Detalhe da pesquisa
1.
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.
Bioorg Med Chem Lett
; 22(16): 5317-21, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22796182
2.
Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase.
Bioorg Med Chem Lett
; 21(9): 2776-9, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20880703
3.
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants.
Bioorg Med Chem Lett
; 21(13): 3935-8, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21636271
4.
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils.
Org Biomol Chem
; 9(14): 5137-48, 2011 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21629961
5.
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
J Med Chem
; 51(11): 3154-70, 2008 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18479118
6.
Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies.
J Med Chem
; 51(5): 1278-94, 2008 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18278860
7.
An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds.
J Org Chem
; 73(21): 8458-68, 2008 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-18844418
8.
Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity.
Bioorg Med Chem Lett
; 18(19): 5213-6, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18786825
9.
Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target.
J Med Chem
; 48(13): 4367-77, 2005 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15974589
10.
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.
J Med Chem
; 48(23): 7153-65, 2005 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-16279773
11.
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.
J Med Chem
; 48(6): 1705-8, 2005 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15771414
12.
Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases.
Curr Pharm Des
; 9(8): 599-625, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12570795
13.
Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR).
J Med Chem
; 45(19): 4276-81, 2002 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-12213069
14.
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.
J Med Chem
; 55(23): 10387-404, 2012 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23145816
15.
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.
J Med Chem
; 54(5): 1401-20, 2011 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21319802
16.
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.
J Med Chem
; 53(12): 4803-7, 2010 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-20481570
17.
Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.
J Med Chem
; 52(21): 6946-50, 2009 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19831400
18.
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.
J Med Chem
; 52(11): 3548-62, 2009 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-19425598
19.
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.
J Med Chem
; 52(1): 151-69, 2009 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19072656
20.
Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials.
J Med Chem
; 52(2): 502-13, 2009 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19113955