GISSI trial: early results and late follow-up. Gruppo Italiano per la Sperimentazione della Streptochinasi nell'Infarto Miocardico.

In the GISSI trial, 11,712 patients with acute myocardial infarction were randomized to receive either standard care or standard care with 1.5 million units streptokinase intravenously. A highly significant reduction in mortality during hospitalization in streptokinase-treated patients was observed. The mortality at 1 year was determined in 98.3% of the patients who had been originally randomized; the 1 year mortality of patients discharged alive was similar in those patients treated with streptokinase and those who were not; that is, the beneficial effects of streptokinase treatment on survival that were observed in the hospital phase of the study persisted unchanged and with comparable statistical significance for 1 year. However, a higher incidence of reinfarction occurred in the treated versus the control groups both during the hospital phase and at the 6 month follow-up. Streptokinase treatment had no detectable effect in patients with a history of previous infarction.

Transient myocardial ischemia during daily life in rest and exertional angina pectoris and comparison of effectiveness of metoprolol versus nifedipine.

The clinical characteristics of 65 patients with mixed angina were classified by means of (1) a questionnaire investigating the proportion of symptoms occurring at rest and on effort, (2) an exercise stress test, (3) 24-hour ambulatory Holter monitoring, and (4) coronary arteriography. According to the questionnaire, the proportion of effort-induced anginal episodes ranged from 1 to 99%. The ischemic threshold during exercise testing ranged from 110 x 10(2) to 350 x 10(2) mm Hg x beats/min. At least 1 episode of ST-segment depression was observed in 29 of the 65 patients during Holter monitoring. Ischemic episodes during Holter monitoring were more frequent (p less than 0.05) in patients reporting greater than or equal to 50% of anginal attacks on effort, with moderate to severe limitation of exercise capacity and with multivessel coronary artery disease. The effect on ambulatory ischemia of a 6-week treatment with a beta blocker (metoprolol CR, 200 mg once daily) or a dihydropyridine calcium antagonist (nifedipine retard 20 mg twice daily) were then compared according to a double-blind, parallel group design. Metoprolol significantly reduced the number and duration of the ischemic episodes during daily life (p less than 0.05) irrespective of the patients' clinical characteristics. Nifedipine was ineffective, particularly in patients with angina predominantly on effort and with a moderate to severe reduction in exercise tolerance. It is concluded that in patients with mixed angina, ischemic episodes during daily life are more likely to occur in patients with a clinical presentation suggesting poor coronary reserve.(ABSTRACT TRUNCATED AT 250 WORDS)

Signal-averaged electrocardiography and Doppler echocardiographic study in predicting acute rejection in heart transplantation.

BACKGROUND AND METHODS: In a prospective protocol for noninvasive diagnosis of acute cardiac rejection, 83 routine endomyocardial biopsies, followed each time by the analysis of signal-averaged electrocardiography and by a cardiac Doppler echocardiographic study, were performed in 18 heart transplant recipients. The follow-up time was 5 +/- 3.6 months. To detect noninvasively acute cardiac rejection, we compared biopsy findings with the presence of late potentials at signal-averaged electrocardiography and with two diastolic indexes, pressure half-time, and isovolumic relaxation time obtained from Doppler echocardiographic study. RESULTS: Thirteen acute rejection crises requiring modification of immunosuppression were diagnosed by means of endomyocardial biopsy. This clinically relevant acute cardiac rejection was associated with the presence of late potentials in 69% of cases and with the presence of pressure half-time < or = 55 msec and isovolumic relaxation time < or = 60 msec in 69% and 62% of cases, respectively. Sensitivity and specificity were as follows: for late potentials, 69% and 71%; for pressure half-time < or = 55 msec, 69% and 76%; for isovolumic relaxation time < or = 60 msec, 62% and 83%, respectively. The presence in a single patient of at least one abnormal parameter showed a sensitivity of 100% and a specificity of 60% in detecting important rejection. CONCLUSIONS: These data support the use of combined signal-averaged electrocardiography and Doppler echocardiographic study of the left ventricular diastolic function in the screening of acute cardiac rejection. Such results can suggest when endomyocardial biopsy should be performed, with the reliance that a normal noninvasive study highly excludes the presence of acute cardiac rejection requiring intensified immunosuppression.

[Automatic clinical electrocardiography laboratory of the Udine regional hospital. Considerations on 50,000 tracings automatically analyzed with computers]. / Il laboratorio automatico di elettrocardiografia clinica dell'Ospedale Regionale di Udine. Considerazioni su 50,000 tracciati analizzati automaticamente mediante calcolatore

Automatic ECG processing has now passed beyond the experimental stage into the realm of clinical practice. It offers the most advanced solution to the organisation problems faced by ECG laboratories, particularly in large hospitals. A centralised laboratory for this work was first set up in Italy in 1973 at the Udine Regional Hospital. Its instrumentation and organisation are described and a consecutive sample of 1000 ECGs culled from the 50,000 computerised since its inception are discussed.

[Programmed rehabilitation of infarct patients. Methods and results]. / La riabilitazione programmata dell'infartuato. Metodi e risultati.

Rehabilitation is now regarded as an integral part of the treatment of myocardial infarctees. The programme followed by the cardiological institutions of the Udine regional hospital and physical medicine and rehabilitation is described. Divided into four stages, it is put into effect after careful assessment of the patient's physical capability and psychological profile. The results of three years' work are presented.

[Medico-social aspects of the post-infarct state. Clinical, functional, psychological and return-to-work studies of 100 patients with myocardial infarct treated in the coronary unit]. / Aspetti medico-sociali dello stato postinfartuale. Valutazione clinica, funzionale, psicologica e ritorno al lavoro di 100 infartuati trattati nell'unitá coronarica

To determine whether intensive care unit are able to improve long term as well as immediate prognosis of acute myocardial infarction, one hundred patients, aged 40 to 60 years, six months to three years after discharge have been studied. All patients were examined with ergometric test, psychological assessment and medico-social survey. Comparison was made with patients treated in general medical wards. Correlations between clinical picture, psychological pattern, functional capacity and return to work prove that treatment in a coronary care unit positively affects the future of these patients. The importance of a rehabilitation program and its principles are also discussed.

[Usefulness of multicenter evaluation of the reliability of a program for automatic analysis in clinical electrocardiography]. / Utilità della valutazione policentrica dell'affidabilità di un programma per l'analisi automatica in elettrocardiografia clinica.

The HP-5 program for computer analysis of the ECG has been evaluated as far as sensibility and specificity in a multicenter study. A consistent number of tracings were sampled according to a statistical formula and all measurements and statements given by the computer were checked in a standardized manner. The collected data were classified and computerized. The HP-5 program has shown a very high specificity for tracings classified as normal (0.7% of false negatives) and for those classified abnormal (no false positive), while the level of agreement between manual and computer readings of the tracings classified atypical or borderline, was fair (75%). It is concluded that the new program represents a significant step forward in the practical use of computerized ECG.

[Reintervention on valve prosthesis. 13 years' experience]. / Reintervento su protesi valvolare. Tredici anni di esperienza.

1584 valve prosthesis implants [1231 mechanical (MP) and 353 biological (BP)] were carried out personally between March 1974 and December 1986. Over the same period, 72 patients, 36 m and 26 f, average age 48, underwent 75 reintervention (RI) on 80 malfunctioning prostheses 41 MP, 39 BP, 41 in mitral position, 28 aortic, 1 tricuspid). The reasons for RI in the MP were: partial detachment (61%), infectious endocarditis (19.5%), mechanical dysfunction (14.7%), thrombosis (2.4%), wear (2.4%) and in the BP: wear (84.6%), infectious endocarditis (12.8%), partial detachment (2.6%). The malfunction was diagnosed before the onset of subjective symptomatology in 30.7% of patients. Operative mortality (OM) was 17.3% related to the functional class (II = 0%; III = 2.7%; IV = 38.7%) and to whether or not the intervention was an emergency or of choice (90.9% and 4.7% respectively). Mortality was higher in patients operated on for infectious endocarditis (38.4%) and in wearers of MP (28.2% vs. 5.7% BP); however this difference is largely attributable to a difference in NYHA class. It is concluded that reintervention on valvular prosthesis may have a very prognosis provided diagnosis of malfunction is quick enough to avoid excessive functional deterioration.

[Diagnostic value of Q wave changes during the exercise test. Review of the literature and personal experience]. / Il valore diagnostico delle modificazioni dell'onda Q durante test ergometrico. Revisione della letteratura ed esperienza personale.

UNLABELLED: To test if a low Q wave voltage and its faulty increase after exercise is an additional sign of myocardial ischemia, 64 pts with no previous myocardial infarction, bundle branch block or left ventricular hypertrophy were studied by a treadmill test and coronary angiography. Nineteen had single vessel disease (SVD), 21 double vessel disease (DVD), 4 triple vessel disease (TVD) and 20 normal coronary arteries. Sensitivity (SENS), specificity (SPEC) and predictive value (P) of Q wave changes have resulted as follows: 84%, 55%, 80.4%, respectively, compared to 79.5%, 75%, 87.5% of ST modifications associated or not with angina. The SENS of Q wave changes was 72% in SVD and 92% in multivessel disease (p less than 0.05). In 68% of our pts ST and Q wave changes gave concordant results and their combination increased SENS, SPEC, PV to 90.1%, 80%, 90.3%. IN CONCLUSION: Q wave analysis can provide further evidence of myocardial ischemia and can increase SENS, SPEC of stress test. In our experience Q wave is a more sensitive finding than ST depression in multivessel disease.

[Transesophageal and epicardial echocardiography in the evaluation of conservative surgery of the mitral valve. Complementary methods?]. / L'ecocardiografia transesofagea ed epicardica nella valutazione della chirurgia conservativa della valvola mitrale. Metodiche complementari?

BACKGROUND: Over the last two decades several new surgical methods for repairing a regurgitant mitral valve have been proposed. Unfortunately, early applications of such techniques were not always encouraging because the evaluation in the operating room led to false optimism due to a marked difference between static and functional anatomy of the repaired valve. By means of intraoperative echocardiography, be it transesophageal or epicardial, it is now possible to assess the functional result immediately after valvuloplasty and to decide about further surgery, right at the operating table. MATERIALS AND METHODS: Thirty-six patients (mean age 61.8 years) who underwent mitral valve repair were studied; all underwent preoperative transthoracic echocardiography in the week preceding surgery, and intraoperative transesophageal echo before cardiopulmonary bypass. The surgical results were evaluated by epicardial and/or transesophageal echocardiography in the operating room, and by transthoracic and/or transesophageal approach during follow-up. RESULTS: In 5 patients with intraoperative echocardiography done before valve repair, leaflets pathology and subvalvular apparatus were better evaluated. Besides, in 3 patients the more evident calcification of the leaflets led the surgeon to decide on direct replacement rather the reconstruction of the valve. The postoperative assessment has shown an unsatisfactory correction in 8 patients (24%). In 4 of these patients an important mitral regurgitation was reported and in 2 there was a moderate regurgitation. In the last 2, a iatrogenic stenosis had resulted. Of these 8 patients, 6 underwent valve replacement using an artificial valve. The other 2 patients (one with moderate stenosis and the other with moderate regurgitation) did not undergo a second operation because of the excessive operating time taken for valvuloplasty and the advanced age of the patients. During follow-up, from 6 to 54 months, a remarkable mitral regurgitation was present in 4 patients, one being severe and the other moderate. A persistence of ventricular dilatation was present only in these patients, while in the remainder the left ventricular diameters were normal. Finally, the mitral valve area after six months was between 1.5 an d4 cm2. CONCLUSIONS: Intraoperative echocardiography, both transesophageal and epicardial, can help the surgeon by giving him useful diagnostic information, if carried out before reconstructing the mitral valve with regurgitation. Its application is even more useful if applied straight after the surgical intervention. Unsatisfactory results may be evidenced at once and the operating team will decide right at the table for further repair or replacement, thus avoiding a second operation and the relevant risks.

[Permanent cardiac pacing in Italy to-day (author's transl)]. / L'elettrostimolazione cardiaca permanente in Italia, oggi.

The current status of cardiac pacing in Italy is outlined by the following figures: 121 hospitals implant over 10,000 pacemakers each year. Of this number 69% are new implants which raises the incidence of new treated cases to 111 per million population, with the highest peach (197) in Tuscany. This figure was only 61 in 1973. At elsewhere, the dominant age group is the 7th decade; the prime indication for pacing is the symptomatic patient with a-v block (62% of all cases), the next most common one being chronic fascicular block (11%) and sick sinus syndrome (10%). The transvenous route is utilized in 98.3% of cases. The pacemaker of choice is the R-inhibited units; fixed rate units are used in only 4% of cases and units with conventional mercury battery cells in 66%, in favour of pacers with longer energy sources (e.g. lithium). Fifteen companies are supplying pacemakers in Italy and four of them are local manufacturers. An estimate 18,000 patients are being paced throughout the country to-day. Their density is highest in the region Friuli-Venezia Giulia (948 per million population). Follow-up of patients as a whole is not satisfactory being adequate only in about 50% of hospitals; telephone monitoring is available but in a few locations. The average cost of permanent pacing in Italy is the equivalent of 2.50 U.S. dollars per day.

[Health education as the principal element of prevention in cardiology: methods of intervention. Conclusions and operative suggestions]. / L'educazione sanitaria come momento cardine della prevenzione in cardiologia: modalità di intervento. Sintesi conclusiva e proposte operative.

In this symposium an extensive review of the basic role of health education for the prevention of cardiovascular diseases, has been made. Principles and methods have been analysed in the light of recent advances in primary and secondary prevention of rheumatic heart disease, ischemic heart disease and hypertension. The cardiologist's role in health education of individual subjects and of high-risk target groups or of the whole community, has been stressed. Recent trials have shown that it is possible to achieve behavioural changes and a reduction in the levels of risk factors in a good proportion of participants. It should be possible to bring up children virtually free from risk factors. Cardiologists on their own are unlikely to succeed in a program of prevention. They need the help of many others including public health workers, sociologists, nurses and above all, general practitioners. Cardiologists however have responsibility for leadership and for providing background knowledge. Cardiologists need to be educated and motivated. Health education should be founded on a scientific basis and should be organized in an efficient and planned fashion. Medical and post-graduated schools, hospital institutions and cardiological associations must be specifically involved in preparing the cardiologists for this specific task. On the other hand, dedicated teams or sections in the cardiological departments must be activated to promote, coordinate and carry out specific programs of health education for preventing cardiovascular diseases. The attention of governmental authorities should be drawn to the theoretical and practical importance of health education in preventive cardiology, especially in connection with the planning, organization and direction of health education at the regional and national level.