Detalhe da pesquisa
1.
Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo.
Nature
; 578(7793): 160-165, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31969707
2.
Differential recognition of HIV-stimulated IL-1ß and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages.
PLoS Pathog
; 17(4): e1009417, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33861800
3.
Synthesis and evaluation of 2-phenyl-1,4-butanediamine-based CCR5 antagonists for the treatment of HIV-1.
Bioorg Med Chem Lett
; 21(5): 1394-8, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21292480
4.
The relative activity of "function sparing" HIV-1 entry inhibitors on viral entry and CCR5 internalization: is allosteric functional selectivity a valuable therapeutic property?
Mol Pharmacol
; 75(3): 490-501, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19064629
5.
Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor.
J Med Chem
; 49(2): 727-39, 2006 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-16420058
6.
Development of a novel high-throughput surrogate assay to measure HIV envelope/CCR5/CD4-mediated viral/cell fusion using BacMam baculovirus technology.
J Biomol Screen
; 8(4): 463-70, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-14567799
7.
Biological and Structural Characterization of Rotamers of C-C Chemokine Receptor Type 5 (CCR5) Inhibitor GSK214096.
ACS Med Chem Lett
; 5(12): 1296-9, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25516787
8.
Rational design of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.
J Med Chem
; 55(23): 10601-9, 2012 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23137340
9.
Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.
J Med Chem
; 51(16): 5000-8, 2008 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18665583
10.
The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral.
Antimicrob Agents Chemother
; 52(3): 901-8, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18160521
11.
Anti-human immunodeficiency virus type 1 activity of the nonnucleoside reverse transcriptase inhibitor GW678248 in combination with other antiretrovirals against clinical isolate viruses and in vitro selection for resistance.
Antimicrob Agents Chemother
; 49(11): 4465-73, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16251284
12.
Antiviral activity of GW678248, a novel benzophenone nonnucleoside reverse transcriptase inhibitor.
Antimicrob Agents Chemother
; 49(10): 4046-51, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16189079
13.
Mechanism of action of the ribopyranoside benzimidazole GW275175X against human cytomegalovirus.
Antimicrob Agents Chemother
; 48(5): 1647-51, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15105116