273, 2018 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29932631
13.
Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening.
Curr Protoc Hum Genet
; 92: 21.8.1-21.8.21, 2017 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28075486
14.
WNT/ß-Catenin Pathway and Epigenetic Mechanisms Regulate the Pitt-Hopkins Syndrome and Schizophrenia Risk Gene TCF4.
Mol Neuropsychiatry
; 3(1): 53-71, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28879201
15.
Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles.
J Biomol Screen
; 19(5): 738-48, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24710340
16.
A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests.
PLoS One
; 8(8): e71323, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23967191
17.
Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.
Neuropharmacology
; 64: 81-96, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22771460
18.
The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells.
Cancer Biol Ther
; 12(6): 484-93, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21738006
19.
Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease.
Neuropsychopharmacology
; 35(4): 870-80, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20010553
20.
Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.
ACS Med Chem Lett
; 2(1): 39-42, 2010 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21874153