Detalhe da pesquisa
1.
Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats.
Toxicol Pathol
; 49(6): 1174-1192, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34060347
2.
Assessment of Preclinical Liver and Skeletal Muscle Biomarkers Following Clofibrate Administration in Wistar Rats.
Toxicol Pathol
; 45(4): 506-525, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28485676
3.
Vehicle Systems and Excipients Used in Minipig Drug Development Studies.
Toxicol Pathol
; 44(3): 367-72, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26674803
4.
Genotoxicity testing of peptides: folate deprivation as a marker of exaggerated pharmacology.
Toxicol Appl Pharmacol
; 279(3): 419-427, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24997324
5.
Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human clinical trials.
Regul Toxicol Pharmacol
; 70(1): 413-29, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25078890
6.
A global pharmaceutical company initiative: an evidence-based approach to define the upper limit of body weight loss in short term toxicity studies.
Regul Toxicol Pharmacol
; 67(1): 27-38, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23602904
7.
Pediatric Safety of Polysorbates in Drug Formulations.
Children (Basel)
; 7(1)2019 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31877624
8.
Interspecies Variation of Outer Retina and Choriocapillaris Imaged With Optical Coherence Tomography.
Invest Ophthalmol Vis Sci
; 60(10): 3332-3342, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31370061
9.
An in vitro embryotoxicity assay based on the disturbance of the differentiation of murine embryonic stem cells into endothelial cells. II. Testing of compounds.
Toxicol In Vitro
; 21(8): 1631-40, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17719739
10.
An in vitro embryotoxicity assay based on the disturbance of the differentiation of murine embryonic stem cells into endothelial cells. I: Establishment of the differentiation protocol.
Toxicol In Vitro
; 21(8): 1619-30, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17723288
11.
From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides.
Toxicol Sci
; 157(1): 112-128, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28123102
12.
Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling.
Mol Ther Nucleic Acids
; 6: 89-105, 2017 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28325303
13.
Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy.
Mol Oncol
; 10(8): 1317-29, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27507537
14.
Assessment of the genotoxic potential of azidothymidine in the comet, micronucleus, and Pig-a assay.
Toxicol Sci
; 135(2): 309-16, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23811826
15.
Morphologic and functional effects of gamma secretase inhibition on splenic marginal zone B cells.
Int J Alzheimers Dis
; 2012: 289412, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23316412
16.
A European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development.
Regul Toxicol Pharmacol
; 50(3): 345-52, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18295384