Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Mechanically Ventilated Patients Shed High-Titer Live Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) for Extended Periods From Both the Upper and Lower Respiratory Tract.

Saud, Zack; Ponsford, Mark; Bentley, Kirsten; Cole, Jade M; Pandey, Manish; Jolles, Stephen; Fegan, Chris; Humphreys, Ian; Wise, Matt P; Stanton, Richard.

Clin Infect Dis ; 75(1): e82-e88, 2022 08 24.

Artigo em Inglês | MEDLINE | ID: mdl-35231086

2.

Increased frequency of CD4⁺ PD-1⁺ HLA-DR⁺ T cells is associated with disease progression in CLL.

Elston, Lauren; Fegan, Chris; Hills, Robert; Hashimdeen, Shaikh S; Walsby, Elisabeth; Henley, Peter; Pepper, Chris; Man, Stephen.

Br J Haematol ; 188(6): 872-880, 2020 03.

Artigo em Inglês | MEDLINE | ID: mdl-31702049

3.

Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration.

Pasikowska, Marta; Walsby, Elisabeth; Apollonio, Benedetta; Cuthill, Kirsty; Phillips, Elizabeth; Coulter, Eve; Longhi, Maria Serena; Ma, Yun; Yallop, Deborah; Barber, Linda D; Patten, Piers; Fegan, Chris; Ramsay, Alan G; Pepper, Chris; Devereux, Stephen; Buggins, Andrea G S.

Blood ; 128(4): 563-73, 2016 07 28.

Artigo em Inglês | MEDLINE | ID: mdl-27252234

4.

Telomere length is a critical determinant for survival in multiple myeloma.

Hyatt, Sam; Jones, Rhiannon E; Heppel, Nicole H; Grimstead, Julia W; Fegan, Chris; Jackson, Graham H; Hills, Robert; Allan, James M; Pratt, Guy; Pepper, Chris; Baird, Duncan M.

Br J Haematol ; 178(1): 94-98, 2017 07.

Artigo em Inglês | MEDLINE | ID: mdl-28342200

5.

Telomere length is an independent prognostic marker in MDS but not in de novo AML.

Williams, Jenna; Heppel, Nicole H; Britt-Compton, Bethan; Grimstead, Julia W; Jones, Rhiannon E; Tauro, Sudhir; Bowen, David T; Knapper, Steven; Groves, Michael; Hills, Robert K; Pepper, Chris; Baird, Duncan M; Fegan, Chris.

Br J Haematol ; 178(2): 240-249, 2017 07.

Artigo em Inglês | MEDLINE | ID: mdl-28486748

6.

Development and characterization of a physiologically relevant model of lymphocyte migration in chronic lymphocytic leukemia.

Walsby, Elisabeth; Buggins, Andrea; Devereux, Stephen; Jones, Ceri; Pratt, Guy; Brennan, Paul; Fegan, Chris; Pepper, Chris.

Blood ; 123(23): 3607-17, 2014 Jun 05.

Artigo em Inglês | MEDLINE | ID: mdl-24637360

7.

CD8⁺ T-cell recognition of a synthetic epitope formed by t-butyl modification.

Reid, Reiss A; Redman, James E; Rizkallah, Pierre; Fegan, Chris; Pepper, Chris; Man, Stephen.

Immunology ; 2014 Oct 05.

Artigo em Inglês | MEDLINE | ID: mdl-25284607

8.

Is venetoclax a new wonder drug in CLL?

Fegan, Chris; Pepper, Chris.

Br J Haematol ; 185(4): 643-646, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30859555

9.

Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease.

Lin, Thet Thet; Norris, Kevin; Heppel, Nicole H; Pratt, Guy; Allan, James M; Allsup, David J; Bailey, James; Cawkwell, Lynn; Hills, Robert; Grimstead, Julia W; Jones, Rhiannon E; Britt-Compton, Bethan; Fegan, Chris; Baird, Duncan M; Pepper, Chris.

Br J Haematol ; 167(2): 214-23, 2014 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-24990087

10.

A multi-centre phase I trial of the PARP inhibitor olaparib in patients with relapsed chronic lymphocytic leukaemia, T-prolymphocytic leukaemia or mantle cell lymphoma.

Pratt, Guy; Yap, Christina; Oldreive, Ceri; Slade, Daniel; Bishop, Rebecca; Griffiths, Mike; Dyer, Martin J S; Fegan, Chris; Oscier, David; Pettitt, Andrew; Matutes, Estella; Devereux, Stephen; Allsup, David; Bloor, Adrian; Hillmen, Peter; Follows, George; Rule, Simon; Moss, Paul; Stankovic, Tatjana.

Br J Haematol ; 182(3): 429-433, 2018 08.

Artigo em Inglês | MEDLINE | ID: mdl-28643365

11.

CLL: a supplementary question?

Pepper, Chris; Fegan, Chris.

Blood ; 117(5): 1439-40, 2011 Feb 03.

Artigo em Inglês | MEDLINE | ID: mdl-21292782

12.

Blinatumomab induces autologous T-cell killing of chronic lymphocytic leukemia cells.

Wong, Ryan; Pepper, Chris; Brennan, Paul; Nagorsen, Dirk; Man, Stephen; Fegan, Chris.

Haematologica ; 98(12): 1930-8, 2013 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-23812940

13.

Apoptosis deregulation in CLL.

Fegan, Chris; Pepper, Chris.

Adv Exp Med Biol ; 792: 151-71, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-24014296

14.

Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cells.

Hamilton, Emma; Pearce, Laurence; Morgan, Liam; Robinson, Sophie; Ware, Vicki; Brennan, Paul; Thomas, N Shaun B; Yallop, Deborah; Devereux, Stephen; Fegan, Chris; Buggins, Andrea G S; Pepper, Chris.

Br J Haematol ; 158(5): 589-99, 2012 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-22712573

15.

Defining the prognosis of early stage chronic lymphocytic leukaemia patients.

Pepper, Chris; Majid, Aneela; Lin, Thet Thet; Hewamana, Saman; Pratt, Guy; Walewska, Renata; Gesk, Stefan; Siebert, Reiner; Wagner, Simon; Kennedy, Ben; Miall, Fiona; Davis, Zadie A; Tracy, Ian; Gardiner, Anne C; Brennan, Paul; Hills, Robert K; Dyer, Martin J S; Oscier, David; Fegan, Chris.

Br J Haematol ; 156(4): 499-507, 2012 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-22171799

16.

The number of cytomegalovirus-specific CD4+ T cells is markedly expanded in patients with B-cell chronic lymphocytic leukemia and determines the total CD4+ T-cell repertoire.

Pourgheysari, Batoul; Bruton, Rachel; Parry, Helen; Billingham, Lucinda; Fegan, Chris; Murray, Jim; Moss, Paul.

Blood ; 116(16): 2968-74, 2010 Oct 21.

Artigo em Inglês | MEDLINE | ID: mdl-20562332

17.

Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis.

Lin, Thet Thet; Letsolo, Boitelo T; Jones, Rhiannon E; Rowson, Jan; Pratt, Guy; Hewamana, Saman; Fegan, Chris; Pepper, Chris; Baird, Duncan M.

Blood ; 116(11): 1899-907, 2010 Sep 16.

Artigo em Inglês | MEDLINE | ID: mdl-20538793

18.

Understanding cancer cell survival is key to patient survival.

Fegan, Chris; Pepper, Chris.

Lancet Oncol ; 16(2): 122-4, 2015 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-25638674

19.

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers.

Pepper, Chris; Lin, Thet Thet; Pratt, Guy; Hewamana, Saman; Brennan, Paul; Hiller, Louise; Hills, Robert; Ward, Rachel; Starczynski, Jane; Austen, Belinda; Hooper, Laura; Stankovic, Tatjana; Fegan, Chris.

Blood ; 112(9): 3807-17, 2008 Nov 01.

Artigo em Inglês | MEDLINE | ID: mdl-18599795

20.

The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target.

Hewamana, Saman; Alghazal, Suhair; Lin, Thet Thet; Clement, Matthew; Jenkins, Chris; Guzman, Monica L; Jordan, Craig T; Neelakantan, Sundar; Crooks, Peter A; Burnett, Alan K; Pratt, Guy; Fegan, Chris; Rowntree, Clare; Brennan, Paul; Pepper, Chris.

Blood ; 111(9): 4681-9, 2008 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-18227347

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Mechanically Ventilated Patients Shed High-Titer Live Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) for Extended Periods From Both the Upper and Lower Respiratory Tract.

Increased frequency of CD4⁺ PD-1⁺ HLA-DR⁺ T cells is associated with disease progression in CLL.

Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration.

Telomere length is a critical determinant for survival in multiple myeloma.

Telomere length is an independent prognostic marker in MDS but not in de novo AML.

Development and characterization of a physiologically relevant model of lymphocyte migration in chronic lymphocytic leukemia.

CD8⁺ T-cell recognition of a synthetic epitope formed by t-butyl modification.

Is venetoclax a new wonder drug in CLL?

Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease.

A multi-centre phase I trial of the PARP inhibitor olaparib in patients with relapsed chronic lymphocytic leukaemia, T-prolymphocytic leukaemia or mantle cell lymphoma.

CLL: a supplementary question?

Blinatumomab induces autologous T-cell killing of chronic lymphocytic leukemia cells.

Apoptosis deregulation in CLL.

Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cells.

Defining the prognosis of early stage chronic lymphocytic leukaemia patients.

The number of cytomegalovirus-specific CD4+ T cells is markedly expanded in patients with B-cell chronic lymphocytic leukemia and determines the total CD4+ T-cell repertoire.

Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis.

Understanding cancer cell survival is key to patient survival.

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers.

The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target.